Laboratory of advanced cosmetic science


Contribution to comfortable life of all people by original research
and development

The basic research about human and human cells led to the novel cosmetic products in Mandom corp. and they contribute to comfortable life of all people.


Designing Motif-Engineered Receptors To Elucidate SignalingMolecules Important for Proliferation of Hematopoietic Stem Cells.
Ishizuka S, Lai CY, Otsu M, Nakauchi H, Nagamune T, Kawahara M.
ACS Synth Biol, 7, 1709-1714 (2018)


Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining.
Kurata R, Futaki S, Nakano I, Fujita F, Tanemura A, Murota H, Katayama I, Okada F, Sekiguchi K.
PLoS One, 12, e0178709 (2017)

Hypotonicity-induced cell swelling activates TRPA1.
Fujita F*, Uchida K, Takayama Y, Suzuki Y, Takaishi M, Tominaga M
J Physiol Sci, (2017) in press

Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
Toriyama Ma, Toriyama Mi, Wallingford JB and Finnell RH.
FASEB J, 31, 3622-3635 (2017)


Reciprocal effects of capsaicin and menthol on thermo-sensation through regulated activities of TRPV1 and TRPM8.
Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, Fujita F*, Tominaga M,
J Physiol Sci, 66, 143-155 (2016)

The influence of humidity on the transfer of scalp sebum to hair.
Tsumura A, Saito K, Fujii N, Fujita F, Hisahara J, Ohno K
J. Soc. Cosmet. Chem. Jpn, 50, 33-40 (2016)


Cold perception on skin surface through thermo- receptors. A review
Fujita F*, Takaishi M
Household and Personal Care Today, 10, 24-26 (2015)

Evaluation of the Comfortable Cooling Sensation for the Development of Body Care Products
Shimada T, Matsui H, Sawada M, Takaishi M, Fujita F
Oleoscience, 15, 415-422 (2015)


Effect of the application of facial cleansing wipes on male skin conditions.
Shimada T, Saito K, Takaishi M, Usukura J, Yamaguchi A, Fujita F, Shimizu M
J. Soc. Cosmet. Chem. Jpn, 48(4), 306-311 (2014)

Isolation and characterization of sweat gland myoepithelial cells from human skin.
Kurata R, Futaki S, Nakano I, Tanemura A, Murota H, Katayama I, Sekiguchi K.
Cell Struct Funct., 39, 101-112 (2014)

Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity.
Takaishi M, Uchida K, Fujita F*, Tominaga M,
J Physiol Sci, 64, 47-57 (2014)


Ambient temperature affects the temperature threshold for TRPM8 activation through interaction phosphatidylinositol 4,5-bisphosphate.
Fujita F*, Uchida K, Takaishi M, Sokabe T, Tominaga M,
J Neurosci, 33, 6154-9 (2013)


Transient receptor potential channels in sensory irritation.
Fujita F
Household and Personal Care Today, 7, 21-24 (2012)

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Takaishi M, Fujita F, Uchida K, Yamamoto S, Sawada Shimizu M, Hatai Uotsu C, Shimizu M, Tominaga M,
Mol Pain, 8, 86 (2012)

Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.
Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M.
Pflugers Arch., 463, 549-59 (2012)

Establishment of a microplate-formatted cell-based immunoassay for rapid analysis of nucleotide excision repair ability in human primary cells.
Nishinaga M, Kurata R, Onishi K, Kuriyama K, Wakasugi M, Matsunaga T.
Photochem Photobiol., 88, 356-362 (2012)


Inhibition of the CXCR3-mediated pathway suppresses ultraviolet ray B-induced pigmentation and erythema in skin.
Kurata R, Fujita F, Onishi K, Kuriyama K, Kawamata S.
Br J Dermatol, 163, 593-602 (2010)

Significance of hair-dye base-induced sensory irritation.
Fujita F, Azuma T, Tajiri M, Okamoto H, Sano M, Tominaga M,
Int J Cosmet Sci., 32, 217-224 (2010)


Intracellular alkalization causes pain sensation through activation of TRPA1 in mice.
Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M.
J Clin Invest., 118, 4049-4057 (2008)

The Effect of Triclosan and 3-methyl-4-isopropylphenol in Combination on Axillary Microflora
Endo, Y., Okamoto, H., Okada, F.
Boukin Boubai., 36(10), 653-660 (2008)


Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels.
Fujita F, Moriyama T, Higashi T, Shima A, Tominaga M.
Br J Pharmacol., 151,153-60 (2007)


Calorimetric Study of the Antimicrobial Action of Various Polyols Used for Cosmetics and Toiletries
Aono, A., Takahashi, K., Mori, N., Shimizu, H., Kobayashi, A., Fujiwara, N., Okada, F.
Netsu Sokutei., 26(1), 2-8 (1999)

Calorimetric Analysis of Antimicrobial Effect of p-hydroxybenzoic Acid Alkyl Esters
Okada, F., Kobayashi, A., Fujiwara, N., Arimoto, N., Takahashi, K.
Biocontrol Science, 4, 67-73 (1999)

Bacteriostatic and Bactericidal Actions of Antimicrobial Drugs Studies by Microbial Calorimetry
Okada, F., Kobayashi, A., Fujiwara, N., Takahashi, K.
Biocontrol Science, 4, 35-39 (1999)


Microbial Calorimetry of Supported Cultures and Its Application to the Study of Antimicrobial Action
Okada, F., Kobayashi, A., Fujiwara, N.., Takahashi, K.
Biocontrol Science, 3, 79-85 (1998)

Quantitative Analysis of Antimicrobial Actions of Drugs Studied by Microbial Calorimetry
Okada, F.
Netsu Sokutei., 25(4), 132-137 (1998)

Simplified, Time-saving Microbial Tests for Cosmetics and Toiletories
Okada, F.
J. Soc. Cosmet. Chem. Jpn., 32(2), 131-139 (1998)


Preservative Evaluation of Cosmetics and Toiletories by Microbial Calorimetry
Okada, F., Fujiwara, N., Matsuyama, K., Takahashi, K.
J. Soc. Cosmet. Chem. Jpn., 27(3), 242-248 (1993)