Research
Faculty Members
Strucure and Function Analysis of Biomolecules（Chemistry）
Moriguchi MaikoSpecially Appointed Assistant Professor
Graduate School of Agricultural Science, Faculty of Agriculture,
Kobe University
Ph.D. in Agriculture (March 24, 2021)
Current position: Osaka University Graduate School of Pharmaceutical Sciences, Specially Appointed Researcher
Research theme
Development of a new grid for cryo-electron microscopy
Graphene oxide can be used as a support film for the TEM grid used in the cryo-electron microscope under development. In recent years, single particle analysis using a cryo-electron microscope has attracted a great deal of attention, but protein localization and orientation bias have become issues in the conventional analysis using a grid that supports a carbon film. We are working on the development of graphene oxide with added functionality by applying an oxygen functional group introduction method based on photoactivation into chlorine dioxide.
Representative achievements
Hassabelrasoul H., Moriguchi M., Kang B., Siribel A. A., Kuse M.
“Isolation and identification of metabolites from ethyl acetate leaf extract of Solenostemma argel”
Agriculture and Natural Resources, 2021, 55, 757-763.
Moriguchi M., Takahashi R., Kang B., Kuse M.
“Expression of recombinant apopholasin using a baculovirus–silkworm multigene expression system and activation via dehydrocoelenterazine,” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127177(1-5).
Kuse M., Moriguchi M., Hachida M., Takikawa H.
“Total Synthesis of (±)-Ramariolides C and D”
Chemistry Letters, 2017, 46, 1409−1411.
