Graduate School and School of Pharmaceutical Sciences, Osaka University

Research

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Faculty Members

Biopharmaceutics（Medical and Health Sciences）

Nakagawa ShinsakuProfessor

Ph.D. (Pharmacy)
Specialty: Biopharmaceutics, DDS
Vice President of Japan Society of Drug Delivery System, Vice President of Japanese Cosmetics Science Society
1988-1993 : Research Associate in Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
1993-1994 : Research Associate in Faculty of Pharmaceutical Sciences, Osaka University
1994-1999 : Assistant Professor in Faculty of Pharmaceutical Sciences, Osaka University
1999-2005 : Associate Professor in Graduate School of Pharmaceutical Sciences, Osaka University
2005- : Professor in Graduate School of Pharmaceutical Sciences, Osaka University

Research theme

Safety and effectiveness evaluation of tea catechins as functional food materials

Tea catechins show strong antioxidant activity, and have antiallergic action, antiviral action, brain function improving action and the like. We are conducting research to clarify the mechanism of action and to ensure the safety and effectiveness of functional food materials.

Improvement of absorption of poorly water-soluble compounds by DDS technology and evaluation of safety and efficacy

We are conducting DDS research to improve solubility by amorphizing poorly soluble compounds and to ensure safety and efficacy through pharmacokinetic analysis including absorption characteristics.

Representative achievements

Ishimoto K. et. al., Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion. J Food Sci Technol, in press.

URL:https://pubmed.ncbi.nlm.nih.gov/35068557/

Yamazawa T. et al., A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Nat Commun12(1):4293, 2021.

URL:https://www.nature.com/articles/s41467-021-24644-1

Ishimoto K. et al., Tea crude extracts effectively inactivate severe acute respiratory syndrome coronavirus 2. Lett Appl Microbiol, 74(1):2, 2021.

URL:https://sfamjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/lam.13591

Kitakami R. et al., Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg Med Chem 44:116292, 2021.

URL:https://pubmed.ncbi.nlm.nih.gov/34225167/

Matsuo T. et al., Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence. Life (Basel) 11(6):591, 2021.

URL:https://pubmed.ncbi.nlm.nih.gov/34205684/

Sakamoto K. et al., Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 12:751587, 2021

URL:https://pubmed.ncbi.nlm.nih.gov/34819858/

Otani S. et al.,Improved bioavailability of β-carotene by amorphous solid dispersion technology in rats. J Nutr Sci Vitaminol, 66: 207, 2020.

URL:https://pubmed.ncbi.nlm.nih.gov/32350183/

Yokoyama R. et al., (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. Pharmacol Biochem Behav, 191:172876, 2020.

URL:https://pubmed.ncbi.nlm.nih.gov/32088360/

Takeuchi S. et al., Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism. Front Neurosci. 14:521, 2020.

URL:https://pubmed.ncbi.nlm.nih.gov/32581681/

Ago Y., et al., (R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism. Int J Neuropsychopharmacol. 22(10):665, 2019

URL:https://pubmed.ncbi.nlm.nih.gov/31325908/

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