Members
- Professor Takumi Ueda ueda(at)phs.osaka-u.ac.jp
- Associate Professor Takuya Yoshida yo(at)phs.osaka-u.ac.jp
- Lecturer Yutaro Shiraishi shiraishi(at)phs.osaka-u.ac.jp
- one D4 student
- one D1 student
- three B6 students
- five B5 students
- five B4 students
- five B3 students
Publications
Please check the following links (Researchmap).Researches
Drug-target proteins exert their biofunctions with continuously changing their conformations.In relation to this point, NMR methods provide quantitative spatiotemporal information
on proteins under conformational equilibria, including the structure of each state, exchange rate, and population.
In addition, NMR enables the real-time observation of chemical reactions in complex mixtures where multiple components interact with one another.
X-ray crystallography and cryo-electron microscopy enable us to determine precise protein structures.
We utilize these methods to clarify the dynamic structures of drug-target proteins directly related to their biofunctions.
In addition, we are proceeding with studies for enabling us to modulate the function-related dynamic structures by drugs
and construct mathematical models by integrating the functional dynamic structures with cell biological and
biochemical real-time observation data, using machine-learning and systems biology methods.
Our studies will quantitatively explain the biological events and accelerate the drug development.
Research of each group
Alumni
- Lecturer, Graduate School of Drug Discovery Sciences Kazuki Kawahara