Bioorganic Chemistry Channel,
Osaka University
→2017   →2016   →Back Number
2017
■Articles
Evaluation of size-exclusion chromatography for the analysis of phosphorothioate oligonucleotides.
Shimoyama A, Fujisaka A, Obika S.
J Pharm Biomed Anal. 2017 Mar 20;136:55-65.

Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle.
Hara T, Kodama T, Takegaki Y, Morihiro K, Ito KR, Obika S.
J Org Chem. 2017 Jan 6;82(1):25-36.

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.
Mitsuoka Y, Yamamoto T, Kugimiya A, Waki R, Wada F, Tahara S, Sawamura M, Noda M, Fujimura Y, Kato Y, Hari Y, Obika S.
J Org Chem. 2017 Jan 6;82(1):12-24.

■Reviews
Biological applications of xeno nucleic acids.
Morihiro K, Kasahara Y, Obika S.
Mol Biosyst. 2017 Jan 31;13(2):235-245.

■Books
2016
■Articles
SSystematic Evaluation of Biophysical and Functional Characteristics of Selenomethylene-Locked Nucleic Acid-Mediated Inhibition of miR-21.
Nahar S, Singh A, Morihiro K, Moai Y, Kodama T, Obika S, Maiti S.
Biochemistry. 2016 Dec 20;55(50):7023-7032.

In vitro and in vivo biophysical properties of oligonucleotides containing 5'-thio nucleosides.
Islam MA, Waki R, Fujisaka A, Ito KR, Obika S.
Drug Discov Ther. 2016;10(5):263-270.

Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.
Morihara H, Yamamoto T, Oiwa H, Tonegawa K, Tsuchiyama D, Kawakatsu I, Obana M, Maeda M, Mohri T, Obika S, Fujio Y, Nakayama H.
J Cardiovasc Pharmacol Ther. 2016 Nov 2. pii: 1074248416676392.

Synthesis of scpBNA-mC, -A, and -G Monomers and Evaluation of the Binding Affinities of scpBNA-Modified Oligonucleotides toward Complementary ssRNA and ssDNA.
Horiba M, Yamaguchi T, Obika S.
J Org Chem. 2016 Nov 18;81(22):11000-11008.

Synthesis and properties of novel 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyribonucleic acids with exocyclic methylene groups.
Osawa T, Obika S, Hari Y.
Org Biomol Chem. 2016 Oct 12;14(40):9481-9484.

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure.
Mitsuoka Y, Aoyama H, Kugimiya A, Fujimura Y, Yamamoto T, Waki R, Wada F, Tahara S, Sawamura M, Noda M, Hari Y, Obika S.
Org Biomol Chem. 2016 Jul 6;14(27):6531-8.

Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models.
Shinkai K, Nakano K, Cui L, Mizuuchi Y, Onishi H, Oda Y, Obika S, Tanaka M, Katano M.
Int J Cancer. 2016 Jul 15;139(2):433-45.

Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides.
Wada S, Yasuhara H, Wada F, Sawamura M, Waki R, Yamamoto T, Harada-Shiba M, Obika S.
J Control Release. 2016 Mar 28;226:57-65.

Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models.
Shinkai K, Nakano K, Cui L, Mizuuchi Y, Onishi H, Oda Y, Obika S, Tanaka M, Katano M.
Int J Cancer. 2016 Mar 3. doi: 10.1002/ijc.30075.

The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.
Kondo J, Nomura Y, Kitahara Y, Obika S, Torigoe H.
Chem Commun (Camb). 2016 Jan 28;52(11):2354-7.

Wavelength-selective light-triggered strand exchange reaction.
Morihiro K, Kodama T, Mori S, Tsunoda S, Obika S.
Org Biomol Chem. 2016 Jan 27;14(5):1555-8.

Consecutive incorporation of functionalized nucleotides with amphiphilic side chains by novel KOD polymerase mutant.
Hoshino H, Kasahara Y, Fujita H, Kuwahara M, Morihiro K, Tsunoda S, Obika S.
Bioorg Med Chem Lett. 2016 Jan 15;26(2):530-3.

Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.
Yamamoto T, Sawamura M, Wada F, Harada-Shiba M, Obika S.
Bioorg Med Chem. 2016 Jan 1;24(1):26-32.

■Reviews
Design of antisense oligonucleotides.
Obika S, Kasahara Y.
Nihon Yakurigaku Zasshi. 2016 Aug;148(2):100-4.

Synthesis and Properties of 2',4'-Bridged Nucleic Acids Containing Multiple Heteroatoms in the Bridges.
Hari Y, Obika S.
J. Syn. Org. Chem., Jpn., 2016 Mar 22, 74, 141-153.

Bioorganic Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University
1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
TEL:+81-6-6879-8200 FAX:+81-6-6879-8204
obika@phs.osaka-u.ac.jp