大阪大学大学院薬学研究科薬学部

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附属創薬センター
創薬臨床研究推進ユニット
構造展開ユニット

林邦忠特任准教授(常勤)

◆低分子化合物のハイスループットスクリーニング（HTS）
◆In vitro薬物動態(ADME)評価
◆In vivo薬物動態(PK)評価
◆In vitro心毒性予測
上記の創薬研究支援を行っています。

代表的な業績

Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV-Latency-Reversing Agents
Chemistry (Weinheim an der Bergstrasse, Germany) e202300677 2023年5月22日

URL:https://doi.org/10.1002/chem.202300677

Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment
Bioorganic & medicinal chemistry letters 129333-129333 2023年5月17日

URL:https://doi.org/10.1016/j.bmcl.2023.129333

Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
Science immunology 8(81) eadc9324 2023年3月

URL:https://www.science.org/doi/10.1126/sciimmunol.adc9324

Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues
ACS Medicinal Chemistry Letters 2022年8月

URL:https://pubs.acs.org/doi/10.1021/acsmedchemlett.2c00228

Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors
ACS Medicinal Chemistry Letters 13(7) 1077-1082 2022年6月

URL:https://pubs.acs.org/doi/10.1021/acsmedchemlett.2c00081

Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist
European Journal of Medicinal Chemistry 231 114160-114160 2022年3月

URL:https://pubmed.ncbi.nlm.nih.gov/35124531/

A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Nature Communications 12(1) 2021年12月

URL:https://www.nature.com/articles/s41467-021-24644-1

Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line
Journal of biological chemistry 293(26) 10333-10343 2018年6月

URL:https://doi.org/10.1074/jbc.RA118.002077

Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells
Journal of cell biology 215(1) 121-138 2016年10月

URL:https://pubmed.ncbi.nlm.nih.gov/27697926/

Zebu Cattle Are an Exclusive Legacy of the South Asia Neolithic
Molecular Biology and Evolution 27(1) 1-6 2010年1月1日

URL:https://doi.org/10.1093/molbev/msp213

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