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Faculty Members


Biochemistry and Molecular Biology(Biology)

Mizuguchi HiroyukiProfessor

1991-1996 Ph.D. in Pharmaceutical Science, Osaka University, Osaka, Japan.
1996-1997 Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
1997-1998 Department of Medical Genetics, University of Washington, Seattle, WA, USA.
1998-2005 National Institute of Health Sciences, Tokyo, Japan.
2005-2014 Project Leader / Chief Project Leader / Adjunct Project Leader, National Institute of Biomedical Innovation, Osaka, Japan.
2008-Present Professor, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
2014--Present Adjunct Project Leader, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.

Research theme

Development of gene transfer technology and application for gene therapy, regenerative medicine, vaccine, and virus therapy

Generation of functional hepatocytes and enterocytes by using regenerative medicine-derived techniques for pharmaceutical research and regenerative medicine

Development of genome editing technology and application for gene therapy and stem cell research

Functional analysis of non-coding RNA and application for life science research

Representative achievements

Yamashita T. et al., Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research. Mol. Ther. Methods. Clin. Dev., 22, 263-278 (2021)

Ichikawa M. et al., Vinblastine treatment enhances the intestinal functions and decreases the undifferentiated cell contamination of human iPS cell-derived intestinal epithelial-like cells. Mol. Ther. Methods. Clin. Dev., 20, 463-472 (2021) 

Shimizu K. et al., Adenovirus vector-induced IL-6 promotes leaky adenoviral gene expression, leading to acute hepatotoxicity. J. Immunol., 206, 410-421 (2021)

Takayama K. et al., Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system. Nuc. Acid Res., 45, 5198-5207 (2017)

Takayama K. et al., Prediction of inter-individual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes. Proc. Natl. Acad. Sci. USA., 111, 16772-16777 (2014)

Blumberg R. et al., Protective mucosal immunity mediated by epithelial CD1d and IL-10, Nature, 509, 497-502 (2014)

Yamaguchi T. et al., Induction of type I interferon by adenovirus-encoded small RNAs. Proc. Natl. Acad. Sci. USA., 107, 17286-17291 (2010)

Uno K. et al., Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science, 312, 1656-1659 (2006)

Kishimoto H. et al., In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus. Nat. Med., 12, 1213-1219 (2006)

Mizuguchi H. and Kay MA. Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method. Hum. Gene Ther., 9, 2577-2583 (1998)