Laboratory of advanced cosmetic science

Research

Contribution to comfortable life of all people by original research
and development

The basic research about human and human cells led to the novel cosmetic products in Mandom corp. and they contribute to comfortable life of all people.

2017

Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining.
Kurata R, Futaki S, Nakano I, Fujita F, Tanemura A, Murota H, Katayama I, Okada F, Sekiguchi K.
PLoS One, 12, e0178709 (2017)

Hypotonicity-induced cell swelling activates TRPA1.
Fujita F*, Uchida K, Takayama Y, Suzuki Y, Takaishi M, Tominaga M
J Physiol Sci, (2017) in press

Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
Toriyama Ma, Toriyama Mi, Wallingford JB and Finnell RH.
FASEB J, 31, 3622-3635 (2017)

2016

Reciprocal effects of capsaicin and menthol on thermo-sensation through regulated activities of TRPV1 and TRPM8.
Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, Fujita F*, Tominaga M,
J Physiol Sci, 66, 143-155 (2016)

The influence of humidity on the transfer of scalp sebum to hair.
Tsumura A, Saito K, Fujii N, Fujita F, Hisahara J, Ohno K
J. Soc. Cosmet. Chem. Jpn, 50, 33-40 (2016)

2015

Cold perception on skin surface through thermo- receptors. A review
Fujita F*, Takaishi M
Household and Personal Care Today, 10, 24-26 (2015)

Evaluation of the Comfortable Cooling Sensation for the Development of Body Care Products
Shimada T, Matsui H, Sawada M, Takaishi M, Fujita F
Oleoscience, 15, 415-422 (2015)

2014

Effect of the application of facial cleansing wipes on male skin conditions.
Shimada T, Saito K, Takaishi M, Usukura J, Yamaguchi A, Fujita F, Shimizu M
J. Soc. Cosmet. Chem. Jpn, 48(4), 306-311 (2014)

Isolation and characterization of sweat gland myoepithelial cells from human skin.
Kurata R, Futaki S, Nakano I, Tanemura A, Murota H, Katayama I, Sekiguchi K.
Cell Struct Funct., 39, 101-112 (2014)

Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity.
Takaishi M, Uchida K, Fujita F*, Tominaga M,
J Physiol Sci, 64, 47-57 (2014)

2013

Ambient temperature affects the temperature threshold for TRPM8 activation through interaction phosphatidylinositol 4,5-bisphosphate.
Fujita F*, Uchida K, Takaishi M, Sokabe T, Tominaga M,
J Neurosci, 33, 6154-9 (2013)

2012

Transient receptor potential channels in sensory irritation.
Fujita F
Household and Personal Care Today, 7, 21-24 (2012)

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Takaishi M, Fujita F, Uchida K, Yamamoto S, Sawada Shimizu M, Hatai Uotsu C, Shimizu M, Tominaga M,
Mol Pain, 8, 86 (2012)

Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.
Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M.
Pflugers Arch., 463, 549-59 (2012)

Establishment of a microplate-formatted cell-based immunoassay for rapid analysis of nucleotide excision repair ability in human primary cells.
Nishinaga M, Kurata R, Onishi K, Kuriyama K, Wakasugi M, Matsunaga T.
Photochem Photobiol., 88, 356-362 (2012)

2010

Inhibition of the CXCR3-mediated pathway suppresses ultraviolet ray B-induced pigmentation and erythema in skin.
Kurata R, Fujita F, Onishi K, Kuriyama K, Kawamata S.
Br J Dermatol, 163, 593-602 (2010)

Significance of hair-dye base-induced sensory irritation.
Fujita F, Azuma T, Tajiri M, Okamoto H, Sano M, Tominaga M,
Int J Cosmet Sci., 32, 217-224 (2010)

2008

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice.
Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M.
J Clin Invest., 118, 4049-4057 (2008)

The Effect of Triclosan and 3-methyl-4-isopropylphenol in Combination on Axillary Microflora
Endo, Y., Okamoto, H., Okada, F.
Boukin Boubai., 36(10), 653-660 (2008)

2007

Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels.
Fujita F, Moriyama T, Higashi T, Shima A, Tominaga M.
Br J Pharmacol., 151,153-60 (2007)

1999

Calorimetric Study of the Antimicrobial Action of Various Polyols Used for Cosmetics and Toiletries
Aono, A., Takahashi, K., Mori, N., Shimizu, H., Kobayashi, A., Fujiwara, N., Okada, F.
Netsu Sokutei., 26(1), 2-8 (1999)

Calorimetric Analysis of Antimicrobial Effect of p-hydroxybenzoic Acid Alkyl Esters
Okada, F., Kobayashi, A., Fujiwara, N., Arimoto, N., Takahashi, K.
Biocontrol Science, 4, 67-73 (1999)

Bacteriostatic and Bactericidal Actions of Antimicrobial Drugs Studies by Microbial Calorimetry
Okada, F., Kobayashi, A., Fujiwara, N., Takahashi, K.
Biocontrol Science, 4, 35-39 (1999)

1998

Microbial Calorimetry of Supported Cultures and Its Application to the Study of Antimicrobial Action
Okada, F., Kobayashi, A., Fujiwara, N.., Takahashi, K.
Biocontrol Science, 3, 79-85 (1998)

Quantitative Analysis of Antimicrobial Actions of Drugs Studied by Microbial Calorimetry
Okada, F.
Netsu Sokutei., 25(4), 132-137 (1998)

Simplified, Time-saving Microbial Tests for Cosmetics and Toiletories
Okada, F.
J. Soc. Cosmet. Chem. Jpn., 32(2), 131-139 (1998)

1993

Preservative Evaluation of Cosmetics and Toiletories by Microbial Calorimetry
Okada, F., Fujiwara, N., Matsuyama, K., Takahashi, K.
J. Soc. Cosmet. Chem. Jpn., 27(3), 242-248 (1993)