Research / Equipment
研究と設備
研究者紹介
共同利用機器室
青山 浩准教授
分子の立体構造を知ることは、あらゆる自然科学研究における最重要かつ不可欠な基本工程です。また疾病に関係する標的分子の立体構造から医薬品を合理的に設計することが可能となります。そこで、Ｘ線結晶解析法とクライオ電子顕微鏡法を駆使して立体構造解析を行っています。
また、薬学研究科の共通機器の円滑な運営を計るとともに、大阪大学リノベーションセンターと協力して、全学の共通機器の運営にも参画しています。
研究テーマ
立体構造解析に基づく生体高分子の機能解明と薬学領域への展開
有機化合物から膜タンパク質複合体までの多様な分子の立体構造をX線結晶構造解析により解明することで、生命現象の理解と創薬展開を目指しています。
代表的な業績
Could London Dispersion Force Control Regioselective (2+2) Cyclodimerizations of Benzynes?
Takashi Ikawa, Yuta Yamamoto, Akito Heguri, Yutaka Fukumoto, Tomonari Murakami, Akira Takagi, Yuto Masuda, Kenzo Yahata, Hiroshi Aoyama, Yasuteru Shigeta, Hiroaki Tokiwa, Shuji Akai
J. Am. Chem. Soc., (2021) 143, 10853-10859
Crystallographic Structure of Novel Types of AgI-Mediated Base Pairs in Non-canonical DNA Duplex Containing 2′-O,4′-C-Methylene Bridged Nucleic Acids
Osamu Nakagawa*, Hiroshi Aoyama*, Akane Fujii, Yuki Kishimoto and Satoshi Obika
Chem. Eur J. (2021) 27, 3842-3848
The amino terminal domain plays an important role in transjunctional voltagedependent gating kinetics of Cx45 gap junctions
Artur Santos-Miranda, Honghong Chen, Robert C. Chen, Mamiko Odoko-Ishimoto, Hiroshi Aoyama and Donglin Bai
J.Mol.Cell.Cardiol. (2020) 143, 71-84
Monomeric Structure of an Active Form of Bovine Cytochrome c Oxidase
Kyoko Shinzawa-Itoh, Takashi Sugimura, Tomonori Misaki, Yoshiki Tadehara, Shogo Yamamoto, Makoto Hanada, Naomine Yano, Tetsuya Nakagawa, Shigefumi Uene, Takara Yamada, Hiroshi Aoyama, Eiki Yamashita, Tomitake Tsukihara, Shinya Yoshikawa, Kazumasa Muramoto
Proc. Natl. Acad. Sci. USA (2019), 116(40), 19945-19951
Hybridization and mismatch discrimination abilities of 2′,4′-bridged nucleic acids bearing 2-thiothymine or 2-selenothymine nucleobase
Takaki Habuchi, Takao Yamaguchi, Hiroshi Aoyama, Masahiko Horiba, Kosuke Ito and Satoshi Obika
J. Org. Chem. (2019), 84(3), 1430-1439
Total Synthesis of (-)-Agelastatin A: An SH2’ Radical Azidation Strategy
Izuru Tsuchimochi, Yuta Kitamura, Hiroshi Aoyama, Shuji Akai, Keiyo Nakai and Takehiko Yoshimitsu
Chem. Commun. (2018), 54(71), 9893-9896
Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure
Yasunori Mitsuoka, Hiroshi Aoyama, Akira Kugimiya, Yuko Fujimura, Tsuyoshi Yamamoto, Reiko Waki, Fumito Wada, Saori Tahara, Motoki Sawamura, Mio Noda, Yoshiyuki Hari and Satoshi Obika
Org. Biomol. Chem. (2016), 14(27), 6531-6538
Higd1a is a positive regulator of Cytochrome c Oxidase
Takaharu Hayashi, Yoshihiro Asano, Yasunori Shintani, Hiroshi Aoyama, Hidetaka Kioka, Osamu Tsukamoto, Masahide Hikita, Kyoko Shinzawa-Itoh, Kazuaki Takafuji, Shuichiro Higo, Hisakazu Kato, Satoru Yamazaki, Ken Matsuoka, Atsushi Nakano, Hiroshi Asanuma, Masanori Asakura, Tetsuo Minamino, Yu-ichi Goto, Takashi Ogura, Masafumi Kitakaze, Issei Komuro, Yasushi Sakata, Tomitake Tsukihara, Shinya Yoshikawa and Seiji Takashima
Proc. Natl. Acad. Sci. USA (2015), 112(5), 1553-1558
A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump
Hiroshi Aoyama, Kazumasa Muramoto, Kyoko Shinzawa-Itoh, Kunio Hirata, Eiki Yamashita, Tomitake Tsukihara, Takashi Ogura and Shinya Yoshikawa
Proc. Natl. Acad. Sci. USA (2009), 106(7), 2165-2169
Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase
Kyoko Shinzawa-Itoh*, Hiroshi Aoyama*, Kazumasa Muramoto, Hirohito Terada, Tsuyoshi Kurauchi, Yoshiki Tadehara, Akiko Yamasaki, Takashi Sugimura, Sadamu Kurono, Kazuo Tsujimoto, Tsunehiro Mizushima, Eiki Yamashita, Tomitake Tsukihara and Shinya Yoshikawa
EMBO J. (2007), 26, 1713-1725
