次世代食品開発学(三井農林)共同研究講座

論文情報

学会発表

   

2020年3月28日

*日本薬学会第140年会@京都*

次世代機能性食品開発を目指したβ-カロテン非晶質固体分散体の作製とその評価

〇中川晋作


2020年3月25-28日

*日本薬学会第140年会@京都*

シンポジウム「中枢神経系疾患の未病克服および予防を目指した漢方薬・機能性食品成分のサイエンス」

~非晶質固体分散体技術によるナリンゲニンの水溶性向上と認知機能低下抑制作用~

〇吾郷由希夫、石本憲司、大谷修一、中川晋作


2019年9月24日

*日本油化学会第58回年会@東京*

機能性食品開発を目指したβカロテン固体分散体の作製とその評価

〇中川晋作


2019年7月4-5日

*第35会 日本DDS学会@横浜*

機能性食品を指向したナリンゲニン非晶質体の消化管吸収性に関する検討

〇島田有希子、石本憲司、大野茜、大谷修一、吾郷由希夫、中川晋作


2019年5月16日

*日本薬剤学会 第34年会 @富山*

β-カロテン非晶質固体分散体の体内動態解析

〇大谷修一、三木祥平、中村悠太、石本憲司、吾郷由希夫、中川晋作


2019年3月22日

*日本薬学会 第139年会 @千葉*

水への溶解性を向上させた非晶質化β-カロテンの消化管吸収特性評価

〇三木祥平、大谷修一、岩本泰樹、石本憲司、吾郷由希夫、中川晋作


2018年6月21日

*第34回 日本DDS学会 @長崎*

溶解性改善による有用性に優れた機能性食品を指向したナリンゲニン固体分散体の作製並びにその物性評価

〇大野茜、三木祥平、中村悠太、島田有希子、大谷修一、石本憲司、中村幹彦、中川晋作


2018年3月27日

*日本薬学会 第138年会 @金沢*

溶解改善による有用性に優れた機能性食品を指向した非晶質化β-カロテンの作製並びにその物性評価

〇三木祥平、大野茜、中村悠太、大谷修一、石本憲司、中村幹彦、中川晋作


論文

  1. Yoshida T, Oki H, Doi M, Fukuda S, Yuzuriha T, Tabata R, Ishimoto K, Kawahara K, Ohkubo T, Miyachi H, Doi T, Tachibana K.

    Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.

    Sci Rep, 10(1):7623, 2020.

  2. Otani S, Miki S, Nakamura Y, Ishimoto K, Ago Y, Nakagawa S.

    Improved bioavailability of β-carotene by amorphous solid dispersion technology in rats.

    J nutr sci vitaminol, 66(2):207-210, 2020.

  3. Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, Chen L, Kasai A, Seiriki K, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H, Ago Y.

    (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.

    Pharmacol Biochem Behav, 191:172876, 2020.

  4. Wu J, Wu H, Nakagawa S, Gao J.

    Virus-derived materials: bury the hatchet with old foes.

    Biomater Sci, 8(4):1058-1072, 2020.

  5. 石本 憲司, 中川 晋作.

    機能性食品開発を目指した非晶質固体分散技術の利用法 【総説】

    オレオサイエンス, 20(2):5-12, 2020.

  6. Ago Y, Tanabe W, Higuchi M, Tsukada S, Tanaka T, Yamaguchi T, Igarashi H, Yokoyama R, Seiriki K, Kasai A, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H.

    (R)-ketamine induces a greater increase in prefrontal 5-HT release than (S)-ketamine and ketamine metabolites via an AMPA receptor-independent mechanism.

    Int J Neouropsychopharmacol, 22(10):665-674, 2019.

  7. Miyachi H, Yuzuriha T, Tabata R, Fukuda S, Numomura K, Lin B, Kobayashi T, Ishimoto K, Doi T, Tachibana K.

    Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists.

    Bioorg Med chem Lett.,29(16):2124-2128, 2019.

  8. Ishimoto K, Miki S, Ohno A, Nakamura Y, Otani S, Nakamura M, Nakagawa S.

    β-Carotene solid dispersion prepared by hot-melt technology improves its solubilty in water .

    J Food Sci Technol. 56: 3540-3546, 2019.

  9. Tachibana K, Ishimoto K, Takahashi R, Kadono H, Awaji T, Yuzuriha T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Aoki S, Doi T.

    Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome.

    Chem Pharm Bull (Tokyo). 67(3): 199-202, 2019.

  10. Okuno H, Okuzono H, Hayase A, Kumagai F, Tanii S, Hino N, Okada Y, Tachibana K, Doi T, Ishimoto K.

    Lipin-1 is a novel substrate of protein phosphatase PGAM5.

    Biochem Biophys Res Commun. 509(4): 886-891, 2019.

  11. Shirakura K, Ishiba R, Kashio T, Funatsu R, Tanaka T, Fukada SI, Ishimoto K, Hino N, Kondoh M, Ago Y, Fujio Y, Yano K, Doi T, Aird WC, Okada Y.

    The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation.

    J Cell Sci. 132(1), 2019.

  12. Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T.

    Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.

    J Biol Chem. 293(26):10333-10343, 2018.

  13. Tanaka T, Izawa K, Maniwa Y, Okamura M, Okada A, Yamaguchi T, Shirakura K, Maekawa N, Matsui H, Ishimoto K, Hino N, Nakagawa O, Aird WC, Mizuguchi H, Kawabata K, Doi T, Okada Y.

    ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation.

    Sci Rep8(1): 5653, 2018.

  14. Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T.

    Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

    Biochem Biophys Res Commun. 488(1): 159-64, 2017.

  15. Tanaka T, Maekawa N, Kashio T, Izawa K, Ishiba R, Shirakura K, Ishimoto K, Hino N, Aird WC, Doi T, Okada Y.

    Tumor Necrosis Factor α Induces the Expression of the Endothelial Cell-Specific Receptor Roundabout4 through the Nuclear Factor-κB Pathway.

    Biol Pharm Bull.40(4): 504-9, 2017.

  16. Kita A, Hino N, Higashi S, Hirota K, Narumi R, Adachi J, Takafuji K, Ishimoto K, Okada Y, Sakamoto K, Tomonaga T, Takashima S, Mizuguchi H, Doi T.

    Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines.

    Sci Rep. 6: 36946, 2016.

  17. Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T.

    Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.

    PLoS One. 11(10): e0165766, 2016.

  18. Hirobe S, Otsuka R, Iioka H, Quan YS, Kamiyama F, Asada H, Okada N, Nakagawa S

    Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo.

    Life Sci., 168:24-27, 2017.

  19. Wan L, Yao X, Faiola F, Liu B, Zhang T, Tabata Y, Mizuguchi H, Nakagawa S, Gao JQ, Zhao RC

    Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells.

    Int. J Nanomedicine., 11:6763-6769, 2016.

  20. Matsuo K, Hirobe S, Okada N, Nakagawa S

    Analysis of skin permeability and toxicological properties of amorphous silica particles.

    Biol. Pharm. Bull., 39(7):1201-5, 2016.

  21. Kamei K, Kawabata H, Asakura M, Samosornsuk W, Hienoya A, Nakagawa S, Yamasaki S.

    Cytolethal distending toxin gene-based multiplex PCR assay for Campylobacter jejuni, C. coli, C. fetus, C. upsaliensis, C. hyointestinalis and C. lari.

    Jpn J Infect Dis., 69, 256-258, 2016.

  22. Kamei K, Hatanaka N, Asakura M, Somroop S, Samosornsuk W, Hinenoya A, Misawa N, Nakagawa S, Yamasaki S.

    Campylobacter hyointestinalis Isolated from Pigs Produces Multiple Variants of Biologically Active Cytolethal Distending Toxin.

    Infect Immun., 83(11), 4304-13, 2015.

  23. Nagano K, Imai S, Zhao X, Yamashita T, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Nakagawa S, Tsutsumi Y, Tsunoda S.

    Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors.

    Int J Oncol., 47(1):195-203, 2015.

  24. Hirobe S, Azukizawa H, Hanafusa T, Matsuo K, Quan YS, Kamiyama F, Katayama I, Okada N, Nakagawa S.

    Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch.

    Biomaterials., 57:50-8, 2015.

  25. Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, García-Cardeña G, Aird WC, Doi T.

    Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter.

    Arterioscler Thromb Vasc Biol., 34(7):1531-8, 2014.

  26. Yao X, Zhou N, Wan L, Su X, Sun Z, Mizuguchi H, Yoshioka Y, Nakagawa S, Zhao RC, Gao JQ.

    Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells.

    Biochem Biophys Res Commun., 9;447(3):383-7, 2014.

  27. Kamei K, Asakura M, Somroop S, Hatanaka N, Hinenoya A, Nagita A, Misawa N, Matsuda M, Nakagawa S, Yamasaki S.

    A PCR-RFLP assay for the detection and differentiation of Campylobacter jejuni, C. coli, C. fetus, C. hyointestinalis, C. lari, C. helveticus and C. upsaliensis.

    J Med Microbiol., 63(Pt 5):659-66, 2014.

次世代食品開発学(三井農林)
共同研究室講座

〒565-0871
大阪府吹田市山田丘1-6薬学研究科3号館2階211号室

06-6879-8178

06-6879-8179