研究業績
原著論文
2023年
- H. Uchiyama, K. Ban, S. Nozaki, Y. Ikeda, T. Ishimoto, H. Fujioka, M. Kamiya, R. Amari, H. Tsujino, M. Arai, S. Yamazoe, K. Maekawa, T. Kato, M. Doi, K. Kadota, Y. Tozuka, N. Tomita, H. Sajiki, S. Akai, Y. Sawama,
Impact of Multiple H/D Replacement on the Physicochemical Properties of Flurbiprofen.
RSC Med. Chem. (2023) Accepted
- E. Julianti, M. Azhari, M. Singgih, F. S. Dzurriyyah, M. Y. Putra, J. Lin, A. Kimishima, M. Arai,
Cytotoxic activity of cordycepin produced by marine‑derived fungus Emericella sp. against HT29 human colon cancer cell lines.
Arch. Microbiol. (2023) 205, 378.
- A. Lail, F. Setiawan, W. Widyastuti, M. R. Fadhilah, A. Setiawan, N. L. G. R. Juliasih, W. A. Setiawan, E. Apriliana, P. Ahmadi, M. Arai, J. Hendri*,
Exploration and Biorefinery Antimicrobial Agent through Solid State Fermentation from Indonesia’s Marine Actinomycetes.
Fermentation (2023) 9(4), 334.
- N. Sirimangkalakitti, K. Harada, M. Yamada, M. Arai*, M. Arisawa*,
A new tetracyclic bromopyrrole-imidazole alkaloid through direct chemical diversification of natural product extract from marine sponge Petrosia (Strongylophora) sp.
Molecules (2023) 28(1), 143.
2022年
- J. Mukomura, H. Nonaka, H. Sato, M. Kishimoto, M. Arai, N. Kotoku,
Anti-Mycobacterial N-(2-Arylethyl)quinolin-3-amines Inspired by Marine Sponge-Derived Alkaloid.
Molecules (2022) 27(24), 8701.
- M. Yamada, Y. Hirose, B. Lin, M. Fumimoto, K. Nunomura, S. Natchanun, N. Takahashi, Y. Ohki, M. Sako, K. Murai, K. Harada, M. Arai, S. Suzuki, T. Nakamura, J. Haruta, M. Arisawa,
Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues.
ACS Med. Chem. Lett. (2022) 13(10), 1582-1590.
- W. Widyastuti, F. Setiawan, C. A. Afandy, A. Irawan, A. Laila, N. L. G. R. Juliasih, W. A. Setiawan, M. Arai, J. Hendri, A. Setiawan,
Antifungal Agent Chitooligosaccharides Derived from Solid-State Fermentation of Shrimp Shell Waste by Pseudonocardia antitumoralis 18D36-A1.
Fermentation (2022) 8(8), 353.
- A. Kimishima, H. Kato, K. Nakaguro, M. Arai,
Single-step construction of an acetoxypyrroloindole skeleton via tandem iodocyclization/acetoxylation of indoles.
Org. Biomol. Chem. (2022) 20, 5397-5401.
- M. Muraoka, M. Ohno, T. Nakai, H. Matsuura, K. Nagano, M. Arai, H. Uyama, Y. Hirata, K. Hirata,
Gamma-glutamylcysteine Production using Phytochelatin Synthase-like Enzyme Derived from Nostoc sp. Covalently Immobilized on a Cellulose Carrier.
Biol. Pharm. Bull. (2022) 45(8), 1191-1197.
- K. Ikoma, M. Takahama, A. Kimishima, Y. Pan, M. Taura, A. Nakayama, M. Arai, N. Takemura, T. Saitoh,
Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung.
Int. Immunol. (2022) 34(10), 493-504.
- A. Setiawan, R. Lutfiah, N. L. G. R. Juliasih, W. A. Setiawan, J. Hendri, M. Arai,
Antibacterial activity of EtOAc extract from marine-derived fungus Aspergillus nomiae A12-RF against clinical pathogen bacteria, Staphylococcus aureus.
AACL Bioflux (2022) 15(3), 1413-1421.
- F. Mitani, J. Lin, T. Sakamoto, R. Uehara, T. Hikita, T. Yoshida, A. Setiawan, M. Arai*, C. Oneyama*,
Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.
Sci. Rep. (2022) 12, 6674.
- A. Setiawan, F. Setiawan, N. L. G. R. Juliasih, W. Widyastuti, A. Laila, W. A. Setiawan, F. M. Djailani, M. Mulyono, J. Hendri, M. Arai,
Fungicide activity of Culture Extract from Kocuria palustris 19C38A1 against Fusarium oxysporum.
J. Fungi (2022) 8(3), 280.
- T. Fujita, J. Lin, A. Kimishima, M. Arai, H. Takikawa, Y. Ogura,
Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A–D as Cytotoxic Agents against Human Pancreatic Carcinoma PANC-1 Cells.
Biosci. Biotechnol. Biochem. (2022)86(5), 590-595.
- Y. Sumii, K. Kamiya, T. Nakamura, K. Tanaka, T. Kaji, N. Kotoku, M. Arai,
Structure activity relationship study of 3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance to create probe molecule for detecting target protein.
Mar. Drugs (2022) 20(2), 98.
- M. Muraoka, S. Yoshida, M. Ohno, H. Matsuura, K. Nagano, Y. Hirata, M. Arai, K. Hirata,
Reactivity of γ-glutamyl-cysteine with intracellular and extracellular glutathione metabolic enzymes.
FEBS Lett. (2022) 596(2), 180-188.
2021年
- A. Setiawan, W. Widyastuti, A. Irawan, O. S. Wijaya, A. Laila, W. A. Setiawan, N. L. G. R. Juliasih, K. Nonaka, M. Arai, J. Hendri,
Fermentation Shrimp Shell Waste in Solid State using Pseudonocardia carboxydivorans 18A13O1 to Producing Bioactive Metabolites.
Fermentation (2021) 7(4), 247.
- A. Kimishima, H. Saito, V. Petrova, M. Arai,
Asymmetric Formal Synthesis of Trichodermamide B and C.
Synlett (2021) 32(18), 1865-1868.
- M. Yamada, R. Ohta, K. Harada, T. Takehara, H. Haneoka, Y. Murakami, T. Suzuki, Y. Ohki, N. Takahashi, T. Akiyama, N. Sirimangkalakitti, M. Sako, K. Murai M. Arai, M. Arisawa,
Product Selective Reaction Controlled by the Combination of a Palladium Nanoparticles, Continuous Microwave Irradiation, and a Co-existing Solid; Ligand-Free Buchwald–Hartwig Amination vs Aryne Amination.
Green Chemistry (2021) 143(28), 10853-10859.
- C. Okajima, N. Imakawa, K. Nagano, M. Arai, M. Arisawa, M. Muraoka, H. Tsujino, Y. Hirata, K. Hirata,
Inhibitory activity and proposed binding model of γ-glutamyl cysteine, the precursor of glutathione, on angiotensin converting enzyme.
BPB reports (2021) 4 (4), 116-119.
- H. Matsumoto, T. Hisa, K. Toda, R. Ishida, A. Setiawan, M. Arai, N. Kotoku,
Fasciospyrinadinone and Fasciospyrinadinol, Novel 3-Alkylpyridine Sesquiterpenoids from An Indonesian Marine Sponge, as Selective Growth Inhibitors of the Cancer Cells Under Nutrient Starvation.
Heterocycles (2021) 103 (2), 827-838.
- W. A. Abdel-Naime, J. R. Fahim, M. A. Fouad, M. Arai*, M. S. Kamel*,
Anti-dormant mycobacterial activity of Melissa officinalis L. (Lemon balm).
J. Adv. Biomed. & Pharm. Sci. (2021) 4 (2), 95-97.
2020年
- W. A. Abdel-Naime, A. Kimishima, A. Setiawan, J. R. Fahim, M. A. Fouad, M. S. Kamel, M. Arai,
Mitochondrial Targeting in an Anti-austerity Approach involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp.
Mar. Drugs (2020) 18 (11), E555.
- R. Tang, D. Zhou, A. Kimishima, A. Setiawan, M. Arai,
Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation.
J. Antibiot. (2020) 73 (12), 873-875.
- Y. Sumii, N. Kotoku, C. Han, K. Kamiya, A. Setiawan, C. Vilchèze, W. R. Jacobs Jr., M. Arai,
3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis.
Tetrahedron Lett. (2020) 61 (22), 151924.
- A. M. Zaher, J. Lin, M. Arai,
Cytotoxic activity of abietane-type diterpenes isolated from Taxodium distichum against cancer cells adapted to nutrient-starved conditions.
Nat. Prod. Commun. (2020) 15 (3), 1-6.
- M. Tanuma, A. Kasai, K. Bando, N. Kotoku, K. Harada, M. Minoshima, K. Higashino, A. Kimishima, M. Arai, Y. Ago, K. Seiriki, K. Kikuchi, S. Kawata, K. Fujita, H. Hashimoto,
Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain.
JCI Insight, (2020) 5 (6), e133348.
- R. Tang, A. Kimishima, A. Setiawan, M. Arai,
Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation.
J. Nat. Med. (2020) 74 (2), 495-500.
- A. Kimishima, H. Saito, A. Yamaguchi, M. Arai,
A stereoselective construction of a cis-1,2-oxazadecaline skeleton using a substrate-controlled intramolecular oxy-Michael addition of tyrosine-derived hydroxylamines.
Tetrahedron Lett., (2020) 61 (4), 151412.
2019年
- H. H. H. Mohammed, S. H. Abbas, El-Shimaa M. N. Abdelhafez, J. M. Berger, S. Mitarai, M. Arai, Gamal El-Din A. A. Abuo-Rahma,
Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives.
Monatshefte für Chemie/Chemical Monthly (2019) 150 (10), 1809-1824.
- R. Tang, A. Kimishima, R. Ishida, A. Setiawan, M. Arai,
Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.
J. Nat. Med. (2020) 74 (1), 153-158.
- T. Jomori, Y. Hara, M. Sasaoka, K. Harada, A. Setiawan, K. Hirata, A. Kimishima, M. Arai,
Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger.
J. Nat. Med. (2020) 74 (1), 76-82.
- T. Jomori, A. Setiawan, M. Sasaoka, M. Arai,
Cytotoxicity of new diterpene alkaloids, ceylonamides G-I, isolated from Indonesian marine sponge of Spongia sp.
Nat. Prod. Commun. (2019) 14 (6), 1-7.
- T. Kawachi, S. Tanaka, A. Fukuda, Y. Sumii, A. Setiawan, N. Kotoku, M. Kobayashi, M. Arai,
Target identification of the marine natural products dictyoceratin-A and -C as selective growth inhibitors in cancer cells adapted to hypoxic environments.
Mar. Drugs (2019) 17(3), E163.
- S. Ueda, H. Ikeda, T. Namba, Y. Ikejiri, Y. Nishimoto, M. Arai, T. Nihira, S. Kitani,
Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression.
J. Ind. Microbiol. Biotechnol. (2019) 46(5), 739-750.
- L.C.V. Cuong, L.T. Lien, N.P.K. Nhi, T.P. Ha, L.T. Anh, M. Arai, H.L.T. Anh,
Structural elucidation of glycosides from the seeds of Entada phaseoloides growing in Thua Thien Hue.
Vietnam J. Sci. Technol. (2019) 57(2), 170-178.
- H.H.H. Mohammed, E.M.N. Abdelhafez, S.H. Abbas, G.A.I. Moustafa, G. Hauk, J.M. Berger, S. Mitarai, M. Arai, R.M. Abd El-Baky, G.E.A. Abuo-Rahma.
Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity.
Bioorg. Chem. (2019) 88, 102952.
- H.L.T. Anh, L.B. Vinh, L.T. Lien, P.V. Cuong, M. Arai, T.P. Ha, H.N. Lin, T.T.H. Dat, L.C.V. Cuong, Y.H. Kim.
In vitro study on α-amylase inhibitory and α-glucosidase of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina.
Nat. Prod. Res. (2019) 1-7
- R. Ishida, H. Matsumoto, S. Ichii, M. Kobayashi, M. Arai, N. Kotoku,
Structure-activity relationship of biakamide, selective growth inhibitors under nutrient-starved condition from marine sponge.
Chem. Pharm. Bull. (2019) 67(3), 210-223.
2018年
- S. Ueda, S. Kitani, T. Namba, M. Arai, H. Ikeda, T. Nihira,
Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis.
J. Antibiot. (2018) 71(10), 854-861.
- D. A. Suroto, S. Kitani, M. Arai, H. Ikeda, T. Nihira,
Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis.
PLoS One. (2018) 13(1), e0190973
- I.G.U. Pait, S. Kitani, F.W. Roslan, D. Ulanova, M. Arai, H. Ikeda, T. Nihira,
Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5.
J. Ind. Microbiol. Biotechnol. (2018) 45(2), 77-87.
2017年
- K. Kamiya, M. Arai*, A. Setiawan, M. Kobayashi*,
Anti-dormant mycobacterial activity of viomellein and xanthomegnin, naphthoquinone dimers produced by marine-derived Aspergillus sp.
Nat. Prod. Commun. (2017) 12(4), 579-581.
- N. Kotoku, R. Ishida, H. Matsumoto, M. Arai, K. Toda, A. Setiawan, O. Muraoka, M. Kobayashi,
Biakamides A-D, unique polyketides from a marine sponge, act as selective growth inhibitors of tumor cells adapted to nutrient starvation.
J. Org. Chem. (2017) 82(3), 1705-1718.
- M. Arai*, D. Shin, K. Kamiya, R. Ishida, A. Setiawan, N. Kotoku, M. Kobayashi*,
Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II.
J. Nat. Med. (2017) 71(1), 44-49.
著書・総説・解説
2019年
- Masayoshi Arai,
Exploring Bioactive Marine Natural Products and Identification of Their Molecular Targets (Chapter 12).
In; Yuichi Kobayashi (Ed) Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules (2019) P.291-303 Springer-Nature, Switzerland (ISBN 978-981-13-6244-6)
2018年
- 荒井雅吉
「低酸素環境で機能する海洋天然物」
「細胞」(2018) Vol.50, No.4, 38-41.
- 荒井雅吉
「低酸素環境で機能する海洋天然物」
「アグリバイオ」 (研究者の広場) (2018) Vol.2, No.8, 54-58.
- 荒井雅吉
「海洋医薬資源からの潜在性結核菌に有効な抗菌物質の探索と標的分子解析」
「生産と技術」（研究ノート）(2018) Vol.70, No.3, 83-85.
