Graduate School and School of Pharmaceutical Sciences, Osaka University

Research

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Faculty Members

Drug Innovation Center Lead Exploration Unit

Lin BanghongSpecially Appointed Assosiate Professor

◆High-throughput screening of small molecule compounds
◆In vitro pharmacokinetic (ADME) evaluation
◆In vivo pharmacokinetic (PK) evaluation
◆In vitro cardiotoxicity prediction
We support the above drug discovery research.

Representative achievements

Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV-Latency-Reversing Agents
Chemistry (Weinheim an der Bergstrasse, Germany) e202300677

URL:https://doi.org/10.1002/chem.202300677

Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment
Bioorganic & medicinal chemistry letters 129333-129333

URL:https://doi.org/10.1016/j.bmcl.2023.129333

Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
Science immunology 8(81) eadc9324

URL:https://www.science.org/doi/10.1126/sciimmunol.adc9324

Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues
ACS Medicinal Chemistry Letters

URL:https://pubs.acs.org/doi/10.1021/acsmedchemlett.2c00228

Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors
ACS Medicinal Chemistry Letters 13(7) 1077-1082

URL:https://pubs.acs.org/doi/10.1021/acsmedchemlett.2c00081

Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist
European Journal of Medicinal Chemistry 231 114160-114160

URL:https://pubmed.ncbi.nlm.nih.gov/35124531/

A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Nature Communications 12(1)

URL:https://www.nature.com/articles/s41467-021-24644-1

Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line
Journal of biological chemistry 293(26) 10333-10343

URL:https://doi.org/10.1074/jbc.RA118.002077

Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells
Journal of cell biology 215(1) 121-138

URL:https://pubmed.ncbi.nlm.nih.gov/27697926/

Zebu Cattle Are an Exclusive Legacy of the South Asia Neolithic
Molecular Biology and Evolution 27(1) 1-6

URL:https://doi.org/10.1093/molbev/msp213

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