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Molecular Neuropharmacology(Medical and Health Sciences)

Seiriki KaoruSpecially Appointed Assistant Professor

BA, Osaka University, Pharmaceutical Sciences (2013)
Ph.D, Osaka University, Graduate School of Pharmaceutical Sciences (2017)
Specially appointed Assistant Professor, Osaka University (2017-)

Research theme

Neural circuits in stress-related psychiatric disorders

Stress responses are the physiological reaction for environmental adaptation; however, severe stress can cause excessive and persistent fear and anxiety. To understand whether and how distinct or overlapping neuronal ensembles regulate different responses to physiological and severe stress, we are investigating neural circuit structures and functions by using viral-genetic labeling, mesoscopic imaging, chemo-/opto-genetics, and behavioral analysis.

Representative achievements

Baba M*, Yokoyama K*, Seiriki K*, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hayata-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. Neuropsychopharmacology. 44:2125-2135 (2019)

Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H. Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST. Nature Protocols, 14:1509-1529 (2019)

Seiriki K*, Kasai A*, Hashimoto T*, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H. High-speed imaging and scalable whole-brain imaging in rodents and primates. Neuron, 94:1085-1100 (2017)