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最近の発表論文

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2016年


<原著論文>

New 3-alkylpyridine alkaloid, N-methylniphatyne A as an inhibitor of cancer cells adapted to nutrient starvation from an Indonesia marine sponge of Xestospongia sp.  
*Arai, M.; Kamiya, K.; Shin, D.; Matsumoto, H.; Hisa, T.; Setiawan, A.; Kotoku, N.; *Kobayashi, M.
Chem. Pharm. Bull. 2016, In press.
(This article is dedicated to Professor Satoshi Ōmura in celebration of his 2015 Nobel Prize.)

Furospinosulin-1, marine spongean furanosesterterpene, suppresses the growth of hypoxia-adapted cancer cells by binding to transcriptional regulators p54nrb and LEDGF/p75.  link
*Arai, M.; Kawachi, T.; Kotoku, N.; Nakata, C.; Kamada, H.; Tsunoda, S.; Tsutsumi, Y.; Endo, H.; Inoue, M.; Sato, H.; *Kobayashi, M.
ChemBioChem 2016, 17, 181-189.
Selected as an Inside Cover in the issue

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<総説・解説等>

活性天然物の標的分子解析による新規薬剤標的の探索  link
荒井雅吉
薬学雑誌 2016, 136, 669―676.

Search for Anti-angiogenic Substances from Natural Sources.   link
Kotoku, N.; Arai, M.; Kobayashi, M.
Chem. Pharm. Bull. 2016, 64, 119-127.

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2015年


<原著論文>

Structure-activity relationship and in vivo anti-tumor evaluation of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge.  link
Sumii, Y.; *Kotoku, N.; Fukuda, A.; Kawachi, T.; Sumii, Y.; Arai, M.; *Kobayashi, M.
Marine Drugs 2015, 13, 7419-7432.

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Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.  link
*Arai, M.; Kamiya, K.; Pruksakorn, P.; Sumii, Y.; Kotoku, N.; Joubert, J.-P.; Moodley, P.; Han, C.; Shin, D.; *Kobayashi, M.
Bioorg. Med. Chem. 2015, 23, 3534-3541.

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Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge  link
Sumii, Y.; *Kotoku, N.; Fukuda, A.; Kawachi, T.; Sumii, Y.; Arai, M.; *Kobayashi, M.
Bioorg. Med. Chem. 2015, 23, 966-975.

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Identification and functional analysis of 2-hydroxyflavanone C-glucosyltransferase in soybean (Glycine max).  link
*Hirade, Y.; Kotoku, N.; Terasaka, K.; Saijo-Hamano, Y.; Fukumoto, A.; Mizukami, H.
FEBS Lett. 2015, 589, 1778-1786.

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2014年


<原著論文>

Specialized transduction designed for precise high-throughput unmarked deletions in Mycobacterium tuberculosis  link
Jain, P.; Hsu, T.; Arai, M.; Biermann, K.; Thaler, D. S.; Nguyen, A.; Gonzalez, P. A.; Tufariello, J. M.; Kriakov, J.; Chen, B.; Larsen, M. H.; Jacobs, W. R., Jr.
mBio 2014, 5, e01245/1-e01245/10.

Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner  link
Kotoku, N.; Higashimoto, K.; Kurioka, M.; Arai, M.; Fukuda, A.; Sumii, Y.; Sowa, Y.; Sakai, T.; Kobayashi, M.
Bioorg. Med. Chem. Lett. 2014, 24, 3389-3391.

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Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells  link
Arai, M.; Kawachi, T.; Sato, H.; Setiawan, A.; Kobayashi, M.
Bioorg. Med. Chem. Lett. 2014, 68, 3155-3157.

Enantiospecific synthesis and cytotoxicity evaluation of ligudentatol: A programmed aromatization approach to the 2,3,4-trisubstituted phenolic motif via visible-light-mediated group transfer radical cyclization  link
Moustafa, G. A. I.; Suizu, H.; Aoyama, H.; Arai, M.; Akai, S.; Yoshimitsu, T.
Chem. Asian J. 2014, 9, 1506-1510.

Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances  link
Arai, M.; Han, C.; Yamano, Y.; Setiawan, A.; Kobayashi, M.
J. Nat. Med. 2014, 68, 372-376.

Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor  link
Kotoku, N.; Nakata, C.; Kawachi, T.; Sato, T.; Guo, X.; Ito, A.; Sumii, Y.; Arai, M.; Kobayashi, M.
Bioorg. Med. Chem. 2014, 22, 2102-2112.

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Identification of target protein of agelasine D, a marine spongean diterpene alkaloid, as an anti-dormant mycobacterial substance.  link
Arai, M.; Yamano, Y.; Setiawan, A.; Kobayashi, M.
ChemBioChem 2014, 15, 117-123.

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<総説・解説等>

海洋天然物furospinosulin-1由来のフォトアフィニティープローブ分子の合成
古徳直之
化学工業 2014, 65, 282―288.

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2013年


<原著論文>

Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2.  link
Kotoku, N.; Mizushima, K.; Tamura, S.; Kobayashi, M.
Chem. Pharm. Bull. 2013, 61, 1024-1029.

Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species.  link
Arai, M.; Niikawa, H.; Kobayashi, M.
J. Nat. Med. 2013, 67, 271-275.

An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses.  link
Li, Z.; Shigeoka, D.; Caulfield, T. R.; Kawachi, T.; Qiu, Y.; Kamon, T.; Arai, M.; Tun, H. W.; Yoshimitsu, T.
MedChemComm 2013, 4, 1093-1098.

Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis.  link
Moustafa, G. A. I.; Nojima, S.; Yamano, Y.; Aono, A.; Arai, M.; Mitarai, S.; Tanaka, T.; Yoshimitsu, T.
MedChemComm 2013, 4, 720-723.

<総説・解説等>

“Search for New Medicinal Seeds from Marine Organisms”
Kobayashi, M.; Kotoku, N.; Arai, M.
Chembiomolecular Science: At the Frontier of Chemistry and Biology (Springer) 2013, pp. 93―101.

Cortistatin A をモチーフとする抗腫瘍活性リード化合物の創製  link
古徳直之
薬学雑誌 2013, 133, 867―872.

海洋天然物cortistatin Aを基盤とする抗腫瘍活性リード化合物の創製
小林資正、古徳直之
MEDCHEM NEWS 2013, 23, 30―35.

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2012年


<原著論文>

Creation of Readily Accessible and Orally Active Analogue of Cortistatin A.  link
Kotoku, N.; Sumii, Y.; Hayashi, T.; Tamura, S.: Kawachi, T.; Shiomura, S.; Arai, M.; Kobayashi, M.
ACS Med. Chem. Lett. 2012, 3, 673-677.
Featured in In This Issue (Vol. 3, Issue 8, 2012)
Most Read Articles ranked #14 (July, 2012)

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Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.  link
Yamano, Y,; Arai, M,; Kobayashi, M.
Bioorg. Med. Chem. Lett. 2012, 22, 1877-4881.

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Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp.  link
Arai, M.; Yamano, Y.; Fujita, M.; Setiawan, A.; Kobayashi, M.
Bioorg. Med. Chem. Lett. 2012, 22, 1818-1821.

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Asymmetric Total Synthesis of (—)-Stenine and 9a-epi-Stenine.   link
Fujioka, H.; Nakahara, K.; Kotoku, N.; Ohba, Y.; Nagatomi, Y.; Wang, T.-L.; Sawama, Y.; Murai, K.; Hirano, K.; Oki, T.; Wakamatsu, S.; Kita, Y.
Chem. Eur. J. 2012, 18, 13861-13870.

<総説・解説等>

Implementation of "collaborative development of advanced practical education program to train pharmacists with leadership" under the joint operation of pharmaceutical departments of fourteen national universities.  
Hirata, K.; Tamura, S.; Kobayashi, M.
Yakugaku Zasshi 2012, 132, 339-343.

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2011年


<原著論文>

Antiproliferative effect of aaptamine on human chronic myeloid leukemia K562 cells.  link
Jin, M.; Zhao, W.; Zhang, Y.; Kobayashi, M.; Duan, H.; Kong, D.
Int. J. Mol. Sci. 2011, 12, 7352-7359.

Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium species.  link
Ishida, S.; Arai, M.; Nikawa, H.; Kobayashi, M.
Biol. Pharm. Bull. 2011, 34, 917-920.

Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp.  link
Pruksakorn, P.; Arai, M.; Liu, L.; Moodley, P.; Jacobs, W. R., Jr.; Kobayashi, M.
Biol. Pharm. Bull. 2011, 34, 1287-1290.

Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge.  link
Kotoku, N.; Fujioka, S.; Nakata, C.; Yamada, M.; Sumii, Y.; Kawachi, T.; Arai, M.; Kobayashi, M.
Tetrahedron 2011, 67, 6673-6678.

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Synthetic study of carbocyclic core of cortistatin a, an anti-angiogenic steroidal alkaloid from marine sponge.  link
Kotoku, N.; Sumii, Y.; Hayashi, T.; Kobayashi, M.
Heterocycles 2011, 83, 1535-1552.

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DedA protein relates to action-mechanism of halicyclamine A, a marine spongean macrocyclic alkaloid, as an anti-dormant mycobacterial substance.  link
Arai, M.; Liu, L.; Fujimoto, T.; Setiawan, A.; Kobayashi, M.
Marine Drugs 2011, 9, 984-993.

Stereoselective Synthesis of Core Structure of Cortistatin A.  link
Kotoku, N.; Sumii, Y.; Kobayashi, M.
Org. Lett. 2011, 13, 3514-3517.

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Antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone.  link
Kong, D.; Yamori, T.; Kobayashi, M.; Duan, H.
Marine Drugs 2011, 9, 154-161.

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega.  link
Arai, M.; Hayashi, A.; Sobou, M.; Ishida, S.; Kawachi, T.; Kotoku, N.; Kobayashi, M.
J. Nat. Med. 2011, 65, 149-156.
J. Nat. Med. 誌 平成24年度論文賞

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2010年


<原著論文>

Hypoxia-Selective Growth Inhibition of Cancer Cells by Furospinosulin-1, a Furanosesterterpene Isolated from an Indonesian Marine Sponge.  link
Arai, M.; Kawachi, T.; Setiawan, A.; Kobayashi, M.
ChemMedChem 2010, 5, 1919-1926.

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Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity.  link
Kotoku, N.; Guo, X.; Arai, M.; Kobayashi, M.
Bioorg. Med. Chem. Lett. 2010, 20, 4152-4155.

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Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria.  link
Pruksakorn, P.; Arai, M.; Kotoku, N.; Vilcheze, C.; Baughn, A. D.; Moodley, P.; Jacobs, W. R., Jr.; Kobayashi, M.
Bioorg. Med. Chem. Lett. 2010, 20, 3658-3663.

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<総説・解説等>

Search for medicinal seeds from marine organisms.  
Arai, M.; Kobayashi, M.
Yuki Gosei Kagaku Kyokaishi 2010, 68, 470-479.

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2009年


<原著論文>

Haliclonacyclamines, tetracyclic alkylpiperidine alkaloids, as anti-dormant mycobacterial substances from a marine sponge of Haliclona sp.  link
Arai, M.; Ishida, S.; Setiawan, A.; Kobayashi, M.
Chem. Pharm. Bull. 2009, 57, 1136-1138.

Pyripyropenes, fungal sesquiterpenes conjugated with α-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells.  link
Hayashi, A.; Arai, M.; Fujita, M.; Kobayashi, M.
Biol. Pharm. Bull. 2009, 32, 1261-1265.

Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death.  link
Suna, H.; Arai, M.; Tsubotani, Y.; Hayashi, A.; Setiawan, A.; Kobayashi, M.
Bioorg. Med. Chem. 2009, 17, 3968-3972.

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New Rev-export inhibitor from Alpinia galanga and structure-activity relationship.  link
Tamura, S.; Shiomi, A.; Kaneko, M.; Ye, Y.; Yoshida, M.; Yoshikawa, M.; Kimura, T.; Kobayashi, M.; Murakami, N.
Bioorg. Med. Chem. Lett. 2009, 19, 2555-2557.

Study of Palau white clay on cosmetic material. (1). Inhibitory effect on melanin formation.  
Moriura, T.; Park, S.; Hong, W.; Kobayashi, M.; Yoshikawa, M.
Fragrance J. 2009, 37, 59-62.

<総説・解説等>

Analysis of pharmacological active components from herbal medicine with unique structure.
Kobayashi, M.
Rinsho Kensa 2009, 53, 909-915.

Chemical biology of marine natural products.
Arai, M.; Kobayashi, M.
Kagaku to Seibutsu 2009, 47, 275-282.

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2008年


<原著論文>

Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells.   link
Kong, D.; Aoki, S.; Sowa, Y.; Sakai, T.; Kobayashi, M.
Marine Drugs 2008, 6, 480-488.

Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge.  link
Kotoku, N.; Sumii, Y.; Hayashi, T.; Kobayashi, M.
Tetrahedron Lett. 2008, 49, 7078-7081.

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Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.  link
Kotoku, N.; Hiramatsu, A.; Tsujita, H.; Hirakawa, Y.; Sanagawa, M.; Aoki, S.; Kobayashi, M.
Arch. Pharm. 2008, 341, 568-577.

Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent.  link
Arai, M.; Sobou, M.; Vilcheze, C.; Baughn, A.; Hashizume, H.; Pruksakorn, P.; Ishida, S.; Matsumoto, M.; Jacobs, W. R., Jr.; Kobayashi, M.
Bioorg. Med. Chem. 2008, 16, 6732-6736.

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Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge.  link
Kotoku, N.; Tamada, N.; Hayashi, A.; Kobayashi, M.
Bioorg. Med. Chem. Lett. 2008, 18, 3532-3535.

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<総説・解説等>

Discovery of pharmaceutical seeds from materials derived from marine life.
Kobayashi, M.
Shinki Sozai Tansaku 2008, 33-42.

New anticancer agent for targeting angiogenesis.
Arai, M.; Kobayashi, M.
Kagaku (Kyoto, Japan) 2008, 63, 72-73.

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2007年


<原著論文>

The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line.   link
Matsui, T.; Sowa, Y.; Murata, H.; Takagi, K.; Nakanishi, R.; Aoki, S.; Yoshikawa, M.; Kobayashi, M.; Sakabe, T.; Kubo, T.; Sakai, T.
Int. J. Oncology 2007, 31, 915-922.

Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived fungus Aspergillus candidus IF10.   link
Wei, H.; Inada, H.; Hayashi, A.; Higashimoto, K.; Pruksakorn, P.; Kamada, S.; Arai, M.; Ishida, S.; Kobayashi, M.
J. Antibiot. 2007, 60, 586-590.

Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids.  link
Aoki, S.; Watanabe, Y.; Tanabe, D.; Arai, M.; Suna, H.; Miyamoto, K.; Tsujibo, H.; Tsujikawa, K.; Yamamoto, H.; Kobayashi, M.
Bioorg. Med. Chem. 2007, 15, 6758-6762.

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Stereoselective total synthesis of arenastatin A, a spongean cytotoxic depsipeptide.  link
Kotoku, N.; Narumi, F.; Kato, T.; Yamaguchi, M.; Kobayashi, M.
Tetrahedron Lett. 2007, 48, 7147-7150.

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Crambescidin 800, a pentacyclic guanidine alkaloid, protects a mouse hippocampal cell line against glutamate-induced oxidative stress.   link
Suna, H.; Aoki, S.; Setiawan, A.; Kobayashi, M.
J. Nat. Med. 2007, 61, 288-295.

Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata.   link
Aoki, S.; Sanagawa, M.; Watanabe, Y.; Setiawan, A.; Arai, M.; Kobayashi, M.
Bioorg. Med. Chem. 2007, 15, 4818-4828.

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Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex.  link
Aoki, S.; Watanabe, Y.; Tanabe, D.; Setiawan, A.; Arai, M.; Kobayashi, M.
Tetrahedron Lett. 2007, 48, 4485-4488.

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Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex.  link
Watanabe, Y.; Aoki, S.; Tanabe, D.; Setiawan, A.; Kobayashi, M.
Tetrahedron 2007, 63, 4074-4079.

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Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.  link
Zimhony, O.; Vilcheze, C.; Arai, M.; Welch, J. T.; Jacobs, W. R., Jr.
Antimicrob. Agents Chemother. 2007, 51, 752-754.

Concise asymmetric total synthesis of scyphostatin, a potent inhibitor of neutral sphingomyelinase.  link
Fujioka, H.; Sawama, Y.; Kotoku, N.; Ohnaka, T.; Okitsu, T.; Murata, N.; Kubo, O.; Li, R.; Kita, Y.
Chem. Eur. J. 2007, 13, 10225-10238.

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2006年


<原著論文>

A functional role of intracellular loops of human multidrug resistance protein 1.  link
Ren, X.; Furukawa, T.; Yamamoto, M.; Aoki, S.; Kobayashi, M.; Nakagawa, M.; Akiyama, S.
J. Biochem. 2006, 140, 313-318.

Synthesis of 15,20-triamide analog with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide.  link
Kotoku, N.; Kato, T.; Narumi, F.; Ohtani, E.; Kamada, S.; Aoki, S.; Okada, N.; Nakagawa, S.; Kobayashi, M.
Bioorg. Med. Chem. 2006, 14, 7446-7457.

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Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells.  link
Aoki, S.; Cho, S.; Hiramatsu, A.; Kotoku, N.; Kobayashi, M.
J. Nat. Med. 2006, 60, 231-235.

A novel synthetic drug, LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells.  link
Izumi, M.; Yogosawa, S.; Aoki, S.; Watanabe, H.; Kamiyama, J.; Takahara, Y.; Sowa, Y.; Kobayashi, M.; Hosoi, H.; Sugimoto, T.; Sakai, T.
Int. J. Oncology 2006, 29, 169-173.

Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells.  link
Aoki, S.; Cho, S.; Ono, M.; Kuwano, T.; Nakao, S.; Kuwano, M.; Nakagawa, S.; Gao, J.; Mayumi, T.; Shibuya, M.; Kobayashi, M.
Anti-Cancer Drugs 2006, 17, 269-278.

Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner.  link
Aoki, S.; Kong, D.; Suna, H.; Sowa, Y.; Sakai, T.; Setiawan, A.; Kobayashi, M.
Biochem. Biophys. Res. Commun. 2006, 342, 101-106.

Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex.  link
Aoki, S.; Watanabe, Y.; Sanagawa, M.; Setiawan, A.; Kotoku, N.; Kobayashi, M.
J. Am. Chem. Soc. 2006, 128, 3148-3149.

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Shimalactones, neuritogenic polyketides from a marine-derived fungus Emericella variecolor GF10.  link
Wei, H.; Itoh, T.; Kotoku, N.; Kobayashi, M.
Heterocycles 2006, 68, 111-123.

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Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.  link
Vilcheze, C.; Wang, F.; Arai, M.; Hazbon, M. H.; Colangeli, R.; Kremer, L.; Weisbrod, T. R.; Alland, D.; Sacchettini, J. C.; *Jacobs, W. R., Jr.
Nature Medicine 2006, 12, 1027-1029.

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2005年


<原著論文>

MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (b-D-glucuronate).   link
Noguchi, T.; Ren, X.; Aoki, S.; Igarashi, Y.; Che, X.; Nakajima, Y.; Takahashi, H.; Mitsuo, R.; Tsujikawa, K.; Sumizawa, T.; Haraguchi, M.; Kobayashi, M.; Goto, S.; Kanehisa, M.; Aikou, T.; Akiyama, S.; Furukawa, T.
Biochem. Pharmacol. 2005, 70, 1056-1065.

Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10.   link
Wei, H.; Itoh, T.; Kinoshita, M.; Kotoku, N.; Aoki, S.; Kobayashi, M.
Tetrahedron 2005, 61, 8054-8058.

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Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge.   link
Kotoku, N.; Tsujita, H.; Hiramatsu, A.; Mori, C.; Koizumi, N.; Kobayashi, M.
Tetrahedron 2005, 61, 7211-7218.

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Absolute stereo-structure of kendarimide A, a novel MDR modulator, from a marine sponge.   link
Kotoku, N.; Cao, L.; Aoki, S.; Kobayashi, M.
Heterocycles 2005, 65, 563-578.

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GSH Inhibits Trypsinization of the C-terminal Half of Human MRP1.  link
Ren, X.; Furukawa, T.; Nakajima, Y.; Takahashi, H.; Aoki, S.; Sumizawa, T.; Haraguchi, M.; Kobayashi, M.; Chijiiwa, K.; Akiyama, S.
J. Biol. Chem. 2005, 280, 6231-6237.

Asymmetric synthesis by the intramolecular haloetherification reaction of ene acetal: discrimination of prochiral dienes in cyclohexane systems.   link
20) Fujioka, H.; Kotoku, N.; Sawama, Y.; Kitagawa, H.; Ohba, Y.; Wang, T.; Nagatomi, Y.; Kita, Y.
Chem. Pharm. Bull. 2005, 53, 952-957.


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