In the process from development to aging of an individual, not only the control of DNA acquired modifications (epigenetics) but also the dynamic changes in RNA acquired modifications (epitranscriptomics) and the subsequent protein translation control mechanisms are thought to play an ingenious function. In this study, we will explore law of life by analyzing the spatio-temporal and comprehensive variation of RNA modifications and elucidating their functions.

Using primary cultured cells derived from postoperative clinical cancer specimens and tumors transplanted in mice, we will explore molecules involved in cancer development and malignant transformation. Furthermore, we will discover small molecule compounds that can control the functions of these molecules by making full use of AI, etc., and develop innovative therapeutic drugs for cancer.

The ALKBH family molecules are human proteins with domains similar to the E. coli protein AlkB. We were the first in the world to identify the ALKBH family molecules and also found that they are highly expressed in cancer. Furthermore, we found that the ALKBH family molecules also possess enzymatic activity that regulates RNA base modifications. We are focusing on these ALKBH family molecules to elucidate their functions in cancer cells.

Cancer cells release characteristic RNA and protein-encapsulated vesicles (extracellular vesicles) to the outside of the cells. Extracellular vesicles have been shown to regulate proliferation and distant metastasis of cancer cells, as well as the immune system in a cancer-dominant manner. In this study, we will utilize postoperative cancer specimens to elucidate the full picture. Furthermore, by creating human antibodies specific for cancer extracellular vesicles, we aim to apply them to antibody drugs for cancer.