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Bioorganic Chemistry(Chemistry)

Ren QinSpecially Appointed Researcher

April 2007-March 2009 Gifu University, Graduate School of Engineering, Department of Applied Science
April 2011-September 2014, Gifu University, United Graduate School of Drug Discovery and Medical Information Sciences, Department of Drug Discovery Science

Work Experience
October 2014-November 2014 Special Cooperation Researcher, Department of Drug Discovery Science, Graduate School of Drug Discovery and Medical Information Sciences, Gifu University
December 2014-November 2017 Special Research, RIKEN Center for Life Science Technology
December 2017-March 2018 Researcher, RIKEN Center for Life Science Technology
April 2018-September 2021 Researcher, RIKEN Center for Biosystems Dynamics Research (organizational revision)
October 2021- Project Researcher, Osaka University, Graduate School of Pharmaceutical Sciences, Department of Bioorganic Chemistry

Research theme

Optimization of oligonucleotides production protocol

"Nucleic acid drugs" based on oligonucleotides have attracted much attention as a new drug modality for treatment of genetic diseases that have been difficult to modulate with conventional approaches. Conventional nucleic acid drug development has problems with in vivo stability and delivery to target tissues, but with the advancement of modified nucleic acid technology and drug delivery system (DDS), the advanced oligonucleotides with much higher efficacy, safety and excellent pharmacokinetic properties are being achieved. Oligonucleotides are generally synthesized by repeating extension reactions on a solid-phase carrier, then cut out from the carrier, purified by column chromatography and ultrafiltration. For producing oligonucleotides with high-quality, it is very important and challenging work to remove the impurities generated in each reaction steps, which usually having similar molecular size and properties as target product. Therefore, I am engaged in study of protocol optimization for oligonucleotide production.

Representative achievements

Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides, Qin Ren, Kana Tsunaba, Yoshiaki Kitamura, Remi Nakashima, Aya Shibata, Masato Ikeda, Yukio Kitade, Bioorganic & Medicinal Chemistry Letters, 24 (6), 1519-1522 (2014).

Improved immuno-PET imaging of HER2-positive tumors in mice: Urokinase injection-triggered clearance enhancement of 64Cu-trastuzumab, Qin Ren, Kohta Mohri, Shota Warashina, Yasuhiro Wada, Yasuyoshi Watanabe, Hidefumi Mukai, Molecular Pharmaceutics 16 (3), 1065-1073 (2019).

Imaging contrast improvement strategy of immunoPET by enzyme injection-triggered radioisotope clearance enhancement, Kohta Mohri, Qin Ren, Hidefumi Mukai, JSMI Report Vol.12 No.1,37-40.