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Faculty Members


Molecular and Cellular Physiology(Biology)

Tsujikawa KazutakeProfessor

1984 Master of Pharmacy, Graduate School of Pharmaceutical Sciences, Osaka University,
1984 Fujisawa Pharmaceutical Co.,Ltd., Researcher
1988 Faculty of Pharmaceutical Sciences, Osaka University, Research Associate
1989 Ph.D in Pharmacy, Osaka University,
1993 Dana-Farber Cancer Institute, Harvard University, Researcher
2006 Graduate School of Pharmaceutical Sciences, Osaka University, Associate Professor
2012- Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Professor
2016- Lead Exploration Unit, Drug Innovation Center, Director
2017- Compound Library Screening Center, Director

Research theme

Elucidating the function of epitranscriptomics in development, growth to aging

In the process from development to aging of an individual, not only the control of DNA acquired modifications (epigenetics) but also the dynamic changes in RNA acquired modifications (epitranscriptomics) and the subsequent protein translation control mechanisms are thought to play an ingenious function. In this study, we will explore law of life by analyzing the spatio-temporal and comprehensive variation of RNA modifications and elucidating their functions.

Innovative cancer drug discovery

Using primary cultured cells derived from postoperative clinical cancer specimens and tumors transplanted in mice, we will explore molecules involved in cancer development and malignant transformation. Furthermore, we will discover small molecule compounds that can control the functions of these molecules by making full use of AI, etc., and develop innovative therapeutic drugs for cancer.

Functional analysis of AlkB homolog (ALKBH) family molecules in cancer

The ALKBH family molecules are human proteins with domains similar to the E. coli protein AlkB. We were the first in the world to identify the ALKBH family molecules and also found that they are highly expressed in cancer. Furthermore, we found that the ALKBH family molecules also possess enzymatic activity that regulates RNA base modifications. We are focusing on these ALKBH family molecules to elucidate their functions in cancer cells.

Elucidation of the function of cancer extracellular vesicles and creation of anti-cancer extracellular vesicle antibodies

Cancer cells release characteristic RNA and protein-encapsulated vesicles (extracellular vesicles) to the outside of the cells. Extracellular vesicles have been shown to regulate proliferation and distant metastasis of cancer cells, as well as the immune system in a cancer-dominant manner. In this study, we will utilize postoperative cancer specimens to elucidate the full picture. Furthermore, by creating human antibodies specific for cancer extracellular vesicles, we aim to apply them to antibody drugs for cancer.

Representative achievements

ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
Sci Rep., 2021, 11(1):8677.

Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS
J Pharm Biomed Anal., 2021, 197:113943.

Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells
FEBS Lett., 2021, 595(19):2522-2532.

Pharmacological Inhibition of miR-130 family suppresses bladder tumor growth by targeting various oncogenic pathways via PTPN1
Int J Mol Sci., 2021, 22(9):4751.

Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer
Oncol Rep., 2021, 45(1):309-316.

Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF1 signaling
Cancer Res., 2021, 81(15):4014-4026.

The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver
FASEB J., 2020, 34(6):8125-8138.

RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis
Lab Invest., 2020, 100(5):738-750.

MicroRNA-92b-3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma
Cancer Sci., 2020, 111(4):1146-1155.

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses
Immunity., 2019, 51(4):709-723.e6.