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医薬合成化学分野（化学薬学領域）

村井健一講師

2003年　大阪大学薬学部総合薬学科　卒業
2008年　大阪大学大学院薬学研究科分子薬科学専攻博士課程　修了
学位：博士（薬学）
専門分野：有機合成化学

研究テーマ

生物活性化合物の合成・設計・評価

アミン化合物の特性を生かした新反応の開発

新規有機分子触媒の開発と応用

代表的な業績

Total Synthesis and Biological Evaluation of the Potent HIV Latency-Reversing Agent Ansellone A and its Analogues
Mizushi Yanagihara, Kenichi Murai, Naoki Kishimoto, Towa Abe, Shogo Misumi, Mitsuhiro Arisawa
Org. Lett., 2021, 23,1720-1725.

URL:https://doi.org/10.1021/acs.orglett.1c00151

Oxidative Rearrangement of Primary Amines Using PhI(OAc)(2) and Cs2CO3
Wataru Yamakoshi, Mitsuhiro Arisawa, Kenichi Murai
Org. Lett., 2019, 21, 3023-3027.

URL:https://doi.org/10.1021/acs.orglett.9b00559

Oxidative Rearrangement of Secondary Amines Using Hypervalent Iodine(III)-Reagent
Kenichi Murai, Tetsuya Kobayashi, Makoto Miyoshi, Hiromichi Fujioka
Org. Lett., 2018, 20, 2333-2337.

URL:https://doi.org/10.1021/acs.orglett.8b00675

Total Synthesis of Terpenoids Employing a "Benzannulation of Carvone" Strategy: Synthesis of (-)-Crotogoudin
Peter Finkbeiner, Kenichi Murai, Michael Roepke, Richmond Sarpong
J. Am. Chem. Soc., 2017, 139, 11349-11352.

URL:https://doi.org/10.1021/jacs.7b06823

Oxidative Rearrangement via in Situ Generated N-Chloroamine: Synthesis of Fused Tetrahydroisoquinolines
Kenichi Murai, Kei Matsuura, Hiroshi Aoyama, Hiromichi Fujioka
Org. Lett., 2016, 18, 1314-1317.

URL:https://doi.org/10.1021/acs.orglett.6b00233

Enantioselective iodolactonization of allenoic acids
Kenichi Murai, Nozomi Shimizu, Hiromichi Fujioka
Chem. Commun., 2014, 50, 12530-12533.

URL:https://doi.org/10.1039/c4cc05414h

Kinetic Resolution of beta-Substituted Olefinic Carboxylic Acids by Asymmetric Bromolactonization
Kenichi Murai, Tomoyo Matsushita, Akira Nakamura, Norimichi Hyogo, Junki Nakajima, Hiromichi Fujioka
Org. Lett., 2013, 15, 2526-2529.

URL:https://doi.org/10.1021/ol401007u

C3-Symmetric Trisimidazoline-Catalyzed Enantioselective Bromolactonization of Internal Alkenoic Acids
Kenichi Murai, Akira Nakamura, Tomoyo Matsushita, Masato Shimura, Hiromichi Fujioka
Chem. Eur. J., 2012, 18, 8448-8453.

URL:https://doi.org/10.1002/chem.201200647

Oxidative Rearrangement of Spiro Cyclobutane Cyclic Aminals: Efficient Construction of Bicyclic Amidines
Kenichi Murai, Hideyuki Komatsu, Ryu Nagao, Hiromichi Fujioka
Org. Lett., 2012, 14, 772-775.

URL:https://doi.org/10.1021/ol203313n

Asymmetric Bromolactonization Catalyzed by a C3-Symmetric Chiral Trisimidazoline
Kenichi Murai, Tomoyo Matsushita, Akira Nakamura, Shunsuke Fukushima, Masato Shimura, Hiromichi Fujioka
Angew. Chem. Int. Ed., 2010, 49, 9174-9177.

URL:https://doi.org/10.1002/anie.201005409

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