Bioorganic Chemistry Channel,
Osaka University
Osaka University
2020
■Articles
■Reviews
■Book
2019
■Articles
Theoretical Analyses and Experimental Validation of The Effects Caused by The Fluorinated Substituent Modification of DNA
J. Koseki, M. Konno, A. Asai, N. Horie, K. Tsunekuni, K. Kawamoto, S. Obika, Y. Doki, M. Mori, H. Ishii
Sci. Rep., 2019, in press
Synthesis and properties of oligonucleotides having ethynylphosphonate (EP) linkages
M. Horiba, T. Yamaguchi, S. Obika
J. Org. Chem., 2019, in press
Nucleobase Derivatives Induce In-Source Decay of Oligonucleotides as New MALDI Matrices
S. Kimura, A. Fujisaka, S. Obika
Rapid Commun. Mass Spectrom, 2019, in press
Inhibiting Guanine Oxidation and Enhancing Excess-electron-transfer Efficiency of A Pyrene-modified Oligonucleotide by Introducing An Electron-donating Group on Pyrene
T. Okuda, Y. Kawashima, Y. Kasahara, T. Takagi, J. Yamamoto, S. Iwai, S. Obika
Chem. Commun., 2019, in press
Evaluation of Off-target Effects of Gapmer Antisense Oligonucleotides Using Human Cells
T. Yoshida, Y. Naito, K. Sasaki, H. Kawaji, J. Kawai, M. Naito, H. Okuda, S. Obika, T. Inoue
Genes to Cells, 2019, in press
Effect of Modular Conjugation Strategy for N-Acetylgalactosamine-targeted Antisense Oligonucleotides
T. Yamamoto, M. Sawamura, C. Terada, K. Kashiwada, F. Wada, A. Yamayoshi, S. Obika, M. Harada-Shiba
Nucleosides, Nucleotides, Nucleic Acids, 2019, in press
Derivative Synthesis toward Enhancement of the Biophysical Properties of 2′,4′-Bridged Nucleic Acids
T. Yamaguchi, S. Obika
J. Synth. Org. Chem., 2019, 77, 994
Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties.
A. Fujii, O. Nakagawa, Y. Kishimoto, Y. Nakatsuji, N. Nozaki, S. Obika
ChemBioChem, 2019, in press
Synthesis of 2′-C,4′-C-Methyleneoxy-bridged Thymidine Derivatives and Properties of Modified Oligonucleotides
T. Osawa, H. Kim, M. Shoji, M. Saijo, M. Dohi, Y. Ito, S. Obika, Y. Hari
J. Org. Chem., 2019, 21, 13336
GREB1 Induced by Wnt Signaling Promotes Development of Hepatoblastoma by Suppressing TGFβ Signaling
S. Matsumoto, T. Yamamichi, K. Shinzawa, Y. Kasahara, S. Nojima, T. Kodama, S. Obika, T. Takehara, E. Morii, H. Okuyuama, A. Kikuchi
Nat. Commun., 2019, 10, 3882
Highly Efficient Silencing of microRNA by Heteroduplex Oligonucleotides
K. Yoshioka, T. Kunieda, Y. Asami, H. Guo, H. Miyata, K. Yoshida Tanaka, Y. Sujino, W. Piao, H. Kuwahara, K. Nishina, R. Hara, T. Nagata, S. Obika, T. Wada, T. Yokota
Nucleic Acids Res., 2019, 47, 7321
A Hydrogen Peroxide-activatable Gemcitabine Prodrug for The Selective Treatment of Pancreatic Ductal Adenocarcinoma
K. Matsushita, T. Okuda, S. Mori, M. Konno, H. Eguchi, A. Asai, J. Koseki, Y. Iwagami, D. Yamada, H. Akita, T. Asaoka, T. Noda, K. Kawamoto, K. Gotoh, S. Kobayashi, Y. Kasahara, K. Morihiro, T. Satoh, Y. Doki, M. Mori, H. Ishii, S. Obika
ChemMedChem, 2019, 14, 1384
Amido-bridged Nucleic Acid (AmNA)-modified Antisense Oligonucleotides Targeting α-Synuclein as A Novel Therapy for Parkinson’s Disease
T. Uehara, C.-J. Choong , M. Nakamori, H. Hayakawa, K. Nishiyama, Y. Kasahara, K. Baba, T. Nagata, T. Yokota, H. Tsuda, S. Obika, H. Mochizuki
Sci. Rep., 2019, 9, 7567
A Gapmer Antisense Oligonucleotide Targeting SRRM4 Is a Novel Therapeutic Medicine for Lung Cancer
M. Shimojo, Y. Kasahara, M. Inoue, S. Tsunoda, Y. Shudo, T. Kurata, S. Obika
Sci. Rep., 2019, 9, 7618
Enhancement of exon skipping activity by reduction in secondary structure content of LNA-based splice-switching oligonucleotides
T. Shimo, K. Tachibana, Y. Kawawaki, Y. Watahiki, T. Ishigaki, Y. Nakatsuji, T. Hara, J. Kawakami, S. Obika
Chem. Commun., 2019, 55, 6850-6853
Thymidine, 2-Thiothymidine, and 2-Selenothymidine: Comparison of Mismatch Discriminations
T. Habuchi, T. Yamaguchi, S. Obika
Heterocycles, 2019, 48, 832-837
1,3,9‐Triaza‐2‐Oxophenoxazine Artificial Nucleobase Forms Highly Stable Self‐base Pairs with Three AgI Ions in a Duplex
A. Fujii, O. Nakagawa, Y. Kishimoto, T. Okuda, Y. Nakatsuji, N. Nozaki, Y. Kasahara, S. Obika
Chem. Eur. J., 2019, 25, 7443-7448
Thioamide-bridged Nucleic Acid (thioAmNA) Bearing Thymine or 2-Thiothymine: Duplex Forming Ability, Base Discrimination, and Enzymatic Stability
T. Habuchi, T. Yamaguchi, S. Obika
ChemBioChem, 2019, 20, 1-9
Effective syntheses of 2’,4’-BNANC monomers bearing adenine, guanine, thymine, and 5-methylcytosine, and the properties of oligonucleotides fully modified with 2′,4′-BNANC
A. Fujisaka, Y. Hari, H. Takuma, S.M.A. Rahman, H. Yoshikawa, J. Pang, T. Imanishi, S. Obika
Bioorg. Med. Chem., 2019, 27, 1728–1741
Detection of Esterase Activity by Chromogenic and Fluorogenic Probe Based on an O-Nitrobenzoxadiazole (O-NBD) Unit
K. Okada, T. Yamaguchi, K. Dodo, M. Sodeoka, S. Obika
Bioorg. Med. Chem., 2019, 27, 1444–1448
Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
T. Harada, S. Matsumoto, S. Hirota, H. Kimura, S. Fujii, Y. Kasahara, H. Gon, T. Yoshida, T. Itoh, N. Haraguchi, T. Mizushima, T. Noda, H. Eguchi, S. Nojima, E. Morii, T. Fukumoto, S. Obika, A. Kikuchi
Mol. Cancer Ther., 2019, 18, 602
Hybridization and Mismatch Discrimination Abilities of 2′,4′-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase
T. Habuchi, T. Yamaguchi, H. Aoyama, M. Horiba, K. Ito, S. Obika
J. Org. Chem., 2019, 84, 1430-1439
High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors N3-Modified Thioflavin T Derivatives
Y. Kataoka, H. Fujita, A. Afanasyeva, C. Nagao, K. Mizuguchi, Y. Kasahara, S. Obika, M. Kuwahara
Biochemistry, 2019, 58, 493
J. Koseki, M. Konno, A. Asai, N. Horie, K. Tsunekuni, K. Kawamoto, S. Obika, Y. Doki, M. Mori, H. Ishii
Sci. Rep., 2019, in press
Synthesis and properties of oligonucleotides having ethynylphosphonate (EP) linkages
M. Horiba, T. Yamaguchi, S. Obika
J. Org. Chem., 2019, in press
Nucleobase Derivatives Induce In-Source Decay of Oligonucleotides as New MALDI Matrices
S. Kimura, A. Fujisaka, S. Obika
Rapid Commun. Mass Spectrom, 2019, in press
Inhibiting Guanine Oxidation and Enhancing Excess-electron-transfer Efficiency of A Pyrene-modified Oligonucleotide by Introducing An Electron-donating Group on Pyrene
T. Okuda, Y. Kawashima, Y. Kasahara, T. Takagi, J. Yamamoto, S. Iwai, S. Obika
Chem. Commun., 2019, in press
Evaluation of Off-target Effects of Gapmer Antisense Oligonucleotides Using Human Cells
T. Yoshida, Y. Naito, K. Sasaki, H. Kawaji, J. Kawai, M. Naito, H. Okuda, S. Obika, T. Inoue
Genes to Cells, 2019, in press
Effect of Modular Conjugation Strategy for N-Acetylgalactosamine-targeted Antisense Oligonucleotides
T. Yamamoto, M. Sawamura, C. Terada, K. Kashiwada, F. Wada, A. Yamayoshi, S. Obika, M. Harada-Shiba
Nucleosides, Nucleotides, Nucleic Acids, 2019, in press
Derivative Synthesis toward Enhancement of the Biophysical Properties of 2′,4′-Bridged Nucleic Acids
T. Yamaguchi, S. Obika
J. Synth. Org. Chem., 2019, 77, 994
Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties.
A. Fujii, O. Nakagawa, Y. Kishimoto, Y. Nakatsuji, N. Nozaki, S. Obika
ChemBioChem, 2019, in press
Synthesis of 2′-C,4′-C-Methyleneoxy-bridged Thymidine Derivatives and Properties of Modified Oligonucleotides
T. Osawa, H. Kim, M. Shoji, M. Saijo, M. Dohi, Y. Ito, S. Obika, Y. Hari
J. Org. Chem., 2019, 21, 13336
GREB1 Induced by Wnt Signaling Promotes Development of Hepatoblastoma by Suppressing TGFβ Signaling
S. Matsumoto, T. Yamamichi, K. Shinzawa, Y. Kasahara, S. Nojima, T. Kodama, S. Obika, T. Takehara, E. Morii, H. Okuyuama, A. Kikuchi
Nat. Commun., 2019, 10, 3882
Highly Efficient Silencing of microRNA by Heteroduplex Oligonucleotides
K. Yoshioka, T. Kunieda, Y. Asami, H. Guo, H. Miyata, K. Yoshida Tanaka, Y. Sujino, W. Piao, H. Kuwahara, K. Nishina, R. Hara, T. Nagata, S. Obika, T. Wada, T. Yokota
Nucleic Acids Res., 2019, 47, 7321
A Hydrogen Peroxide-activatable Gemcitabine Prodrug for The Selective Treatment of Pancreatic Ductal Adenocarcinoma
K. Matsushita, T. Okuda, S. Mori, M. Konno, H. Eguchi, A. Asai, J. Koseki, Y. Iwagami, D. Yamada, H. Akita, T. Asaoka, T. Noda, K. Kawamoto, K. Gotoh, S. Kobayashi, Y. Kasahara, K. Morihiro, T. Satoh, Y. Doki, M. Mori, H. Ishii, S. Obika
ChemMedChem, 2019, 14, 1384
Amido-bridged Nucleic Acid (AmNA)-modified Antisense Oligonucleotides Targeting α-Synuclein as A Novel Therapy for Parkinson’s Disease
T. Uehara, C.-J. Choong , M. Nakamori, H. Hayakawa, K. Nishiyama, Y. Kasahara, K. Baba, T. Nagata, T. Yokota, H. Tsuda, S. Obika, H. Mochizuki
Sci. Rep., 2019, 9, 7567
A Gapmer Antisense Oligonucleotide Targeting SRRM4 Is a Novel Therapeutic Medicine for Lung Cancer
M. Shimojo, Y. Kasahara, M. Inoue, S. Tsunoda, Y. Shudo, T. Kurata, S. Obika
Sci. Rep., 2019, 9, 7618
Enhancement of exon skipping activity by reduction in secondary structure content of LNA-based splice-switching oligonucleotides
T. Shimo, K. Tachibana, Y. Kawawaki, Y. Watahiki, T. Ishigaki, Y. Nakatsuji, T. Hara, J. Kawakami, S. Obika
Chem. Commun., 2019, 55, 6850-6853
Thymidine, 2-Thiothymidine, and 2-Selenothymidine: Comparison of Mismatch Discriminations
T. Habuchi, T. Yamaguchi, S. Obika
Heterocycles, 2019, 48, 832-837
1,3,9‐Triaza‐2‐Oxophenoxazine Artificial Nucleobase Forms Highly Stable Self‐base Pairs with Three AgI Ions in a Duplex
A. Fujii, O. Nakagawa, Y. Kishimoto, T. Okuda, Y. Nakatsuji, N. Nozaki, Y. Kasahara, S. Obika
Chem. Eur. J., 2019, 25, 7443-7448
Thioamide-bridged Nucleic Acid (thioAmNA) Bearing Thymine or 2-Thiothymine: Duplex Forming Ability, Base Discrimination, and Enzymatic Stability
T. Habuchi, T. Yamaguchi, S. Obika
ChemBioChem, 2019, 20, 1-9
Effective syntheses of 2’,4’-BNANC monomers bearing adenine, guanine, thymine, and 5-methylcytosine, and the properties of oligonucleotides fully modified with 2′,4′-BNANC
A. Fujisaka, Y. Hari, H. Takuma, S.M.A. Rahman, H. Yoshikawa, J. Pang, T. Imanishi, S. Obika
Bioorg. Med. Chem., 2019, 27, 1728–1741
Detection of Esterase Activity by Chromogenic and Fluorogenic Probe Based on an O-Nitrobenzoxadiazole (O-NBD) Unit
K. Okada, T. Yamaguchi, K. Dodo, M. Sodeoka, S. Obika
Bioorg. Med. Chem., 2019, 27, 1444–1448
Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
T. Harada, S. Matsumoto, S. Hirota, H. Kimura, S. Fujii, Y. Kasahara, H. Gon, T. Yoshida, T. Itoh, N. Haraguchi, T. Mizushima, T. Noda, H. Eguchi, S. Nojima, E. Morii, T. Fukumoto, S. Obika, A. Kikuchi
Mol. Cancer Ther., 2019, 18, 602
Hybridization and Mismatch Discrimination Abilities of 2′,4′-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase
T. Habuchi, T. Yamaguchi, H. Aoyama, M. Horiba, K. Ito, S. Obika
J. Org. Chem., 2019, 84, 1430-1439
High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors N3-Modified Thioflavin T Derivatives
Y. Kataoka, H. Fujita, A. Afanasyeva, C. Nagao, K. Mizuguchi, Y. Kasahara, S. Obika, M. Kuwahara
Biochemistry, 2019, 58, 493
■Reviews
Synthesis of Monovalent N‐Acetylgalactosamine Phosphoramidite for Liver‐Targeting Oligonucleotides
T. Yamamoto, C. Terada, K. Kashiwada, A. Yamayoshi, M. Harada-Shiba, S. Obika
Current Protocols in Nucleic Acid Chemistry, 2019, 78, e99
T. Yamamoto, C. Terada, K. Kashiwada, A. Yamayoshi, M. Harada-Shiba, S. Obika
Current Protocols in Nucleic Acid Chemistry, 2019, 78, e99
