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NEWS&FAQ

研究業績

      ●2016年
  ●2015年
  ●2014年
  ●2013年
  ●2012年
  
●2011年
  ●2010年
  ●2009年
  ●2008年
  ●2007年
  ●2006年




2016年

[1] 
Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-
     reactive monoclonal antibody.
     Y.Hashimoto, Y.Kawahigashi, T.Hata, X.Li, A.Watari, M.Tada, A.ishii-Watabe, Y.Okada, T.Doi, M.Fukasawa
     H.Kuniyasu, K.Yagi, M.Kondoh
     Pharmacol Res Perspect. 2016 Sep 27;4(5):e00266.
[2] Roles of the first-generation claudin binder, Clostridium perfringens enterotoxin, in the diagnosis and      claudin-targeted treatment of epithelium-derived cancers.
    
Y.Hashimoto, K.Yagi, M.Kondoh
     Pflugers Arch. 2016 Sep 15. [Epub ahead of print] Review.

[3] Current progress in a asecond-generation claudin binder, anti-claudin antibody, for clinical applications.
     Y.Hashimotok K.Yagi, M.Kondoh
     Drug Discov Today. 2016 Jul 12,pii:S1359-6446(16) 30254-9
[4] Generation and characterization of a human-mouse chimeric antibody againt the extracellular domain of      claudin-1 for cancer therapy using a mouse model.
     Y.Hashimoto, M.Tada, M.Iida, S.Nagase, T.Hata, A.Watari, Y.Okada, T.Doi, M.Fukasawa, K.Yagi, M.Kondoh
     Biochem Biophys Res Commun. 2016 Aug 12;477(1): 91-5
[5] Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus      Infection.

    
Y.Shirasago, Y.Shimizu, I.Tanida, T.Suzuki, R.Suzuki, K.sugiyama, T.Wakita, K.Hanada, K.Yagi, M.Kondoh,      M.Fukasawa
     Bio Pharm Bull. 2016 May 1;39 (5): 839-48
[6] Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5      Expression.
     A. Watari, M.Hasegawa, K.Yagi, M.Kondoh
     PLoS One. 2016 Jan 4;11 (1): e0145631

                                                   

●2015年 
[1] Claudin-1 Binder Enhances Epidermal Permeablity in a Human Keratinocyte Model.
     M.Nakajima, S.Nagase, M.Iida, S.Tkeda, M.Yamashita, A.Watari, Y.Sihrasago, M.Fukasawa, H.Takeda,      T.Sawasaki, K.Yagi, M.Kondoh

     J Pharmacol Exp Ther. 2015 Sep;354 (3): 440-7
[2] C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine.
     H.Suzuki, A.Watari, E.Hashimoto, M.Yonemitsu, H.Kiyono, K.Yagi, M.Kondoh, J.Kunisawa.
     PLoS One. 2015 May 27;10 (5): e0126352
[3] Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin.
     K.Matsuhia, S.Yamane, T.Okamoto, A.Watari, M.Kondoh, Y.Matsuura, K.Yagi.
     Biochem Biophys Res Commun. 2015 Jun 19;462 (1); 52-7
[4] Use of cell-based screening to identify small-molecule compounds that modulate claudin-4 expression.
     A.Watari, M.Hasegawa, T.Muangman, K.Yagi, M.Kondoh.
     Biotechnol Lett. 2015 Jun;37 (6); 1177-85
[5] Monoclonal antibodies against extracellular domains of claudin-1 block hepatitis C virus infection in a mouse      model.
     M.Fukasawa, S.Nagase, Y.Shirasago, M.Iida, M.Yamashita, K.Endo, K.Yagi, T.Suzuki, T.Wakita, K.Hanada,      H.Kuniyasu, M.Kondoh.
     J Virol. 2015 May;89(9); 4866-79
[6] Discovery of anti-claudin-1 antibodies as candidate therapeutics against hepariris C virus.
     M.Yamashit, M.Iida, M.Tada, Y.Shirasago, M.Fukasawa, S.Nagase, A.Watari, A.Ishii-Watabe, K.Yagi, M.Kondoh
     J Pharmacol Exp Ther. 2015 Apr;353(1); 112-8
[7] Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in
      Caco-2  cell monolayers.
     A.Watari, M.Hasegawa, K.Yagi, M.Kondoh
     Eur J Pharm Biopharm. 2015 Jan;89;232-8


2014年
[1] Development of an anti-claudin-3 and -4 bispecific monoclonal antibody for cancer diagnosis and therapy.
     X.Li, M.Iida, M.Tada, A.Watari, Y.Kawahigashi, Y.Kimura, T.Yamashita, A Ishii-Watabe,T.Uno, M.Fukasawa,      H.Kuniyasu, K.Yagi, M.Kondoh
     J Pharmacol Exp Ther. 2014 Oct;351(1);206-13
[2] [The new era of epithelium-targeted drug development.]
     Y.Shimizu, S.Nagase, K.Yagi, M.Kondoh
     YakugakuZasshi. 2014;134(5);641-5
[3] [The development of mucosal vaccine using bacterial function for targeting mucosal tissues.]
     H.Suzuki, M.Kondoh, K.Yagi, J.Kunisawa
     YakugakuZasshi. 2014;134(5);629-34
[4] Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of      Clostridium perfringens enterotoxin.
     X.Li, R.Saeki, A.Watari, K.Yagi, M.Kondoh
     Eur J Pharm Sci. 2014 Feb 14;52;132-7



●2013年
[1] A baculoviral display system to assay viral entry.
     M.Iida, T.Yoshida, A.Watari, K.Yagi, T.Hamakubo, M.Kondoh
     Bio Pharm Bull. 2013;36(11):1867-9
[2] Acute and chronic nephrotoxicity of platinum nanoparticles in mice.
     Y.Yamagishi, A.Watari, Y.Hayata, X.Li, M.Kondoh, Y.Yoshioka, Y.Tsutsumi, K.Yagi
     Nanoscale Res Lett. 2013 Sep 23;8(1):395
[3] Recent advances in claudin-targeting technology.
     S.Nagase, R.Doyama, K.Yagi, M.Kondoh
     Bio Pharm Bull. 2013;36(5):708-14
[4] Hepatotoxicity of sub-nanosized platinum particles in mice.
     Y.Yamagishi, A.Watari, Y.Hayata, X.Li, M.Kondoh, Y.Tsutsumi, K.Yagi
     Pharmazie. 2013 Mar;68(3):178-82
[5]
 [Development of an adenovirus vector containing a hepatitis C virus expression cassette and its application.]
     T.Yoshida, M.Kondoh, H.Mizuguchi, K.Yagi
     Yakugaku Zasshi. 2013;133(3):305-11
[6] Precolation analysis in electrical conductivity of Madin-Darby canine kidney and Caco-2 cells by
     permeation-enhancing agents.
     M.Washiyama, N.Koizumi, M.Fujii, M.Kondoh, K.Yagi, Y.Watanabe

    
Bio Pharm Bull.2013;36(3):384-9


●2012年
[1] A simple reporter assay for screening claudin-4 modulators.
     A.Watari, K.Yagi, M.Kondoh
     Biochem Biophys Res Commun. 2012 Oct 5;426(4):454-60
[2] Proof of concept for clauin-targeted drug development.
     H.Suzuki, M.Kondoh, A.Takahahi, K.Yagi
     Ann N Y Acad Sci. 2012 Jul;1258:65-70
[3] Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific      claudin binder.
     K.Matushisa, M.Kondoh, H.Suzuki, K.Yagi
     Biochem Biophys Res Commun. 2012 Jun 29;423(2):229-33
[4] Pathological changes in tight junctions and potential applications into therapies.
     A.Takahashi, M.Kondoh, H.Suzuki, A.Watari, K.Yagi
     Drug discov Today. 2012 Jul;17(13-14):727-32
[5] Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against
     miR-122a.
     F.Sakurai, N.Furukawa, M.Higuchi, S.Okamoto, K.Ono,T.Yoshida, M.Kondoh, K.Yagi, N.Sakamoto, K.Katayama,      H.Mizuguchi
     Virus Res. 2012 May;165(2):214-8
[6] Creation and biochemical analysis of a broad-specific claudin binder.
     A.Takahashi, Y.Saito, M.Kondoh, K.Matsushita, SM Krug, H.Suzuki, H.Tsujino, X.Li, H.Aoyama, K.Matsuhisa,      T.Uno, M.Fromm, T.Hamakubo, K.Yagi
     Biomaterials. 2012 Apr;33(12):3464-74
[7] Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure.
     H.Nabeshi, T.Yoshikawa, K.Matsuyama, Y.Nakazato, A.Arimori, M.Isobe, S.Tochigi, S.Kondoh, T.Hirai, T.Akase,      T.Yamashita, K.Yamashita, T.Yoshida, K.Nagano, Y.Abe, Y.Yoshioka, H.Kamada, T.Imazawa, N.Itoh,      M.Kondoh, K.Yagi, T.Mayumi, S.Tsunoda, Y.Tutsumi
     Nanotechnology. 2012 Feb 3;23(4):045101
[8] The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens      enterotoxin as a mucosal vaccine in mice.
     H.Suzuki, M.Kondoh, H.Kakutani, S.Ymane, H.Uchida, T.Hamamoto, K.Yagi
     Biomaterials. 2012 Jan;33(1):317-24
[9] Spiral progression in the development of absorption enhancers based on the biology of tight junctions.
     M.Kondoh, A.Takahashi, K.Yagi
     Adv Drug Deliv Rev. 2012 May 1;64(6):515-22



●2011年

[1] T. Yoshida, K. Takayama, M. Kondoh, F. Sakurai, H. Tani, N. Sakamoto, Y. Matsuura, H. Mizuguchi, K. Yagi, Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection, Biochem Biophys Res Commun, in press.
[2] 近藤昌夫、八木清仁、Claudin modulatorを用いた難吸収性薬物の消化管・経粘膜デリバリー、難吸収性薬物の吸収改善と新規投与製剤の開発、株式会社シーエムシー出版
[3] 近藤昌夫、八木清仁、タイトジャンクションを標的とした創薬研究の螺旋的発展、ファルマシア
[4] H. Suzuki, M. Kondoh, H. Kakutani, S. Yamane, H. Uchida, T. Hamakubo, K. Yagi, The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice, Biomaterials . 
[5] A. Takahashi, M. Kondoh, K. Yagi, A non-invasive drug delivery system using claudin binder, Yakugakuzasshi, 131 (2011) 1583-1587.
[6] A. Takahashi, M. Kondoh, H. Uchida, Y. Kakamu, T. Hamakubo, K. Yagi, Mutated C-terminal fragments of Clostridium perfringens enterotoxin have increased affinity to claudin-4 and reversibly modulate tight junctions in vitro, Biochem Biophys Res Commun, 410 (2011) 466-470.
[7] T. Suzuki, T. Sasaki, K. Yano, F. Sakurai, K. Kawabata, M. Kondoh, K. Yagi, H. Mizuguchi, Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome, Virus Res 158 (2011) 154-160.
[8] T. Hasezaki, K. Isoda, M. Kondoh, Y. Tsutsumi, K. Yagi, Hepatotoxicity of silica nanoparticles with a diameter of 100 nm, Pharmazie, 66 (2011) 698-703.
[9] T. Yoshida, M. Kondoh, M. Ojima, H. Mizuguchi, Y. Yamagishi, N. Sakamoto, K. Yagi, Adenovirus vector-mediated assay system for Hepatitis C virus replication, Nucleic Acid Res 6  (2011)  e16611.
[10] A. Takahashi M. Kondoh, M. Kodaka, K. Yagi, Peptides as tight junction modulators, Curr Pharm Design (in press).
[11] 小高美樹、近藤昌夫、八木清仁、Claudin modulatorを用いたペプチド・タンパク質医薬品の経粘膜吸収促進、遺伝子医学MOOK (2011) 64-69.
[12] H. Suzuki, M. Kondoh, A. Takahashi, K. Matsuhisa, K. Matsushita, Y. Kakamu, S. Yamane, M. Kodaka, K. Yagi, A toxicological evaluation of a claudin modulator, C-terminal fragment of Clostridium perfringens enterotoxin, in mice, Pharmazie 66 (2011) 543-546.
[13] K. Isoda, T. Hasezaki, M. Kondoh, Y. Tsutsumi, K. Yagi, Effect of surface charge on nano-sized silica particles-induced liver injury, Pharmazie 66 (2011) 278-281.
[14] X. Li, M. Kondoh, A. Watari, T. Hasezaki, K. Isoda, Y. Tsutsumi, K. Yagi, Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice, Pharmazie 66 (2011) 282-286.
[15] H. Kakutani, A. Takahashi, M. Kondoh, Y. Saito, T. Yamaura, T. Sakihama, T. Hamakubo, K. Yagi, A novel screening system for claudin binder using baculoviral display, PLoS ONE 6 (2011) e16611.
[16] T. Yoshida, M. Kondoh, K. Yagi, Promosing targets for anti-hepatitis C virus agents, Curr Med Chem 18 (2011) 1239-1244.
[17] A. Takahashi, M. Kondoh, H. Suzuki, K. Yagi, Claudin as a targetfor drug development, Curr Med Chem 18 (2011) 1861-1865.


●2010

[1] H. Suzuki, H. Kakutani, M. Kondoh, A. Watari, K. Yagi, The safety of a mucosal vaccine using the C-terminal fragment of Clostridum perfringens enterotoxin, Pharmazie 10 (2010) 766-769.
[2] R. Saeki, M. Kondoh, H. Kakutani, K. Matsuhisa, A. Takahashi, H.Suzuki, Y. Kakamu, A. Watari, K. Yagi, A claudin-targeting molecule as an inhibitor of tumor metastasis, J Pharmacol Exp Ther 334 (2010) 576-582.
[3] A. Watari, N. Iwabe, H. Masuda, M. Okada, Functional transition of Pak proto-oncogene during early evolution of metazoans, Oncogene 29 (2010) 3815-3826.
[4] K. Yagi, M. Kawase, K. Isoda, M. Kondoh, [Development of novelculture system for regulation of hepatocyte function], Yakugaku Zasshi 130(2010) 537-543.
[5] M. Ushitora, F. Sakurai, T. Yamaguchi, S. Nakamura, M. Kondoh,K. Yagi, K. Kawabata, H. Mizuguchi, Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors, J Control Release 142 (2010) 431-437.
[6] H. Uchida, M. Kondoh, T. Hanada, A. Takahashi, T. Hamakubo, K.Yagi, A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide, Biochem Pharmacol 79 (2010) 1437-1444.
[7] H. Kakutani, M. Kondoh, R. Saeki, M. Fujii, Y. Watanabe, H.Mizuguchi, K. Yagi, Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin, Eur J Pharm Biopharm 75 (2010) 213-217.
[8] H. Kakutani, M. Kondoh, M. Fukasaka, H. Suzuki, T. Hamakubo, K.Yagi, Mucosal vaccination using claudin-4-targeting, Biomaterials 31 (2010)5463-5471.
[9] A. Itoh, K. Isoda, M. Kondoh, M. Kawase, A. Watari, M.Kobayashi, M. Tamesada, K. Yagi, Hepatoprotective effect of Syringic Acid and Vanillic Acid on CCl(4)-Induced Liver Injury, Biol Pharm Bull 33 (2010) 983-987.
[10] R. Saeki, M. Kondoh, H. Uchida, K. Yagi, Potency of claudin-targeting as antitumor therapy, Mol Cell Pharmacol 2 (2010) 47-50.
[11] M. Sato, T. Kawakami, M. Kondoh, M. Takiguchi, Y. Kadota, S. Suzuki, Development of high-fat-diet-induced obesity in female metallothionein-null mice, FASEB J 24 (2010) 2375-2384.


●2009年

[1] H. Nishimori, M. Kondoh, K. Isoda, S. Tsunoda, Y. Tsutsumi, K.Yagi, Silica nanoparticles as hepatotoxicants, Eur J Pharm Biopharm 72 (2009)496-501.
[2] H. Nishimori, M. Kondoh, K. Isoda, S. Tsunoda, Y. Tsutsumi, K.Yagi, Histological analysis of 70-nm silica particles-induced chronic toxicityin mice, Eur J Pharm Biopharm 72 (2009) 626-629.
[3] K. Matsuhisa, M. Kondoh, A. Takahashi, K. Yagi, Tight junction modulator and drug delivery, Expert Opin Drug Deliv 6 (2009) 509-515.
[4] A. Itoh, K. Isoda, M. Kondoh, M. Kawase, M. Kobayashi, M.Tamesada, K. Yagi, Hepatoprotective effect of syringic acid and vanillic acidon concanavalin a-induced liver injury, Biol Pharm Bull 32 (2009) 1215-1219.
[5] H. Nishimori, M. Kondoh, K. Isoda, S. Tsunoda, Y. Tsutsumi, K.Yagi, Influence of 70 nm silica particles in mice with cisplatin or paraquat-induced toxicity, Pharmazie 64 (2009) 395-397.
[6] R. Saeki, M. Kondoh, H. Kakutani, S. Tsunoda, Y. Mochizuki, T.Hamakubo, Y. Tsutsumi, Y. Horiguchi, K. Yagi, A novel tumor-targeted therapyusing a claudin-4-targeting molecule, Mol Pharmacol 76 (2009) 918-926.
[7] M.H. Kim, M. Kino-oka, Y. Morinaga, Y. Sawada, M. Kawase, K.Yagi, M. Taya, Morphological regulation and aggregate formation of rabbit chondrocytes on dendrimer-immobilized surfaces with D-glucose display, J Biosci Bioeng 107 (2009) 196-205.
[8] M. Kondoh, A. Takahashi, R. Saeki, K. Yagi, Claudin binder as anovel drug delivery system, Drug Delivery System 24 (2009) 532-537.



●2008年


[1] S. Hayashi, A. Itoh, K. Isoda, M. Kondoh, M. Kawase, K. Yagi, Fucoidan partly prevents CCl4-induced liver fibrosis, Eur J Pharmacol 580(2008) 380-384.
[2] E. Ikeda, K. Yagi, M. Kojima, T. Yagyuu, A. Ohshima, S.Sobajima, M. Tadokoro, Y. Katsube, K. Isoda, M. Kondoh, M. Kawase, M.J. Go, H.Adachi, Y. Yokota, T. Kirita, H. Ohgushi, Multipotent cells from the humanthird molar: feasibility of cell-based therapy for liver disease, Differentiation 76 (2008) 495-505.
[3] K. Isoda, N. Kagaya, S. Akamatsu, S. Hayashi, M. Tamesada, A.Watanabe, M. Kobayashi, Y. Tagawa, M. Kondoh, M. Kawase, K. Yagi, Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury, Biol Pharm Bull 31 (2008) 309-311.
[4] M. Kondoh, T. Yoshida, H. Kakutani, K. Yagi, Targeting tight junction proteins-significance for drug development, Drug Discov Today 13(2008) 180-186.
[5] A. Takahashi, E. Komiya, H. Kakutani, T. Yoshida, M. Fujii, Y.Horiguchi, H. Mizuguchi, Y. Tsutsumi, S. Tsunoda, N. Koizumi, K. Isoda, K.Yagi, Y. Watanabe, M. Kondoh, Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis, Biochem Pharmacol 75 (2008) 1639-1648.
[6] E. Arita, M. Kondoh, K. Isoda, H. Nishimori, T. Yoshida, H.Mizuguchi, K. Yagi, Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors, Eur J Pharm Biopharm 70 (2008) 1-6.
[7] T. Suzuki, F. Sakurai, S. Nakamura, E. Kouyama, K. Kawabata, M.Kondoh, K. Yagi, H. Mizuguchi, miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide genetherapy, Mol Ther 16 (2008) 1719-1726.
[8] K. Yagi, M. Kojima, S. Oyagi, E. Ikeda, M. Hirose, K. Isoda, M.Kawase, M. Kondoh, H. Ohgushi, Application of mesenchymal stem cells to liver regenerative medicine, Yakugaku Zasshi 128 (2008) 3-9.
[9] M.H. Kim, M. Kino-Oka, M. Kawase, K. Yagi, M. Taya, Glucose transporter mediation responsible for morphological changes of human epithelial cells on glucose-displayed surfaces, J Biosci Bioeng 105 (2008) 319-326.
[10] K. Yoshida, K. Inoue, Y. Takahashi, S. Ueda, K. Isoda, K. Yagi,I. Maeda, Novel carotenoid-based biosensor for simple visual detection of arsenite: characterization and preliminary evaluation for environmental application, Appl Environ Microbiol 74 (2008) 6730-6738.


●2007年

[1] M. Kondoh, K. Yagi, Progress in absorption enhancers based ontight junction, Expert Opin Drug Deliv 4 (2007) 275-286.
[2] M. Kondoh, K. Yagi, Tight junction modulators: promisingcandidates for drug delivery, Curr Med Chem 14 (2007) 2482-2488.
[3] M. Kondoh, K. Yagi, The claudin family as a new approach for drug delivery, Drugs Fut. 32 (2007) 1053-1059.
[4]八木清仁,磯田勝広,近藤昌夫,チオレドキシン(TRX), Surgery Frontier 14 (2007) 79-81.
[5]近藤昌夫,組織を囲む仕組み,生物工学会誌 85 (2007) 20.
[6] M. Harada, M. Kondoh, C. Ebihara, A. Takahashi, E. Komiya, M.Fujii, H. Mizuguchi, S. Tsunoda, Y. Horiguchi, K. Yagi, Y. Watanabe, Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin, Biochem Pharmacol 73 (2007) 206-214.
[7] M. Harada, M. Kondoh, A. Masuyama, M. Fujii, T. Nakanishi, N.Utoguchi, K. Yagi, Y. Watanabe, Effect of forskolin on the expression ofclaudin-5 in human trophoblast BeWo cells, Pharmazie 62 (2007) 291-294.
[8] C. Ebihara, M. Kondoh, M. Harada, M. Fujii, H. Mizuguchi, S.Tsunoda, Y. Horiguchi, K. Yagi, Y. Watanabe, Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction, Biochem Pharmacol 73 (2007) 824-830.
[9] M. Kondoh, M. Fujii, K. Yagi, Y. Watanabe, [Barriology-based strategy for drug absorption], Yakugaku Zasshi 127 (2007) 601-609.
[10] M. Kino-oka, Y. Morinaga, M.H. Kim, Y. Takezawa, M. Kawase, K.Yagi, M. Taya, Morphological regulation of rabbit chondrocytes onglucose-displayed surface, Biomaterials 28 (2007) 1680-1688.
[11] M.H. Kim, M. Kino-Oka, M. Kawase, K. Yagi, M. Taya, Synergistic effect of D-glucose and epidermal growth factor display on dynamic behaviors of human epithelial cells, J Biosci Bioeng 104 (2007) 428-431.
[12] M.H. Kim, M.Kino-Oka, M. Kawase, K. Yagi, M. Taya, Response of human epithelial cells toculture surfaces with varied roughnesses prepared by immobilizing dendrimers with/without D-glucose display, J Biosci Bioeng 103 (2007) 192-199.
[13] Y. Ohba, Y. Kanao, N. Morita, E. Fujii, H. Hohrai, H. Hirose, D. Miura, A. Watari, M. Yutsudo, H. Zhao, N. Yabuta, A. Ito, Y. Kita, N. Nojima, Oleamide derivatives suppression the sponteneous metastasis by inhibiting connexin 26, Int J Cancer 121 (2007) 47-54.


2006年


[1] Y. Nakatake, N. Fukui, Y. Iwamatsu, S. Masui, K. Takahashi, R.Yagi, K. Yagi, J. Miyazaki, R. Matoba, M. S. Ko, and H. Niwa, Klf4 cooperateswith Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells, Mol. Cell. Biol., 26 (2006) 7772-7782.
[2] S. Oyagi, M. Hirose, M. Kojima, M. Okuyama, M. Kawase, T.Nakamura, H. Ohgushi, and K. Yagi, Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats, J. Hepatol.,44 (2006) 742-748.
[3] K. Isoda, E. Arita, M. Kojima, M. Ikkaku, F. Tashiro, E. Yamato,J. Miyazaki, M. Kawase, M. Kondoh, and K. Yagi, Protection against CCl4-inducedinjury in liver by adenovirally introduced thioredoxin gene, Biochem. Biophys.Res. Commun.,350 (2006) 157-161.
[4] I. Maeda, Y. Seto, S. Ueda, Y. Chen, J. Hari, M. Kawase, H.Miyasaka, and K. Yagi, Simultaneous control of turbidity and dilution rate through adjustment of medium composition in semi-continuous Chlamydomonas cultures, Biotechnol. Bioeng. 94 (2006) 722-729.
[5] H. Fujimoto, M. Wakabayashi, H. Yamashiro, I. Maeda, K. Isoda,M. Kondoh, M. Kawase, H. Miyasaka, and K. Yagi, Whole-cell arsenite biosensor using photosynthetic bacterium Rhodovulum sulfidophilum, Appl. Microbiol.Biotechnol. 73 (2006) 332-338.
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大阪大学大学院薬学研究科
生体機能分子化学分野

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