研究関連

独自の研究・技術開発により生活者にお役立ちします

　これまでにマンダムでは、ヒトやヒト細胞を対象とした基礎研究が元となって数々の独自商品が発売
されており、生活者の快適な生活にお役立ちしています。

2022年

Establishment and characterization of immortalized sweat gland myoepithelial cells.
Hayakawa T, Fujita F*, Okada F, Sekiguchi K.
Sci Rep Jan ,7;12(1):7 (2022)

2021年

Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis.
Defri Rizaldy, Manami Toriyama, Hiroko Kato, Runa Fukui, Fumitaka Fujita, Motoki Nakamura, Fumihiro Okada, Akimichi Morita, Ken J Ishii.
Exp Dermatol, 30, 792-803 (2021)

Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential.
Manami Toriyama, Ken J Ishii.
Front Cell Dev Biol, 621318 (2021)

Metabolomic Alteration of Oral Keratinocytes and Fibroblasts in Hypoxia.
Kato H, Sugimoto M, Enomoto A, Kaneko M, Hara Y, Saito N, Shiomi A, Ohnuki H, Izumi K.
J. Clin. Med., 10(6), 1156-1167 (2021)

Comparison of Different Temperature Conditions for Microbial Enumeration of Aspergillus brasiliensis in the Preservative Efficacy Test.
Usukura J
Biocontrol Sci,in press (2021)

2020年

Factors Affecting Reduction in Preservative Efficacy in Nonwoven Fabrics.
Usukura J*, Endo Y, Mune M
Biocontrol Sci, 25(3), 149-157 (2020)

Molecular Mechanisms of Sensory Perception on Skin Surface and the Applications for Cosmetics.
Fujita F
J. Soc. Cosmet. Chem. Jpn, 54(3), 225-228 (2020)

2018年

Hypotonicity-induced cell swelling activates TRPA1.
Fujita F*, Uchida K, Takayama Y, Suzuki Y, Takaishi M, Tominaga M
J Physiol Sci, 68(3), 431-440 (2018)

An Offensive Defense: Minimizing Preservatives, Maximizing Protection and Resources.
Araki H, Hamada S, Toshima Y, Kawazoe Y, Otani M, Suzuki R, Usukura J, Ookawa M
Cosmet Toilet Mag, Mar., 64-78(2018)

2017年

Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining.
Kurata R, Futaki S, Nakano I, Fujita F, Tanemura A, Murota H, Katayama I, Okada F, Sekiguchi K.
PLoS One, 12, e0178709 (2017)

Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
Toriyama Ma, Toriyama Mi, Wallingford JB and Finnell RH.
FASEB J, 31, 3622-3635 (2017)

2016年

Reciprocal effects of capsaicin and menthol on thermo-sensation through regulated activities of TRPV1 and TRPM8.
Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, Fujita F*, Tominaga M,
J Physiol Sci, 66, 143-155 (2016)

The influence of humidity on the transfer of scalp sebum to hair.
Tsumura A, Saito K, Fujii N, Fujita F, Hisahara J, Ohno K
J. Soc. Cosmet. Chem. Jpn, 50, 33-40 (2016)

2015年

Cold perception on skin surface through thermo- receptors. A review
Fujita F*, Takaishi M
Household and Personal Care Today, 10, 24-26 (2015)

Evaluation of the Comfortable Cooling Sensation for the Development of Body Care Products
Shimada T, Matsui H, Sawada M, Takaishi Fujita F
Oleoscience, 15, 415-422 (2015)

2014年

Effect of the application of facial cleansing wipes on male skin conditions.
Shimada T, Saito K, Takaishi M, Usukura J, Yamaguchi A, Fujita F, Shimizu M
J. Soc. Cosmet. Chem. Jpn, 48(4), 306-311 (2014)

Isolation and characterization of sweat gland myoepithelial cells from human skin.
Kurata R, Futaki S, Nakano I, Tanemura A, Murota H, Katayama I, Sekiguchi K.
Cell Struct Funct., 39, 101-112 (2014)

Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity.
Takaishi M, Uchida K, Fujita F*, Tominaga M,
J Physiol Sci, 64, 47-57 (2014)

2013年

Ambient temperature affects the temperature threshold for TRPM8 activation through interaction phosphatidylinositol 4,5-bisphosphate.
Fujita F*, Uchida K, Takaishi M, Sokabe T, Tominaga M,
J Neurosci, 33, 6154-6159 (2013)

2012年

Transient receptor potential channels in sensory irritation.
Fujita F
Household and Personal Care Today, 7, 21-24 (2012)

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Takaishi M, Fujita F, Uchida K, Yamamoto S, Sawada Shimizu M, Hatai Uotsu C, Shimizu M, Tominaga M,
Mol Pain, 8, 86 (2012)

Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.
Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M.
Pflugers Arch., 463, 549-59 (2012)

Establishment of a microplate-formatted cell-based immunoassay for rapid analysis of nucleotide excision repair ability in human primary cells.
Nishinaga M, Kurata R, Onishi K, Kuriyama K, Wakasugi M, Matsunaga T.
Photochem Photobiol., 88, 356-362 (2012)

2010年

Inhibition of the CXCR3-mediated pathway suppresses ultraviolet ray B-induced pigmentation and erythema in skin.
Kurata R, Fujita F, Onishi K, Kuriyama K, Kawamata S.
Br J Dermatol, 163, 593-602 (2010)

Significance of hair-dye base-induced sensory irritation.
Fujita F, Azuma T, Tajiri M, Okamoto H, Sano M, Tominaga M,
Int J Cosmet Sci., 32, 217-224 (2010)

2008年

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice.
Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M.
J Clin Invest., 118, 4049-4057 (2008)

The Effect of Triclosan and 3-methyl-4-isopropylphenol in Combination on Axillary Microflora
Endo, Y., Okamoto, H., Okada, F.
Boukin Boubai., 36(10), 653-660 (2008)

2007年

Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels.
Fujita F, Moriyama T, Higashi T, Shima A, Tominaga M.
Br J Pharmacol., 151,153-60 (2007)

1999年

Calorimetric Study of the Antimicrobial Action of Various Polyols Used for Cosmetics and Toiletries
Aono, A., Takahashi, K., Mori, N., Shimizu, H., Kobayashi, A., Fujiwara, N., Okada, F.
Netsu Sokutei., 26(1), 2-8 (1999)

Calorimetric Analysis of Antimicrobial Effect of p-hydroxybenzoic Acid Alkyl Esters
Okada, F., Kobayashi, A., Fujiwara, N., Arimoto, N., Takahashi, K.
Biocontrol Science, 4, 67-73 (1999)

Bacteriostatic and Bactericidal Actions of Antimicrobial Drugs Studies by Microbial Calorimetry
Okada, F., Kobayashi, A., Fujiwara, N., Takahashi, K.
Biocontrol Science, 4, 35-39 (1999)

1998年

Microbial Calorimetry of Supported Cultures and Its Application to the Study of Antimicrobial Action
Okada, F., Kobayashi, A., Fujiwara, N.., Takahashi, K.
Biocontrol Science, 3, 79-85 (1998)

Quantitative Analysis of Antimicrobial Actions of Drugs Studied by Microbial Calorimetry
Okada, F.
Netsu Sokutei., 25(4), 132-137 (1998)

Simplified, Time-saving Microbial Tests for Cosmetics and Toiletories
Okada, F.
J. Soc. Cosmet. Chem. Jpn,., 32(2), 131-139 (1998)

1993年

Preservative Evaluation of Cosmetics and Toiletories by Microbial Calorimetry
Okada, F., Fujiwara, N., Matsuyama, K., Takahashi, K.
J. Soc. Cosmet. Chem. Jpn., 27(3), 242-248 (1993)