大阪大学大学院 薬学研究科
生物有機化学分野チャンネル
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2022
■論文
Structure-activity Relationships of Anti-microRNA Oligonucleotides Containing Cationic Guanidine-Modified Nucleic Acids
T. Takegawa-Araki, S. Kumagai, K. Yasukawa, M. Kuroda, T. Sasaki, S. Obika
J. Med. Chem., 2022, 65, 2139–2148.

Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides
R. Yamaji, O. Nakagawa, Y. Kishimoto, A. Fujii, T. Matsumura, T. Nakayama, H. Kamada, T. Osawa, T. Yamaguchi, S. Obika
Bioorg. Med. Chem., 2022, 72, 116972

Synthesis, duplex-forming ability, and nuclease resistance of oligonucleotides containing a thymidine derivative with a 1-oxaspiro[4.5]decane skeleton
T. Osawa, N. Yano, H. Aoyama, S. Obika
Chem. Pharm. Bull., 2022, 70(10), 699–706

Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis
R. Kita, T. Osawa, S. Obika
RSC Chem. Biol., 2022, 3(6), 728–738

Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials
F. Hussain, F. I. Rahman, P. Saha, A. Mikami, T. Osawa, S. Obika and S. M. A. Rahman
Molecules, 2022, 27(11), 3499

Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension
H. Yasuhara, T. Yoshida, K. Sasaki, S. Obika, T. Inoue
Mol. Diagn. Ther., 2022, 1, 117

Physicochemical property evaluation of modification oligonucleotides by traveling-wave ion mobility mass spectrometry
S. Omuro, T. Yamaguchi, T. Kawase, M. Terasaki, K. Hirose, S. Obika
Rapid Commun. Mass Spectrom., 2022, 36, e9279
■著書
4.3 核酸の分析
大澤昂志、小比賀聡
医薬品開発のための分光法, 2022, 197–206
2021
■論文
Identification of Potent and Selective Inhibitors of Fat Mass Obesity Associated Protein Using a Fragment-Merging Approach
M. Prakash, Y. Itoh, Y. Fujiwara, Y. Takahashi, Y. Takada, P. Mellini, E. E. Elboray, M. Terao, Y. Yamashita, C. Yamamoto, T. Yamaguchi, M. Kotoku, Y. Kitao, R. Singh, R. Roy, S. Obika, M. Oba, D. O. Wang, T. Suzuki
J. Med. Chem., 2021, 64, 15810

Synthesis and duplex-forming ability of oligonucleotides modified with 4'-C,5'-C-methylene-bridged nucleic acid (4',5'-BNA)
T. Yamaguchi, C. Yamamoto, M. Horiba, H. Aoyama, S. Obika
Bioorg. Med. Chem., 2021, 46, 116359

Enhanced duplex- and triplex-forming ability and enzymatic resistance of oligodeoxynucleotides modified by a tricyclic thymine derivative
Y. Kishimoto, A. Fujii, O. Nakagawa, S. Obika
Org. Biomol. Chem., 2021, 19, 8063

2′,4′-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance
Y. Kishimoto, O. Nakagawa, A. Fujii, K. Yoshioka, T. Nagata, T. Yokota, S. Obika
Chem. Eur. J., 2021,27, 2427

Azobenzene-modified DNA Aptamers Evolved by Capillary Electrophoresis (CE)-SELEX Method
K. Morihiro, O. Hasegawa, Y. Kasahara, S. Mori, T. Kasai, M. Kuwahara, S. Obika
Bioorg. Med. Chem. Lett., 2021, 31, 127607

α-Synuclein Dynamics in Induced Pluripotent Stem Cell-derived Dopaminergic Neurons from a Parkinson’s Disease Patient (PARK4) with SNCA Triplication
H. Fukusumi, K. Togo, M. Sumida, M. Nakamori, S. Obika, K. Baba, T. Shofuda, D. Ito, H. Okano, H. Mochizuki, Y. Kanemura
FEBS Open Bio, 2021, 11, 354

Crystallographic Structure of Novel Types of AgI-Mediated Base Pairs in Non-canonical DNA Duplex Containing 2′-O,4′-C-Methylene Bridged Nucleic Acids
O. Nakagawa, H. Aoyama, A. Fujii, Y. Kishimoto, S. Obika
Chem. Eur. J., 2021, 27, 3842

Design and In Vitro Evaluation of Splice-switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-bridged Nucleic Acids, and Guanidine-bridged Nucleic Acids
T. Shimo, Y. Nakatsuji, K. Tachibana, S. Obika
Int. J. Mol. Sci., 2021, 22, 3526

■著書
各論① 核酸医薬の化学
大澤昂志、小比賀聡
BIO Clinica, 2021, 36, 7

核酸医薬毒性機序概論
三上敦士、小比賀聡
実験医学(増刊:本領を発揮する創薬モダリティ), 2021, 39, 145
大阪大学大学院 薬学研究科 生物有機化学分野
〒565‐0871 大阪府吹田市山田丘1-6
TEL: 06-6879-8200    FAX: 06-6879-8204
obika@phs.osaka-u.ac.jp