Members
- Professor Takumi Ueda ueda(at)phs.osaka-u.ac.jp
- Associate Professor Takuya Yoshida yo(at)phs.osaka-u.ac.jp
- Specially Appointed Senior Associate Professor Yutaro Shiraishi shiraishi(at)phs.osaka-u.ac.jp
- Assistant Professor Kazuki Kawahara kkkazuki(at)phs.osaka-u.ac.jp
- one D2 student
- one M2 student
- three B6 students
- three B5 students
- three B4 students
- three B3 students
Publications
Please check the following links (Researchmap).Researches
Drug-target proteins exert their biofunctions with continuously changing their conformations.In relation to this point, NMR methods provide quantitative spatiotemporal information
on proteins under conformational equilibria, including the structure of each state, exchange rate, and population.
X-ray crystallography and cryo-electron microscopy enable us to determine precise protein structures.
We utilize these methods to clarify the dynamic structures of drug-target proteins directly related to their biofunctions.
In addition, we are proceeding with studies for enabling us to modulate the function-related dynamic structures by drugs
and construct mathematical models by integrating the functional dynamic structures with cell biological and
biochemical real-time observation data, using machine-learning and systems biology methods.
Our studies will quantitatively explain the biological events and accelerate the drug development.
