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Drug Innovation Center Lead Exploration Unit

Ishichi YujiSpecially Appointed Assosiate Professor

1991 Department of Chemistry, Faculty of Science, Osaka City University
1993 Department of Chemistry, Graduate School of Science, Osaka City University
2015 Ph.D (Pharmacy, Nagoya City University)
 “Medicinal Chemistry Research for Neurotransmitter Modulator”
[Work Experience]
1993 Takeda Pharmaceutical Company Ltd. Pharmaceutical Research Division
2017 Axcelead Drug Discovery Partners, Ltd.
2022 Lead Exploration Units, Graduate School of Pharmaceutical Science, Osaka University
2004 Poster Award Medicinal Chemistry Symposium 2004

Research theme

Drug discovery support based on academic seeds

In order to develop academia seeds into drug candidates, following supports using the knowledge and technology cultivated at pharmaceutical companies are provided:
1. Investigate the latest information on drug discovery targets and provide advice and proposals.
2. Evaluate hit compounds from the perspective of medicinal chemistry and ADME-T, and optimize their structures for drug candidates.
3. Provide advice and proposals for joint research and out-licensing with pharmaceutical companies.

Representative achievements

Novel Triple Reuptake Inhibitors with Low Risk of CAD Associated Liabilities: Design, Synthesis and Biological Activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and Related Compounds.
Ishichi, Y.; Kimura, E.; Honda, E.; Yoshikawa, M.; Nakahata, T.; Terao, Y.; Suzuki, A.; Kawai, T.; Arakawa, Y.; Ohta, H.; Kanzaki, N.; Nakagawa, H.; Terauchi, J.
Bioorg. Med. Chem., 2013, 21(15), 4600–4613.

Novel Acetylcholinesterase Inhibitor as Increasing Agent on Rhythmic Bladder Contractions: SAR of 8-{3-[1-(3-Fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and Related Compounds.
Ishichi, Y.; Sasaki, M.; Setoh, M.; Tsukamoto, T.; Miwatashi, S.; Nagabukuro, H; Okanishi, S.; Imai, S.; Saikawa, R.; Doi, T.; Ishihara, Y.
Bioorg. Med. Chem., 2005, 13(6), 1901–1911.

Amide-based Atropisomers in Tachykinin NK1-receptor Antagonists: Synthesis and Antagonistic Activity of Axially Chiral N-benzylcarboxamide Derivatives of 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5] oxazocin-6-one.
Ishichi, Y.; Ikeura, Y.; Natsugari, H.
Tetrahedron, 2004, 60(20), 4481–4490.