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Osaka University
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2017
■Articles
Synthesis and thermal stabilities of oligonucleotides containing 2’-O,4’-C-methylene bridged nucleic acid with a phenoxazine base
Y. Kishimoto, A. Fujii, O. Nakagawa, T. Nagata, T. Yokota, Y. Hari and S. Obika*
Org. Biomol. Chem. 2017;38(15):8145-52.

Small Nucleolar Noncoding RNA SNORA23, Upregulated in Human Pancreaic Ductal Adenocarcinoma, Regulates Expression of SYNE2 to Promote Growth and Metastasis of Xenograft Tumors in Mice.
L. Cui, K. Nakano, S. Obchoei, K. Setoguchi, M. Matsumoto, T. Yamamoto, S. Obika, K. Shimada, N. Hiraoka.
Gastroenterogy 2017 July;153:292-306.

Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonuclreotides including 2’-C, 4’-C-ethyleneoxy-bridged thymedine derivatives.
T. Osawa, M. Sawamura, F. Wada, T. Yamamoto, S. Obika, Y.Hari.
Org. Biomol. Chem. 2017 May;15(18):3955-63.

Synthesis of the 5-Methyluridine Monomer of 3’-O,4’-C-Ethyleneoxy-bridged Nucleic Acid.
T. Osawa, M. Dohi, Y. Hitomi, Y. Ito, S. Obika, Y. Hari.
J Heterocycles. 2017;95(1):342-52.

Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.
H. Morihara, T, Yamamoto, H. Oiwa, K. Tonegawa, D. Tsuchiyama, I. Kawakatsu, M. Obana, M. Maeda, T. Mohri, S. Obika, Y Fujio, H. Nakayama.
J. Cardiovasc. Pharmacol. Ther. 2017 May;22(3):273-82.

Evaluation of size-exclusion chromatography for the analysis of phosphorothioate oligonucleotides.
A. Shimoyama, A. Fujisaka, S. Obika.
J. Pharm. Biomed. Anal. 2017 Mar. 20;136:55-65.

Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle.
T. Hara, T. Kodama, Y. Takegaki, K. Morihiro, K.R. Ito, S. Obika.
J. Cardiovasc. Pharmacol. Ther. 2017 Jan. 6;82(1):25-36.

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.
Y. Mitsuoka, T. Yamamoto, A. Kugimiya, R. Waki, F. Wada, S. Tahara, M. Sawamura, M. Noda, Fujimura Y, Y. Kato, Y. Hari, S. Obika.
J Org. Chem. 2017 Jan. 6;82(1):12-24.

■Reviews
Biological applications of xeno nucleic acids.
K. Morihiro, Y. Kasahara, S. Obika.
Mol. Biosyst. 2017 Jan. 31;13(2):235-45.

■Books
2016
■Articles
Systematic Evaluation of Biophysical and Functional Characteristics of Selenomethylene-Locked Nucleic Acid-Mediated Inhibition of miR-21.
S. Nahar, A. Singh, K. Morihiro, Y. Moai, T. Kodama, S. Obika, S. Maiti.
Biochemistry. 2016 Dec. 20;55(50):7023-32.

In vitro and in vivo biophysical properties of oligonucleotides containing 5'-thio nucleosides.
M.A. Islam, R. Waki, A. Fujisaka, K.R. Ito, S. Obika.
Drug Discov. Ther. 2016;10(5):263-70.

Synthesis of scpBNA-mC, -A, and -G Monomers and Evaluation of the Binding Affinities of scpBNA-Modified Oligonucleotides toward Complementary ssRNA and ssDNA.
M. Horiba, T. Yamaguchi, S. Obika.
J Org. Chem. 2016 Nov. 18;81(22):11000-8.

Synthesis and properties of novel 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyribonucleic acids with exocyclic methylene groups.
T. Osawa, S. Obika, Y. Hari.
Org. Biomol. Chem. 2016 Oct. 12;14(40):9481-4.

Synthesis and Properties of 4-(Diarylmethylene)imidazolinone-conjugated Fluorescent Nucleic Acids
T. Okuda, S. Mori, Y. Kasahara, K. Morihiro, M. Ikejiri, K. Miyashita, S. Obika.
Tetrahedron Lett. 2016 July 20;57:3129-32.

Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models.
K. Shinkai, K. Nakano, L. Cui, Y. Mizuuchi, H. Onishi, Y. Oda, S. Obika, M. Tanaka, M. Katano.
Int. J. Cancer. 2016 July 15;139(2):433-45.

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure.
Y. Mitsuoka, H. Aoyama, A. Kugimiya, Y. Fujimura, T. Yamamoto, R. Waki, F. Wada, S. Tahara, M. Sawamura, M. Noda, Y. Hari, S. Obika.
Org. Biomol. Chem. 2016 July 6;14(27):6531-8.

Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides.
S. Wada, H. Yasuhara, F. Wada, M. Sawamura, R. Waki, T. Yamamoto, M. Harada-Shiba, S. Obika.
J. Control. Release. 2016 Mar. 28;226:57-65.

Crystal structure of a 2',4'-BNANC[N-Me]-modified antisense gapmer in complex with the target RNA.
J. Kondo, Y. Nomura, Y. Kitahara, S. Obika, H. Torigoe.
Chem. Commun. 2016 Jan. 28;52(11):2354-7.

Wavelength-selective light-triggered strand exchange reaction.
K. Morihiro, T. Kodama, S. Mori, S. Tsunoda, S. Obika.
Org. Biomol. Chem. 2016 Jan. 27;14(5):1555-8.

Consecutive incorporation of functionalized nucleotides with amphiphilic side chains by novel KOD polymerase mutant.
H. Hoshino, Y. Kasahara, H. Fujita, M. Kuwahara, K. Morihiro, S. Tsunoda, S. Obika.
Bioorg. Med. Chem. Lett. 2016 Jan. 15;26(2):530-3.

Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.
T. Yamamoto, M. Sawamura, F. Wada, M. Harada-Shiba, S. Obika.
Bioorg. Med. Chem. 2016 Jan. 1;24(1):26-32.

■Reviews
Design of antisense oligonucleotides.
S. Obika, Y. Kasahara.
Nihon Yakurigaku Zasshi. 2016 Aug;148(2):100-4.

Synthesis and Properties of 2',4'-Bridged Nucleic Acids Containing Multiple Heteroatoms in the Bridges.
Y. Hari, S. Obika.
J. Syn. Org. Chem., Jpn., 2016 Mar 22, 74, 141-153.

Bioorganic Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University
1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
TEL:+81-6-6879-8200 FAX:+81-6-6879-8204
obika@phs.osaka-u.ac.jp