業績 (2001-2013)   





【2013年】【2012年】【2011年】【2010年】【2009年】【2008年】【2007年】

【2006年】
【2005年】
【2004年】【2003年】【2002年】【2001年】




 ★ 2013年 ★




1. Ryota Araki, Yukio Ago, Shigeru Hasebe, Saki Nishiyama, Tatsunori Tanaka, Satoshi Oka,
  Kazuhiro Takuma, Toshio Matsuda:
  Involvement of prefrontal AMPA receptors in encounter stimulation-induced hyperactivity in
  isolation-reared mice.   
  Int. J. Neuropsychopharmaco., in press.


2. Toshio Matsuda:
  Neuropharmacological studies on brain 5-HT1A receptor using the selective agonist osemozotan.  
  Biol. Pharm. Bull
., 36(12):1871-82, 2013.


3. Naotaka Horiguchi, Yukio Ago, Shigeru Hasebe, Kosuke Higashino, Kazuki Asada, Yuki Kita,
  Kazuhiro Takuma, Toshio Matsuda:
  Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain.
  model of attention-deficit/hyperactivity disorder, via α2-adrenoceptor activation.
  Pharmacol. Biochem. Behav., 113: 46-52, 2013.


4. Naoki Hiramatsua, Yukio Ago, Shigeru Hasebe, Akira Nishimura, Kazuya Mori, Kazuhiro Takuma,
  Toshio Matsuda:
  Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission
  under circulating steroid deficiency.
  Neuropharmacology, 75: 53-61, 2013.


5. Yukio Ago, Ryota Araki, Tatsunori Tanaka, Asuka Sasaga, Saki Nishiyama, Kazuhiro Takuma,
  Toshio Matsuda:
  Role of social encounter-induced activation of prefrontal serotonergic systems in the abnormal
  behaviors of isolation-reared mice.
  Neuropsychopharmacology, 38 (8): 1535-1547, 2013.


6. Masato Umehara, Yukio Ago, Takuya Kawanai, Kazumi Fujita, Naoki Hiramatsu, Kazuhiro Takuma,
  Toshio Matsuda:
  Methylphenidate and venlafaxine attenuate locomotion in spontaneously hypertensive rats, an animal
  model of attention-deficit/hyperactivity disorder, via α2-adrenoceptor activation.
  Behav. Pharmacol., 24 (4): 328-331, 2013.


7. Naotaka Horiguchi, Yukio Ago, Kazuki Asada, Yuki Kita, Naoki Hiramatsu, Kazuhiro Takuma,
  Toshio Matsuda:
  Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice.
  Psychopharmacology (Berl), 227 (2): 251-261, 2013.


8. Masato Umehara, Yukio Ago, Kazumi Fujita, Naoki Hiramatsu, Kazuhiro Takuma,
  Toshio Matsuda:
  Effects of serotonin–norepinephrine reuptake inhibitors on locomotion and prefrontal
  monoamine release in spontaneously hypertensive rats.
  Eur. J. Pharmacol., 702 (1-3): 250-257, 2013.


9. Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura, Yukio Ago, Kazuhiro Takuma,
  Toshio Matsuda:
  Effect of overexpression of the brain-specific Na+/Ca2+ exchanger splice variant NCX1.5 on NO
  cytotoxicity in HEK293 cells.
  J. Pharmacol. Sci., 121 (4): 351-354, 2013.


10. Kazuhiro Takuma, Yukio Ago, Toshio Matsuda:
  The glial sodium-calcium exchanger: a new target for nitric oxide-mediated cellular toxicity.
  Curr. Protein Pept. Sci., 14 (1): 43-50, 2013. 


11. Yuki Kita, Yukio Ago, Erika Takano, Asako Fukada, Kazuhiro Takuma, Toshio Matsuda:
  Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic
  acetylcholine receptors in mice.

  Psychopharmacology (Berl), 225 (3): 543-551, 2013.  


12. Yukio Ago, Koji Yano, Ryota Araki, Naoki Hiramatsu, Yuki Kita, Toshiyuki Kawasaki,
  Hirotaka Onoe, Shigeyuki Chaki, Atsuro Nakazato, Hitoshi Hashimoto, Akemichi Baba,
  Kazuhiro Takuma, Toshio Matsuda:
  Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal
  dopaminergic alterations in the chronic corticosterone-induced depression model in mice.     
  Neuropharmacology, 65: 29-38, 2013.



13. Yukio Ago, Naoki Hiramatsu, Toshihiro Ishihama, Keisuke Hazama, Atsuko Hayata-Takano,
  Yasuhiro Shibasaki, Norihito Shintani, Hitoshi Hashimoto, Toshiyuki Kawasaki, Hirotaka Onoe,
  Shigeyuki Chaki, Atsuro Nakazato, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda:

  The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor
  abnormalities and recognition memory deficits in mice lacking the pituitary adenylate
  cyclase-activating polypeptide.

  Behav. Pharmacol., 24 (1): 74-77, 2013.


14. Shunsuke Kataoka, Kazuhiro Takuma, Yuta Hara, Yuko Maeda, Yukio Ago, Toshio Matsuda:
  Autism-like behaviors with transient histone hyperacetylation in mice treated prenatally with
  valproic acid.
  Int. J. Neuropsychopharmacol., 16 (1): 91-103, 2013.


15. Shigeyuki Chaki, Yukio Ago, Agnieszka Palucha-Paniewiera, Francesco Matrisciano,
  Andrzej Pilc:
  mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants.
  Neuropharmacology, 66: 40-52, 2013.


16. Yejie Shi, Hui Yuan, Dong Kim, Vishal Chanana, Akemichi Baba, Toshio Matsuda, Pelin Cengiz,
  Peter Ferrazzano, Dandan Sun:
  Stimulation of Na+/H+ exchanger isoform 1 promotes microglial migration.
  PLoS One, 8 (8): e74201, 2013.


17. Chung-Chuan Chou, Po-Cheng Chang, Ming-Shien Wen, Hui-Ling Lee, Yen Chu, Akemichi Baba,
  Toshio Matsuda, San-Jou Yeh, Delon Wu:
  Effects of SEA0400 on Arrhythmogenicity in a Langendorff-Perfused 1-Month Myocardial Infarction
  Rabbit Model.
  Pacing Clin. Electrophysiol., 36 (5): 596-606, 2013.


18. 松田敏夫, 吾郷由希夫, 田熊一敞:
  海馬とその周辺:うつ病における海馬.
  Clinical Neuroscience, 31(12), 1438-1440 2013. 中外医学社


19. 田熊一敞, 吾郷由希夫, 松田敏夫:
  グリア細胞Na+/Ca2+交換系の病態生理学的役割.
  生体の科学, 64 (5), 384-385, 2013.





 ★ 2012年 ★




1. Kazuhiro Takuma, Hiroyuki Mizoguchi, Yoko Funatsu, Yuko Kitahara, Daisuke Ibi,
  Hiroyuki Kamei, Toshio Matsuda, Koji Koike, Masaki Inoue, Taku Nagai, Kiyofumi Yamada:

  Placental extract improves hippocampal neuronal loss and fear memory impairment resulting
  from chronic restraint stress in ovariectomized mice.

  J. Pharmacol. Sci., 120 (2): 89-97, 2012.


2. Toshiyuki Kawasaki, Toshiyuki Marumo, Keiko Shirakami, Tomoko Mori, Hisashi Doi,
  Masaaki Suzuki, Yasuyoshi Watanabe, Shigeyuki Chaki, Atsuro Nakazato,
  Yukio Ago, Hitoshi Hashimoto, Toshio Matsuda, Akemichi Baba, Hirotaka Onoe:
  Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study
  with 11C-labeled 20-HETE synthase-specific inhibitor.
  J. Cereb. Blood Flow Metab., 32 (9): 1737-1746, 2012.


3. Kazuhiro Takuma, Tatsunori Tanaka, Tsuyoshi Takahashi, Naoki Hiramatsu, Yuki Ota,
  Yukio Ago, Toshio Matsuda:
  Neuronal nitric oxide synthase inhibition attenuates the development of
  L-DOPA-induced dyskinesia in hemi-Parkinsonian rats.
  Eur. J. Pharmacol., 683 (1-3): 166-173, 2012.


4. Kazuhiro Takuma, Hiroyuki Mizoguchi, Yoko Funatsu, Yuki Hoshina, Yukiko Himeno,
  Emiko Fukuzaki, Yuko Kitahara, Sawako Arai, Daisuke Ibi, Hiroyuki Kamei, Toshio Matsuda,
  Koji Koike, Masaki Inoue, Taku Nagai, Kiyofumi Yamada:
  Combination of chronic stress and ovariectomy causes conditioned fear memory deficits
  and hippocampal cholinergic neuronal loss in mice.
  Neuroscience, 207: 261-273, 2012.


5. Yuta Hara, Yuko Maeda, Shunsuke Kataoka, Yukio Ago, Kazuhiro Takuma, Toshio Matsuda:
  Effect of prenatal valproic acid exposure on cortical morphology in female mice.
  J. Pharmacol. Sci., 118 (4): 543-546, 2012.   


6. Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato,
  Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda:
  The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation
  rearing-induced abnormal behaviors in mice.
  J. Pharmacol. Sci., 118 (2): 295-298, 2012.


7. Yukio Ago, Tatsunori Tanaka, Yuki Kita, Hokuto Tokumoto, Kazuhiro Takuma, Toshio Matsuda:
  Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via
  modulation of prefrontal monoamine release.
  Neuropharmacology, 62 (4): 1634-1639, 2012.


8. Nobutaka Morimotoa, Satomi Kita, Masamitsu Shimazawa, Hiroko Namimatsu,
  Kazuhiro Tsuruma, Kazuhide Hayakawa, Kenichi Mishima, Nobuaki Egashira, Takuya Iyoda,
  Ichiro Horie, Yusuke Gotoh, Katsunori Iwasaki, Michihiro Fujiwara, Toshio Matsuda,
  Akemichi Baba, Issei Komuro, Kyoji Horie, Junji Takeda, Takahiro Iwamoto, Hideaki Hara:
  Preferential involvement of Na+/Ca2+ exchanger type-1 in the brain damage
  caused by transient focal cerebral ischemia in mice.
  Biochem. Biophys. Res. Commun., 429: 186-190, 2012.


9. K. Koike, Y. Yamamoto, N. Suzuki, R. Yamazaki, C. Yoshikawa, K. Takuma, K. Sugiura,
  M. Inoue:
  Efficacy of porcine placental extracts with hormone therapy for postmenopausal women
  with knee pain
  Climacteric, 15: 30-35, 2012.


10. Xiaoping Wan, Michael Cutler, Zhen Song, Alain Karma, Toshio Matsuda, Akemichi Baba,
  David S. Rosenbaum

  New experimental evidence for mechanism of arrhythmogenic membrane potential alternans
  based on balance of electrogenic INCX/ICa currents.
  Heart Rhythm, 9 (10): 1698-1705, 2012.



11. Fushun Wang, Nathan A. Smith, Qiwu Xu, Takumi Fujita, Akemichi Baba, Toshio Matsuda,
  Takahiro Takano, Lane Bekar, Maiken Nedergaard

  Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
  Sci. Signal., 5 (218): ra26, 2012.


12. Daisuke Kamimura, Tomohito Ohtani, Yasushi Sakata, Toshiaki Mano, Yasuharu Takeda,
  Shunsuke Tamaki, Yosuke Omori, Yasumasa Tsukamoto, Kazuharu Furutani, Yutaka Komiyama,
  Masamichi Yoshika, Hakuo Takahashi, Toshio Matsuda, Akemichi Baba, Satoshi Umemura,
  Takeshi Miwa, Issei Komuro, Kazuhiro Yamamoto:
  Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for
  heart failure with preserved ejection fraction.
  Eur. Heart J., 33 (11): 1408-1416, 2012.


13. Zhenghang Zhao, Hairuo Wen, Nadezhda Fefelova, Charelle Allen, Akemichi Baba,
  Toshio Matsuda, Lai-Hua Xie:
  Revisiting the Ionic Mechanisms of Early Afterdepolarizations in Cardiomyocytes:
  Predominant by Ca Waves or Ca Currents?
  Am. J. Physiol. Heart Circ. Physiol., 302 (8): H1636-H1644, 2012.


14. Meghana M Pandit, Kevin A. Strait, Toshio Matsuda, Donald E. Kohan:
  Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production.
  Am. J. Physiol. Renal Physiol., 302 (10): F1325-F1330, 2012.   


15. Ya Chen, Kevin Payne, Vindya S. Perara, Songping Huang, Akemichi Baba,
  Toshio Matsuda, Xin Yu:
  Inhibition of the sodium-calcium exchanger via SEA0400 altered manganese-induced
  T1 changes in isolated perfused rat hearts.
  NMR Biomed., 25 (11): 1280-1285, 2012.


16. Diane E Roberts, Toshio Matsuda, Ratna Bose:
  Molecular and functional characterization of the human platelet Na+/Ca2+ exchangers.
  Br. J. Pharmacol., 165 (4): 922-936, 2012.   


17. Peter Milberg, Christian Pott, Gerrit Frommeyer, Martin Fink, Matthias Ruhe, Toshio Matsuda,
  Akemichi Baba, Rainer Klocke, Trong Hung Quang, Sigrid Nikol, Jorg Stypmann, Nani Osada,
  Frank U. Müller, Günter Breithardt, Dennis Noble, Lars Eckardt:
  Acute inhibition of the Na+/Ca2+ exchanger reduces proarrhythmia in an experimental model
  of chronic heart failure.
  Heart Rhythm, 9 (4): 570-578, 2012.


18. 吾郷由希夫:
  統合失調症認知機能障害改善のアセチルコリン神経基盤に関する神経化学的研究.
  神経化学, 51 (3), 50-58, 2012.


19. 吾郷由希夫, 平松直樹, 田熊一敞, 松田敏夫:
  フルボキサミンの薬理作用におけるシグマ1受容体の関与.
  ストレス科学, 27, 104-111, 2012.


20. 平松直樹, 吾郷由希夫, 矢野耕史, 田熊一敞, 松田敏夫:
  5-HT1A受容体はフルボキサミン誘発大脳皮質ドパミン遊離促進作用に関与する.
  日本神経精神薬理学雑誌, 32, 117-118, 2012.


21. 松田敏夫:
  抗精神病薬.
  カッツング薬理学エッセンシャル, 原著9版(丸善), 260-267, 2012.


22. 松田敏夫:
  抗うつ薬.
  カッツング薬理学エッセンシャル, 原著9版(丸善), 268-276, 2012.

23. 松田敏夫:
  麻薬性鎮痛薬とアンタゴニスト.
  カッツング薬理学エッセンシャル, 原著9版(丸善), 277-285, 2012.


24. 松田敏夫:
  薬物乱用.
  カッツング薬理学エッセンシャル, 原著9版(丸善), 286-294, 2012. 21. 


25. 松田敏夫, 吾郷由希夫, 田熊一敞:
  アルツハイマー病治療薬ガランタミンの薬理学的特性とムスカリン受容体.
  日本神経精神薬理学雑誌., 32 (1), 1-8, 2012.   


26. 田熊一敞, 吾郷由希夫, 松田敏夫:
  妊娠と“くすり”―出生児の精神疾患との関連より―
  脳21., 15 (1), 79-82, 2012.   


27. 吾郷由希夫:
  5-HT1A−σ1受容体間相互作用による前頭葉ドパミン遊離調節.
  神経化学., 51 (1), 18-23, 2012.   





 ★ 2011年 ★




1. Kazuhiro Takuma, Yukio Ago, Toshio Matsuda:
  Preventive effects of an enriched environment on rodent psychiatric disorder models.
  J. Pharmacol. Sci., 117 (2): 71-76, 2011.


2. Yukio Ago, Ken Koda, Yuki Ota, Yuki Kita, Asako Fukada, Kazuhiro Takuma, Toshio Matsuda:
  Donepezil, but not galantamine, blocks muscarinic receptor-mediated in vitro and in vivo responses.
  Synapse, 65 (12): 1373-1377, 2011.


3. Yukio Ago, Toshiyuki Kawasaki, Tetsuaki Nashida, Yuki Ota, Yana Cong, Mari Kitamoto,
  Tsuyoshi Takahashi, Kazuhiro Takuma, Toshio Matsuda:
  SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP
  mouse model of Parkinson's disease.
  Neuropharmacology, 61 (8): 1441-1451, 2011.


4. Yukio Ago, Koji Yano, Naoki Hiramatsu, Kazuhiro Takuma, Toshio Matsuda:
  Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated
  mice via both 5-HT reuptake inhibition and σ1 receptor activation.
  Psychopharmacology, 217 (3): 377-386, 2011.


5. Yukio Ago, Ryota Araki, Koji Yano, Naoki Hiramatsu, Toshiyuki Kawasaki, Shigeyuki Chaki,
   Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma,
   Toshio Matsuda:
   Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced  
   hyperlocomotion and increase in prefrontal serotonergic neurotransmission.
   Psychopharmacology, 217 (3): 443-452, 2011.


6. Tetsuaki Nashida, Kazuhiro Takuma, Sayoko Fukuda, Toshiyuki Kawasaki,
   Tsuyoshi Takahashi, Akemichi Baba, Yukio Ago, Toshio Matsuda:
   The specific Na+/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced
   cytotoxicity in SH-SY5Y cells.
   Neurochem. Int., 59 (1): 51-58, 2011.


7. Yukio Ago, Ken Koda, Kazuhiro Takuma, Toshio Matsuda:
   Pharmacological aspects of the acetylcholinesterase inhibitor galantamine.
   J. Pharmacol. Sci., 116 (1): 6-17, 2011.


8. Ken Koda, Yukio Ago, Koji Yano, Momoe Nishimura, Hisako Kobayashi, Asako Fukada,
   Kazuhiro Takuma, Toshio Matsuda:
   Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice
   reared in social isolation.
   Br. J. Pharmacol., 162(3), 763-772, 2011.


9. Yukio Ago, Masanori Yoneyama, Toshihiro Ishihama, Shunsuke Kataoka, Koichi Kawada,
   Tanaka T, Kiyokazu Ogita, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma,
   Toshio Matsuda:
   Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal
   neurogenesis.
   Neuroscience, 172, 554-561, 2011.


10. Toshiyuki Kawasaki, Yukio Ago, Koji Yano, Ryota Araki, Yusuke Washida, Hirotaka Onoe,
   Shigeyuki Chaki, Atsuro Nakazato, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma,
   Toshio Matsuda:
   Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in
   isolation-reared mice.
   Neuropharmacology, 60(2-3), 397-404, 2011.


11. Hiroyuki Mizoguchi, Daisuke Ibi, Fumihiro Takase, Taku Nagai, Hiroyuki Kamei, Erika Toth, Jun Sato,
   Kazuhiro Takuma, Kiyohumi Yamada:
   Nicotine ameliorates impairment of working memory in methamphetamine-treated rats.
   Behav. Brain Res., 20; 220 (1): 159-163, 2011.


12. Hiroyuki Mizoguchi, Junya Nakade, Masaki Tachibana, Daisuke Ibi, Eiichi Someya, Hiroyuki Koike,
   Hiroyuki Kamei, Toshitaka Nabeshima, Shigemi Itohara, Kazuhiro Takuma, Makoto Sawada,
   Jun Sato, Kiyohumi Yamada:
   Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-
   treated mice by converting pro-BDNF to mature BDNF in the hippocampus.
   J. Neurosci., 7; 31 (36): 12963-12971, 2011.


13. Petoros Andrikopoulos, Akemichi Baba, Toshio Matsuda, Musutafa B.A. Djamgoz,
   Muhammad M. Yaqoob, Suzanne A. Eccles:
   Ca2+ influx through reverse-mode Na+/Ca2+ exchange is critical for vascular endothelial growth
   factor (VEGF) mediated-ERK1/2 activation and angiogenic functions of human endothelial cells.
   J. Biol. Chem., 286 (44): 37919-37931, 2011.


14. Tomer Feldmann, Michal Shahar, Akemichi Baba, Toshio Matsuda, David Lichtstein, Haim Rosen:
   The Na+/Ca2+-exchanger: An essential component in the mechanism governing cardiac
   steroid-induced slow Ca2+ oscillations.
   Cell Calcium, 50 (5): 424-432, 2011.


15. Benjamin Waghorn, Autumn Schumacher, Jimei Liu, Stephanie Jacobs, Akemichi Baba,
   Toshio Matsuda, Nathan Yanasak , Tom C.-C. Hu:
   Indirectly probing Ca2+ handling alterations following myocardial infarction in a murine model
   using T1-mapping manganese-enhanced magnetic resonance imaging.
   Magn. Reson. Med., 65(1), 239-249, 2011.





 ★ 2010年 ★




1. Tatsuya Kitao, Kazuhiro Takuma, Toshiyuki Kawasaki, Yuriko Inoue, Aki Ikehara,
  Tetsuaki Nashida, Yukio Ago, Toshio Matsuda:
  The Na+/Ca2+ exchanger-mediated Ca2+ influx triggers nitric oxide-induced cytotoxicity
  in cultured astrocytes.
  Neurochem. Int., 57(1), 58-66, 2010. 


2. Ken Koda, Yukio Ago, Yana Cong, Yuki Kita, Kazuhiro Takuma, Toshio Matsuda:
  Effects of acute and chronic administration of atomoxetine and methylphenidate on extracellular
  levels of noradrenaline, dopamine and serotonin in the prefrontal cortex and striatum of mice.
  J. Neurochem., 114(1), 259-270, 2010. 


3. Toshihiro Ishihama, Yukio Ago, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba,
  Kazuhiro Takuma, Toshio Matsuda:   
  Environmental factors during early developmental period influence psychobehavioral abnormalities
  in adult PACAP-deficient mice.   
  Behav. Brain Res., 209 (2), 274-280, 2010. 


4. Hiroyuki Mizoguchi, Daisuke Ibi, Kazuhiro Takuma, Erika Toth, Jun Sato, Shigemi Itohara, Toshitaka
  Nabeshima, Kiyohumi Yamada:
  Alterations of Emotional and Cognitive Behaviors in Matrix Metalloproteinase-2 and -9-Deficient
  Mice.
  Open Behav. Sci. J., 4, 19-25, 2010.


5. Douglas B. Kintner, Xinzhi Chen, Julia Currie, Vishal Chanana, Peter Ferrazzano, Akemichi Baba,  
  Toshio Matsuda, Mike Cohen, John Orlowski, Shing-Yan Chiu, Jack Taunton, Dandan Sun:
  Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and
  mitochondrial dysfunction following in vitro ischemia.
  J. Biol. Chem., 285(45), 35155-35168, 2010. 


6. Maki Tsumura, Reijiro Okumura, Shoko Tatsuyama, Hideki Ichikawa, Takashi Muramatsu,
  Toshio Matsuda, Akemichi Baba, Keiko Suzuki, Hiroshi Kajiya, Yoshinori Sahara, Masayuki Tokuda,
  Yasunori Momose, Masakazu Tazaki, Masaki Shimono, Yoshiyuki Shibukawa:
  Ca2+ extrusion via Na+-Ca2+ exchangers in rat odontoblasts.
  J. Endod., 36(4), 668-674, 2010. 


7. Hiroshi Ohnishi, Takaaki Murata, Shinya Kusakari, Yuriko Hayashi, Keizo Takao, Toshi Maruyama,
  Yukio Ago, Ken Koda, Feng-Jie Jin, Koichi Okawa, Per-Arne Oldenborg, Hideki Okazawa,
  Yuji Murata , Nobuhiko Furuya, Toshio Matsuda, Tsuyoshi Miyakawa, Takashi Matozaki:
  Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral
  immobility in the forced swim test.
  J. Neurosci., 30(31), 10472-10483, 2010. 


8. 吾郷由希夫:
  感覚情報処理機能障害に対するガランタミンの有効性とそのメカニズム
  薬学雑誌, 130(10), 1305-1310, 2010.


9. 田熊一敞   
  Aβトランスポーター.
  脳21, 13 (1), 59-62, 2010. 


10. 田熊一敞, 山田清文:
   記憶・学習の評価法.   
   実践行動薬理学(金芳堂), 71-78, 2010. 




 
★ 2009年 ★




1. Koji Yano, Ken Koda, Yukio Ago, Hisako Kobayashi, Toshiyuki Kawasaki, Kazuhiro Takuma,
  Toshio Matsuda:
  Galantamine improves apomorphine-induced deficits in prepulse inhibition via
  muscarinic ACh receptors in mice.
  Br. J. Pharmacol., 156(1), 173-180, 2009.


2. Rie Hosoi, Yasuyo Matsuyama, Shin-ichiro Hirose, Yutaka Koyama, Toshio Matsuda,
  Antony Gee, Osamu Inoue:
  Characterization of 14C-acetate uptake in cultured rat astrocytes.
  Brain Res., 1253, 69-73, 2009. 


3. Yuta Inokuchi, Masamitsu Shimazawa, Yoshimi Nakajima, Issei Komuro, Toshio Matsuda,
  Akemichi Baba, M. Araie, Satomi Kita, Takahiro Iwamoto, Hideaki Hara:
  A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after   
  N-methyl-D-aspartate injection and ischemia-reperfusion.
  J. Neurosci. Res., 87(4), 906-917, 2009. 


4. Cristina Camello-Almaraz, Beatriz Macias, Pedro J. Gomez-Pinilla, Soledad Alcon,
  Francisco E. Martin-Cano, Akemishi Baba, Toshio Matsuda, Pedro J. Camello, Maria J. Pozo:
  Developmental changes in Ca2+ homeostasis and contractility in gallbladder smooth muscle.
  Am. J. Physiol. Cell Physiol., 296(4), C783-C791, 2009. 


5. Toshihide Kashihara, Koichi Nakayama, Toshio Matsuda, Akemichi Baba, Tomohisa Ishikawa:
  Role of Na+/Ca2+ exchanger-mediated Ca2+ entry in pressure-induced myogenic constriction
  in rat posterior cerebral arteries.
  J. Pharmacol. Sci., 110(2), 218-222, 2009. 


6. Ben Waghorn, Yuhui Yang, Akemichi Baba, Toshio Matsuda, Autumn Schumacher,
  Nathan Yanasak, Tom C.-C. Hu:
  Assessing manganese efflux using SEA0400 and cardiac T1-mapping manganese-enhanced MRI
  in a murine model.
  NMR Biomed., 22(8), 874-881, 2009. 


7. Ryo Saito, Erina Kaneko, Yusuke Tanaka, Kenji Honda, Toshio Matsuda, Akemichi Baba,
  Issei Komuro, Satomi Kita, Takahiro Iwamoto, Yukio Takano:
  Involvement of Na+/Ca2+ exchanger in pentylenetetrazol-induced convulsion by use of Na+/Ca2+
  exchanger knockout mice.
  Biol. Pharm. Bull., 32(11), 1928-1930, 2009.  


8. Kazuhiro Takuma, Fang Fang, Wensheng Zhang, Shiqiang Yan, Emiko Fukuzaki, Heng Du,
  Alexander Sosunov, Guy McKhann, Yoko Funatsu, Noritaka Nakamichi, Taku Nagai,
  Hiroyuki Mizoguchi, Daisuke Ibi, Osamu Hori, Satoshi Ogawa, David M. Stern,
  Kiyofumi Yamada, Shirley ShiDu Yan:
  RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and
  neuronal dysfunction.
  Proc. Natl. Acad. Sci. U. S. A., 106(47), 20021-20026, 2009. 


9. Daisuke Ibi, Taku Nagai, Yuko Kitahara, Hiroyuki Mizoguchi, Hiroyuki Koike, Anna Shiraki,
  Kazuhiro Takuma, Hiroyuki Kamei, Yukihiro Noda, Atsumi Nitta, Toshitaka Nabeshima,
  Yukio Yoneda, Kiyofumi Yamada:  
  Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical
  abnormalities in adulthood.
  Neurosci. Res., 64(3), 297-305, 2009. 


10. Hiroyuki Koike, Daisuke Ibi, Hiroyuki Mizoguchi, Taku Nagai, Atsumi Nitta, Kazuhiro Takuma,
   Toshitaka Nabeshima, Yukio Yoneda, Kiyofumi Yamada:
   Behavioral abnormality and pharmacologic response in social isolation-reared mice.
   Behav. Brain Res., 202(1), 114-121, 2009. 


11. Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya,
   Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda,
   Toshitaka Nabeshima, Kiyofumi Yamada:
   Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment
   and neurotoxicity in mice.
   J. Pharmacol. Exp. Ther., 331(1), 14-22, 2009. 


12. Hiroyuki Mizoguchi, Sawako Arai, Hiroyuki Koike, Daisuke Ibi, Hiroyuki Kamei,
   Toshitaka Nabeshima, Hyoung-Chun Kim, Kazuhiro Takuma, Kiyofumi Yamada:
   Involvement of pallidotegmental neurons. 
   Psychopharmacology (Berl), 207(2), 235-243, 2009. 


13. Xinzhi Chen, Douglas B. Kintner, Akemichi Baba, Toshio Matsuda, Gary E. Shull, Dandan Sun:
   Protein aggregation in neurons following OGD: A role for Na+ and Ca2+ ionic dysregulation.
   J. Neurochem., 112(1), 173-182, 2010. 


14. 吾郷由希夫, 松田敏夫:
   ガランタミンによるムスカリン性アセチルコリン受容体活性化の機構.
   生体の科学, 60(5), 408-409, 2009.


15. 吾郷由希夫, 川﨑俊之:
   代謝型グルタミン酸受容体と精神疾患.
   脳21, 12(3), 63-69, 2009.


16. 田熊一敞, 片岡駿介, 吾郷由希夫, 松田敏夫:
   ミトコンドリア障害と神経系のアポトーシス ―アルツハイマー病解明へのアプローチ―.
   日本薬理学雑誌, 134(4), 180-183, 2009.


17. 吾郷由希夫, 田熊一敞, 松田敏夫:
   うつ病と副腎皮質ステロイドホルモン受容体.
   日本薬理学雑誌, 134(6), 304-308, 2009.  


18. 松田敏夫:
   記憶に対するグルココルチコイドの作用:促進と抑制作用.
   ストレス百科事典, 第1巻, 487-491, 2009. (Review, 翻訳)  


19. 吾郷由希夫:
   抗うつ薬の作用、グルココルチコイド受容体に対する.
   ストレス百科事典, 第2巻, 782-790, 2009. (Review, 翻訳)








 ★ 2008年 ★




1. Ken Koda, Yukio Ago, Toshiyuki Kawasaki, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda:
  Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse
  inhibitionin mice.
  Psychopharmacology, 196(2), 293-301, 2008. 


2. Daisuke Fukudome, Maki Matsuda, Toshiyuki Kawasaki, Yukio Ago, Toshio Matsuda:
  The radical scavenger edaravone counteracts diabetes in multiple low-dose
  streptozotocin-treated mice.
  Eur. J. Pharmacol., 583(1), 164-169, 2008. 


3. Naoko Adachi, Takeshi Kobayashi, Hideyuki Takahashi, Takumi Kawasaki, Yasuhito Shirai,
  Takehiko Ueyama, Toshio Matsuda, Takahiro Seki, Norio Sakai, Naoaki Saito:
  Enzymological analysis of mutant protein kinase Cγ causing spinocerebellar ataxia type 14 and
  dysfunction in Ca2+ homeostasis.
  J. Biol. Chem., 283(28), 19854-19863, 2008. 


4. Toshiyuki Kawasaki, Yukio Ago, Tatsuya Kitao, Tetsuaki Nashida, Akiko Takagi, Kazuhiro Takuma,
  Toshio Matsuda:
  A neuroprotective agent,
  T-817MA(1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate),
  prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.
  Neuropharmacology, 55(5), 654-660, 2008. 


5. Peter Milberg, Christian Pott, Martin Fink, Gerrit Frommeyer, Toshio Matsuda, Akemichi Baba,
  Nani Osada, Günter Breithardt, Dennis Noble, Lars Eckardt:
  Inhibition of the Na+/Ca2+ exchanger suppresses Torsade de Pointes in an intact heart model of
  LQT2 and LQT3.
  Heart Rhythm, 5(10), 1444 –1452, 2008. 


6. Yukio Ago, Shinsuke Arikawa, Miyuki Yata, Koji Yano, Michikazu Abe, Kazuhiro Takuma,
  Toshio Matsuda:
  Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated
  with changes in prefrontal dopamine in mouse models of depression.
  Neuropharmacology, 55(8), 1355-1363, 2008. 


7. Yukio Ago, Shigeo Nakamura, Shinsuke Arikawa, Miyuki Yata, Tsohio Matsuda:
  Involvement of prefrontal serotonergic neurons in methamphetamine-induced behavioral
  sensitization.
  Nihon Shinkei Seishin Yakurigaku Zasshi, 28(2), 85-91, 2008. 


8. Yukio Ago:
  Effects of environmental factors on behavioral abnormalities in PACAP-knockout mice.
  Yakugaku Zasshi, 128 (Suppl. 3), 83-85, 2008. 


9. Tetsuaki Nashida, Sayoko Fukuda, Toshiyuki Kawasaki, Tatsuya Kitao, Yukio Ago, Kazuhiro Takuma,
  Toshio Matsuda:
  Beneficial effect of the selective Na+/Ca2+ exchange inhibitor SEA0400 in a mouse model of
  Parkinson’s disease.
  Yakugaku Zasshi, 128 (Suppl. 3), 172-174, 2008. 


10. Yukio Ago, Shigeo Nakamura, Akemichi Baba, Toshio Matsuda:
   Neuropsychotoxicity of abused drugs: Effects of serotonin receptor ligands on
   methamphetamine- and cocaine-induced behabioral sensitization in mice.
   J. Pharmacol. Sci., 106(1), 15-21, 2008. 


11. 吾郷由希夫, 松田敏夫:
   精神機能と環境因子.
   脳21, 11, 253-259, 2008. 









 ★ 2007年 ★




1. Maiko Sato, Yukio Ago, Ken Koda, Shigeo Nakamura, Toshiyuki Kawasaki, Akemichi Baba,
  Toshio Matsuda:
  Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine
  release in rat prefrontal cortex.
  Eur. J. Pharmacol. 559(2-3), 155-160, 2007. 


2. Yuko Takayasu, Junko Nakaki, Toshiyuki Kawasaki, Ken Koda, Yukio Ago, Akemichi Baba,
  Toshio Matsuda:
  Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain.
  J. Pharmacol. Sci., 103(4), 434-437, 2007. 


3. Yukio Ago, Shigeo Nakamura, Naoko Kajita, Misato Uda, Hitoshi Hashimoto, Akemichi Baba,
  Toshio Matsuda:
  Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical  
  sensitization in mice.
  Synapse, 61(9), 757-763, 2007. 


4. Yukio Ago, Keiko Takahashi, Shigeo Nakamura, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda:
  Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.
  J. Pharmacol. Sci., 104(2), 153-158, 2007. 


5. Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Akemichi Baba, and Toshio Matsuda:
  Edaravone, a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
  -induced neurotoxicity in the substantia nigra but not the striatum.
  J. Pharmacol. Exp. Ther., 322(1), 274-281, 2007. 


6. Harumi Fujii, Toshihiro Ishihama, Yukio Ago, Norihito Shintani, Michiya Kakuda, Hitoshi Hashimoto,
  Akemichi Baba, Toshio Matsuda:
  Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice.
  Peptides, 28(9), 1674-1679, 2007. 


7. Toshiyuki Kawasaki, Tatsuya Kitao, Katsuhiro Nakagawa, Hiroko Fujisaka, Yoshimi Takegawa,
  Ken Koda, Yukio Ago, Akemichi Baba, Toshio Matsuda:
  Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical
  scavenger.
  Glia, 55(13), 1325-1333, 2007. 


8. Pedro J. Gomez-Pinilla, Maria J. Pozo, Akemishi Baba, Toshio Matsuda, Pedro J. Camello:
  Ca2+ extrusion in aged smooth muscle cells.
  Biochem Pharmacol., 74(6), 860-869. 2007. 


9. Hai Chen, Douglas B. Kintner, Mathew Jones, Toshio Matsuda, Akemichi Baba, Lech Kiedrowski,
  Dandan Sun:
  AMPA-mediated excitotoxicity in oligodendrocytes: role for Na+-K+-Cl- co-transport and
  reversal of Na+/Ca2+ exchanger.
  J. Neurochem., 102(6), 1783-1795, 2007. 


10. Yutaka Koyama, Akemichi Baba, Toshio Matsuda:
   Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil
   chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of
   an endothelin ETB receptor agonist.
   Neuroreport, 18(12), 1275-1279, 2007. 


11. Yutaka Koyama, Akemichi Baba, Toshio Matsuda:
   Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression
   of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain.
   Neuroscience, 147(3), 620-630, 2007. 


12. 吾郷由希夫, 角田亨也, 橋本 均, 馬場明道, 松田敏夫:
   統合失調症とセロトニン1A受容体 (Review).
   脳21, 10, 256-260, 2007.







 ★ 2006年 ★




1. Takayuki Nagano, Shinya H. Kimura, Eri Takai, Toshio Matsuda, Motohiko Takemura:
  Lipopolysaccharide sensitizes microglia towards Ca2+-induced cell death: mode of cell death
  shifts from apoptosis to necrosis.
  Glia 53(1), 67-73, 2006. 


2. Tetsuo Fukushima, Masahiro Koide, Yukio Ago, Akemichi Baba, Toshio Matsuda:
  T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial
  dysfunction in cortical neurons.
  Neurochem. Int. 48(2), 124-130, 2006. 


3. Kazuhiro Tanaka, Norihito Shintani, Hitoshi Hashimoto, Naofumi Kawagishi, Yukio Ago,
  Toshio Matsuda, Ryota Hashimoto, Hiroshi Kunugi, Akiko Yamamoto, Chihiro Kawaguchi,
  Takeshi Shimada, Akemichi Baba:
  Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits
  in Adcyap1-deficinet mice.
  J. Neurosci. 26(19), 5091-5097, 2006. 


4. Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Shigeo Nakamura, Soichi Itoh, Akemichi Baba,
  Toshio Matsuda:
  Protective effect of the radical scavenger edaravone against methamphetamine-induced
  dopaminergic neurotoxicity in mouse striatum.
  Eur. J. Pharmacol. 542(1-3), 92-99, 2006. 


5. R. Arthur Bouwman, Kanita Salic, F. Gieneke Padding, Etto C. Eringa, Brechje J. van Beek-Harmsen,
  Toshio Matsuda, Akemichi Baba, Rene J.P. Musters, Walter J. Paulus, Jaap J. de Lange and Christa
  Boer:
  Cardioprotection via activation of protein kinase C-δ depends on modulation of the reverse mode
  of the Na+/Ca2+ exchanger.
  Circulation 114[suppl I], I-226-I-232. 2006. 


6. Yukio Ago, Shigeo Nakamura, Misato Uda, Yasushi Kajii, Michikazu Abe, Akemichi Baba,
  Toshio Matsuda:
  Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single
  and repeated methamphetamine in mice.
  Neuropharmacology 51(4), 914-922, 2006. 


7. Norihito Shintani, Hitoshi Hashimoto, Kazuhiro Tanaka, Naofumi Kawagishi, Chihiro Kawaguchi,
  Michyoshi Hatanaka, Yukio Ago, Toshio Matsuda, Akemichi Baba:
  Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap-/-).
  Ann. NY Acad. Sci. 1070, 545-549, 2006. 


8. Soichi Itoh, Naomi Teraoka, Toshio Matsuda, Kousuke Okamoto, Tatsuya Takagi, Charles Oo,
  H. Danny Kao:
  Reciprocating dialysis tube method: periodic tapping improved in vitro release/dissolution
  testing of suppositories.
  Eur. J. Pharm. Biopharm., 64(3), 393-398, 2006. 


9. Yutaka Koyama, Masashi Kiyo-oka, Masakazu Osakada, Naotaka Horiguchi, Norihito Shintani,
  Yukio Ago, Michiya Kakuda, Akemichi Baba, Toshio Matsuda:
  Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell
  proliferation.
  Brain Res. 1112(1), 65-69, 2006. 


10. Shigeo Nakamura, Yukio Ago, Aiko Hayashi, Soichi Itoh, Michiya Kakuda, Hitoshi Hashimoto,
   Akemichi Baba, Toshio Matsuda:
   Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor
   agonist/antagonist in mice.
   Synapse, 60(7), 479-484, 2006. 


11. E. Bradley, M.A. Hollywood, L. Johnston, R.J. Large, T. Matsuda, A. Baba, N.G. McHale, K.D.
   Thornbury, G.P. Sergeant:
   Contribution of reverse Na+-Ca2+ exchange to spontaneous activity in interstitial cells of Cajal
   in the rabbit urethra.
   J. Physiol. 574(Pt 3), 651-661. 2006. 


12. Toshio Matsuda, Takayuki Nagano, Motohiko Takemura, Akemichi Baba:
   Topics on the Na+/Ca2+ exchanger: responses of Na+/Ca2+ exchanger to interferon-γ
   and nitric oxide in cultured microglia (Review).
   J. Pharmacol. Sci. 102(1), 22-26, 2006. 


13. Yukio Ago, Shigeo Nakamura, Aiko Hayashi, Soichi Itoh, Akemichi Baba, Toshio Matsuda:
   Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization
   in mice.
   Pharmacol. Biochem. Behav. 85(1), 198-205, 2006. 


14. Toshiya Harasawa, Yukio Ago, Soichi Itoh, Akemichi Baba, Toshio Matsuda:
   Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior
   in mice.
   Behav. Pharmacol. 17(7), 637-640, 2006. 


15. Yukio Ago, Maiko Sato, Shigeo Nakamura, Akemichi Baba, Toshio Matsuda:
   Lack of enhanced effect of antipsychotics combined with fluvoxamine on acetylcholine release
   in rat prefrontal cortex.
   J. Pharmacol. Sci. 102(4), 419-422, 2006. 







 ★ 2005年 ★




1. Y. Ago, S. Nakamura, A. Baba, T. Matsuda:
  Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively
  in rat prefrontal cortex.
  Neuropsychopharmacology 30(1), 43-51, 2005. 


2. N. Shintani, S. Suetake, H. Hashimoto, K. Koga, A. Kasai, C. Kawaguchi, Y. Morita, M. Hirose,
  Y. Sakai, S. Tomimoto, T. Matsuda, A. Baba:
  Neuroprotective action of endogenous PACAP in cultured rat cortical neurons.
  Regul. Pept. 126(1-2), 123-128, 2005. 


3. T. Nagano, M. Osakada, Y. Ago, Y. Koyama, A. Baba, S. Maeda, M. Takemura, T. Matsuda:
  SEA0400, a selective inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside
  -induced apoptosis in cultured rat microglia.
  Br. J. Pharmacol. 144(5), 669-679, 2005. 


4. T. Matsuda, Y. Koyama, A. Baba:
  Functional proteins involved in regulation of intracellular Ca2+ for drug development:
  Pharmacology of SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger inhibitor (Review).
  J. Pharmacol. Sci. 97(3), 339-343, 2005. 


5. Y. Koyama, K. Tsujikawa, T. Matsuda, A. Baba:
  Endothelin increases expression of exon III- and exon IV-containing brain-derived neurotrophic
  factor transcripts in cultured astrocytes and rat brain.
  J. Neurosci. Res. 80(6), 809-816, 2005. 


6. Y. Ago, T. Harasawa, S. Itoh, S. Nakamura, A. Baba, T. Matsuda:
  Antidepresasnt-like effect of coadministration of sulpiride and fluvoxamine in mice.
  Eur. J. Pharmacol. 520(1-3), 86-90, 2005. 

7. Y. Koyama, A. Baba, T. Matsuda:
  Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes.
  Neuroscience 136, 425-433, 2005. 


8. Y. Ago, S. Nakamura, A. Baba, T. Matsuda:
  Mechanism for serotonin1A receptor activation-induced reversal of methamphetamine-induced
  behavioral sensitization in mice: a study using microdialysis.
  Yakugaku Zasshi 125 (Suppl. 2), 31-33, 2005.


9. S. Nakamura, Y. Ago, A. Baba, T. Matsuda:
  Effect of the selective serotonin1A receptor agonist osemozotan on cocaine-induced behavioral
  sensitization in mice.
  Yakugaku Zasshi 125 (Suppl. 2), 104-105, 2005.


10. S. Nakamura, Y. Ago, S. Itoh, Y. Koyama, A. Baba, T. Matsuda:
   Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex.
   Eur. J. Pharmacol. 528(1-3), 95-98, 2005. 


11. 田熊一敞, 山田清文, 松田敏夫:
   グリア細胞の遅発性アポトーシス.
   Clinical Neuroscience (中外医学社) 23, 181-183, 2005.


12. 松田敏夫, 馬場明道:
   抗てんかん薬.
   カッツング薬理学, 原著9版 (丸善株式会社) 419-442, 2005.


13. 松田敏夫, 馬場明道:
   全身麻酔薬.
   カッツング薬理学, 原著9版 (丸善株式会社) 443-459, 2005.


14. 松田敏夫:
   薬の副作用.
   スタンダード薬学シリーズ6 日本薬学会編 薬と疾病
   Ⅰ.薬の効くプロセス, (東京化学同人) 47-50, 2005.







 ★ 2004年 ★




1. R. Enomoto, H. Tatsuoka, T. Komai, C. Sugahara, K. Takemura, A. Yamauchi, M. Nishimura,
  S. Naito, T. Matsuda, E. Lee:
  Involvement of histone phosphorylation in apoptosis of human astrocytes after exposure to
  saline solution.
  Neurochem. Int. 44, 459-467, 2004. 


2. T. Iwamoto, S. Kita, A. Uehara, I. Imanaga, T. Matsuda, A. Baba, T. Katsuragi:
  Molecular determinants of Na+/Ca2+ exchange (NCX1) inhibition by SEA0400.
  J. Biol. Chem. 279, 7544-7553, 2004. 


3. R. Bouchard, A. Omelchenko, H.D. Le, P. Choptiany, T. Matsuda, A. Baba, K. Takahashi, D.A.
  Nicoll, K.D. Philipson, M. Hnatowich, L.V. Hryshko:
  Effects of SEA0400 on mutant NCX1.1 Na+-Ca2+ exchangers with altered ionic regulation.
  Mol. Pharmacol. 65, 802-810, 2004. 


4. Y. Koyama, S. Matsui, S. Itoh, M. Osakada, A. Baba, T. Matsuda:
  The selective Na+-Ca2+ exchange inhibitor attenuates brain edema after radiofrequency lesion
  in rats.
  Eur. J. Pharmacol. 489, 193-196, 2004. 


5. T. Nagano, Y. Kawasaki, A. Baba, M. Takemura, T. Matsuda:
  Upregulation of Na+-Ca2+ exchange activity by interferon-γ in cultured rat microglia.
  J. Neurochem. 90, 784-791. 2004. 


6. Y. Koyama, Y. Yoshioka, M. Shinde, T. Matsuda, A. Baba:
  Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured
  astrocytes.
  J. Neurochem. 90, 904-912, 2004. 


7. P. Phuagphong, T. Fukushima, R. Hatanaka, K. Tanaka, A. Baba, T. Matsuda:
  T-588, a cognitive enhancer, protects against sodium nitroprusside-induced toxicity
  in cultured astrocytes.
  J. Pharmacol. Sci. 95, 135-138, 2004. 


8. Y. Koyama, H. Egawa, M. Osakada, A. Baba, T. Matsuda:
  Increase by FK960, a novel cognitive enhancer, in glial cell line-derived neurotrophic factor
  production in cultured rat astrocytes.
  Biochem. Pharmacol. 68, 275-282, 2004. 


9. C. Lee, N.S. Visen, N.S. Dhalla, H.D. Le, M. Isaac, P. Choptiany, G. Gross, A. Omelchenko,
  T. Matsuda, A. Baba, K. Takahashi, M. Hnatowich, L.V. Hryshko:
  Inhibitory profile of SEA0400 [2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline]
  assessed on the cardiac Na+-Ca2+ exchanger, NCX1.1.
  J. Pharmacol. Exp. Ther. 311, 748-757, 2004. .


10. A. Kasai, N. Shintani, M. Oda, M. Kakuda, H. Hashimoto, T. Matsuda, S. Hinuma, A. Baba:
   Apelin is a novel angiogenic factor in retinal endothelial cells.
   Biochem. Biophys. Res. Commun. 325, 395-400, 2004. 


11. 吾郷由希夫, 中村茂生, 原澤俊也, 松田敏夫:
   スルピリドとフルボキサミンの併用による抗うつ様作用と前頭葉ドパミン遊離促進作用.
   新薬と臨床, 53, 48-53, 2004.


12. 橋本 均, 新谷紀人, 松田敏夫, 馬場明道
   GPCRシグナリングの機能解析:神経ペプチドPACAP欠損マウスの表現型.
   日薬理誌, 124, 9P-10P, 2004.


13. 小山 豊, 馬場明道, 松田敏夫:
   エンドセリンによるアストロサイトの神経栄養因子産生促進.
   日薬理誌, 124, 121P-122P, 2004.


14. T. Takahashi, K. Takahashi, M. Onishi, T. Suzuki, Y. Tanaka, T. Ota, S. Yoshida, S. Nakaike,
   T. Matsuda, A. Baba:
   Effects of SEA0400, a novel inhibitor of the Na+/Ca2+ exchanger, on myocardial stunning
   in anesthetized dogs.
   Eur. J. Pharmacol. 505, 163-168, 2004. 


15. X. Luo, A. Baba, T. Matsuda, C. Romano:
   Susceptibilities to and mechanisms of excitotoxic cell death of adult mouse inner retinal
   neurons in dissociated culture.
   Investigative Ophtalmology & Visual Science 45, 4576-4582, 2004. 


16. K. Takuma, A. Baba, T. Matsuda:
   Astrocyte apoptosis: implications for neuroprotection.
   Prog. Neurobiol. 72(2), 111-127, 2004. 


17. 小山 豊, 松田敏夫:
   アストロサイトを標的とした脳機能改善薬の開発.
   生産と技術, 56, 44-46, 2004.


18. 松田敏夫, 小山 豊, 馬場明道:
   新規脳機能改善薬FK960のGDNF産生の促進.
   Clinical Neuroscience (中外医学社) 22, 311-313, 2004.


19. 松田敏夫, 小山 豊:
   Na+-Ca2+交換系阻害薬.
   脳21, (金芳堂)7, 85-89, 2004.








 ★ 2003年 ★




1. M. Sakaue, Y. Ago, C. Sowa, Y. Koyama, A. Baba, T. Matsuda:
  The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice
  in the elevated plus-maze.
  Eur. J. Pharmacol. 458, 141-144, 2003. 


2. K. Takahashi, T. Takahashi, T. Suzuki, M. Onishi, Y. Tanaka, A. Hamano-Takahashi, T. Ota,
  K. Kameo, T. Matsuda, A. Baba:
  Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger,
  on myocardial ischemia-reperfusion injuries.
  Eur. J. Pharmacol. 458, 155-162, 2003. 


3. K. Takuma, M. Kiriu, K. Mori, E. Lee, R. Enomoto, A. Baba, T. Matsuda:
  Roles of cathepsins in reperfusion-induced apoptosis in cultured astrocytes.
  Neurochem. Int. 42, 153-159, 2003. 


4. Y. Koyama, K. Tsujikawa, T. Matsuda, A. Baba:
  Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression
  of GDNF and BDNF in rat.
  Eur. J. Neurosci. 18, 887-894, 2003. 


5. Y. Koyama, Y. Yoshioka, T. Matsuda, A. Baba:
  Focal adhesion kinase is required for endothelin-induced cell cycle progression in cultured 
  astrocytes.
  Glia 43, 185-189, 2003. 


6. Y. Koyama, K. Tsujikawa, T. Matsuda, A. Baba:
  Endothelin-1 stimulates glial cell line-derived neurotrophic factor expression in cultured rat
  astrocytes.
  Biochem. Boiphys. Res. Commun. 303, 1101-1105, 2003. 


7. K. Yamamoto, H. Hashimoto, S. Tomimoto, N. Shintani, J. Miyazaki, F. Tashiro, H. Aihara, T. Nammo,
  M. Li, K. Yamagata, J. Miyagawa, Y. Matsuzawa, Y. Kawabata, Y. Fukuhama, K. Koga, W. Mori,
  K. Tanaka, T. Matsuda, A. Baba:
  Overexpression of PACAP in transgenic mouse pancreatic β-cells enhances insulin secretion and
  ameliorates streptozotocin-induced diabetes.
  Diabetes 52, 1155-1162, 2003. 


8. M. Sakaue, Y. Ago, A. Baba, T. Matsuda:
  The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficit of
  prepulse inhibition in mice.
  Psychopharmacology 170, 73-79, 2003. 


9. A. Yamamuro, Y. Ago, S. Maeda, Y. Sakai, A. Baba, T. Matsuda:
  Protective effect of T-588 on toxic damage by serum deprivation and amyloid-β protein
  in cultured neurons.
  J. Pharmacol. Sci. 92, 153-156. 2003. 


10. A. Yamamuro, Y. Ago, K. Takuma, S. Maeda, Y. Sakai, A. Baba, T. Matsuda:
   Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588.
   Neurochem. Res. 28, 1779-1783, 2003. 


11. I. Yokoyama, Y. Sakai, Y. Hatayama, S. Tsuji, Y. Koyama, A. Baba, T. Matsuda:
   T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated
   kinases in the hippocampus.
   Cognitive Brain Res.17, 522-525, 2003. 


12. Y. Ago, Y. Koyama, A. Baba, T. Matsuda:
   Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex.
   Neuropharmacology 45, 1050-1056, 2003. 


13. 吾郷由希夫, 松田敏夫:
   長期隔離飼育マウス脳の無拘束マイクロダイアリシス法.
   日薬理誌, 122, 135-140, 2003.


14. 小阪田正和, 松田敏夫:
   GDNFによるパーキンソン病の治療.
   日薬理誌, 122, 556, 2003.








 ★ 2002年 ★




1. K. Takuma, P. Phuagphong, Y. Koyama, E. Lee, R. Enomoto, K. Mori, A. Baba, T. Matsuda:
  Anti-apoptotic and cytotoxic Effects of the Nitric Oxide Donor NOC12 in Cultured Rat Astrocytes.
  Jpn. J. Pharmacol. 89, 64-71, 2002. 


2. M. Sakaue, Y. Ago, C. Sowa, Y. Sakamoto, B. Nishihara, Y. Koyama, A. Baba, T. Matsuda:
  Modulation by 5-HT2A receptors of aggressive behavior in isolated mice.
  Jpn. J. Pharmacol. 89, 89-92, 2002. 


3. K. Takuma, K. Mori, E. Lee, R. Enomoto, A. Baba, T. Matsuda:
  Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes.
  Brain Res. 946, 232-238, 2002. 


4. H. Reuter, S.A. Henderson, T. Han, T. Matsuda, A. Baba, R.S. Ross, J.I. Goldhaber, K.D. Philipson:
  Knockout mice for pharmacological screening testing for specificity of Na+-Ca2+ exchange
  inhibitors.
  Circ. Res. 91, 90-92, 2002. 


5. Y. Ago, M. Sakaue, A. Baba, T. Matsuda:
  Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo
  in the frontal cortex of mice.
  J. Neurochem. 83, 353-359, 2002. 


6. 小山 豊:
  脳傷害時のアストログリアの機能変化とその細胞内機構.
  日薬理誌, 119, 135-143, 2002.


7. 小山 豊:
  NSAIDによるアミロイドβペプチド42産生の抑制.
  日薬理誌, 119, 262, 2002.








 ★ 2001年 ★




1. K. Takuma, E. Lee, R. Enomoto, K. Mori, A. Baba and T. Matsuda:
  Ibudilast attenuates astrocyte apoptosis via cyclic GMP signaling pathway in an in vitro
  reperfusion model.
  Br. J. Pharmacol. 133, 541-548, 2001. 


2. T. Matsuda, N. Arakawa, K. Takuma, Y. Kishida, Y. Kawasaki, M. Sakaue, K. Takahashi, T. Takahashi,
  T. Suzuki, T. Ota, A. Hamano-Takahashi, M. Onishi, Y. Tanaka, K. Kameo and A. Baba:
  SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion
  injury in the in vitro and in vivo cerebral ischemic models.
  J. Pharmacol. Exp. Ther. 298, 249-256, 2001. 


3. T. Matsuda, M. Sakaue, Y. Ago, Y. Sakamoto, Y. Koyama and A. Baba:
  Functional alteration of brain dopaminergic system in isolated aggressive mice.
  Jpn. J. Neuropsychopharmacol. 21, 71-76, 2001. .


4. M. Sakaue, Y. Ago, C. Murakami, C. Sowa, Y. Sakamoto, Y. Koyama, A. Baba, T. Matsuda:
  Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT1A receptor
  activation in isolated mice.
  Eur. J. Pharmadcol. 432, 163-166, 2001. 


5. H. Hashimoto, N. Shintani, K. Tanaka, W. Mori, M. Hirose, T. Matsuda, M. Sakaue, J. Miyazaki,
  H. Niwa, F. Tashiro, K. Yamamoto, K. Koga, S. Tomimoto, A. Kunugi, S. Suetake and A. Baba:
  Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide
  (PACAP).
  Proc. Natl. Acad. Sci. USA. 98, 13355-13360, 2001. .


6. K. Takuma, P. Phuagphong, E. Lee, K. Mori, A. Baba and T. Matsuda:
  Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase
  of mitochondrial permeable transition pore.
  J. Biol. Chem. 276, 48093-48099, 2001. .


7. 松田敏夫:
  セロトニンレセプターと薬.
  ファルマシア, 37, 307-311, 2001.


8. T. Matsuda, K. Takuma and A. Baba:
  Signaling pathways to prevent astrocyte apoptosis.
  Recent Res. Devel. Neurochem. 4, 89-96, 2001.


9. 小山 豊:
  アクアポリン-4と脳浮腫.
  日薬理誌, 118, 289, 2001.


10. 小山 豊:
   脳とエンドセリン.
   脳21, 4, 73-78, 2001.