Research
Faculty Members
Bioorganic Chemistry（Chemistry）
Islam Md ArifulSpecially Appointed Assistant Professor
Currently, I am working as an Specially appointed assistant professor at the Graduate School of Pharmaceutical Science at Osaka University, Japan since October 2018. I have completed my Bachelor of Pharmacy and Master of Pharmacy from the University of Dhaka, Bangladesh. Additionally, I obtained my PhD in Bioorganic Chemistry from Osaka University in 2017. Prior to my current position, I had acquired over 6 years of teaching experience in various universities in Bangladesh. My main research area is nucleic acid chemistry with a particular focus on antisense drug discovery. My research interests also include the synthesis of novel nucleotide analogues, and the characterization, and evaluation, of their biological properties.
Research theme
Nucleic acid Chemistry and, therapeutics.
Chemically modified nucleic acid analogues that resemble naturally occurring DNA and RNA, are widely employed in biochemical research and medicine. So in our research, we are trying to design, synthesis and characterized novel nucleoside analogues for oligonucleotide therapeutics. Expecting these molecules have enhance properties to develop medicine.
Organ targeted drug delivery development
In this research project, we are trying to develop some antisense oligonucleotide therapeutics, which can specifically target some specific organ of the body. By conjugating oligonucleotide with suitable ligand we can achieved this purpose.
Biological assay
The synthesized molecules required characterization and evaluation their properties. So, we perform several in vitro and in vivo biophysical properties evaluation in our laboratory or with the help of our collaborators.
Bioactivity guided screening of medicinal plants available in Bangladesh
During my earlier research carrier, I have been working on phytochemistry of several medicinal plants in Bangladesh. I still have some collaboration with my fellow researchers. We are trying to screening the traditional medicinal plants used in Bangladesh. We evaluate their medicinal properties in different In vitro and In vivo models by using different conventional methods.
Representative achievements
Rahman MA, Hossain MG, Singha AC, Islam MS and Islam MA, A Retrospective Analysis of Influence of Environmental/Air Temperature and Relative Humidity on SARS-CoV-2 Outbreak. Journal of Pure and Applied Microbiology, 2020, 14(3), 1705-1714
Islam MA, Fujisaka A, Kawakami J, Yamaguchi T, Obika S. Different reactivity of Sp and Rp isomers of phosphorothioate-modified oligonucleotides in a duplex structure. Bioorg. Med. Chem. Lett., 2020, 30,1271663.
Obika S, Yamaguchi T, Habuchi T, Kato G, Inoue T, Yoshida T, Islam MA. 5’-modified nucleosides and nucleotides. PCT/JP2020/005095 (Feb 10, 2020).
Islam MA, Fujisaka A, Mori S, Ito KR, Yamaguchi T, Obika S. Synthesis and biophysical properties of 5’-thio-2’,4’-BNA/LNA oligonucleotide. Bioorg. Med. Chem., 2018, 26(12), 3634-3638.
Islam MA, Waki R, Fujisaka A, Ito KR, Obika S. In vitro and in vivo biophysical properties of oligonucleotides containing 5’-thio nucleosides. Drug Discov. Ther. 2016, 10(5), 263-270.
Ghosh A, Banik S and Islam MA. In vitro thrombolytic, anthelmintic, anti-oxidant and cytotoxic activity with phytochemical screening of methanolic extract of Xanthium indicum leaves. Bangladesh J Pharmacol., 2015, 10, 854-859.
Hussain F, Islam MA, Bulbul L, Moghal MMR and Hossain MS. In vitro thrombolytic potential of root extracts of four medicinal plants available in Bangladesh. Anc. Sci. Life, 2014, 33,162–164.
Islam MA, Mahmud ZA, Rahman SMA, Md. Monirujjaman and Saha SK: Evaluation of Thrombolytic activity and Brine Shrimp Lethality Bioassay of Methanol extract of stems of Tinospora crispa. Int. J. Pharm. Sci. Res., 2013, 4, 1148-1153.
Rahman SMA, Baba T, Kodama T, Islam MA, Obika S. Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides. Bioorg. Med. Chem., 2012, 20(13), 4098–4102.
