大阪大学 大学院薬学研究科 薬剤学分野

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論文

2019年

(原著論文)

Ago Y, Tanabe W, Higuchi M, Tsukada S, Tanaka T, Yamaguchi T, Igarashi H, Yokoyama R, Seiriki K, Kasai A, Nakazawa T, Nakagawa S, Hashimoto K, Hashimoto H. (R)-ketamine induces a greater increase in prefrontal 5-HT release than (S)-ketamine and ketamine metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol, in press.

Baba M, Yokoyama K, Seiriki K, Naka Y, Matsumura K, Kondo M, Yamamoto K, Hayashida M, Kasai A, Ago Y, Nagayasu K, Hataya-Takano A, Takahashi A, Yamaguchi S, Mori D, Ozaki N, Yamamoto T, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in mouse model of 3q29 deletion syndrome. Neuropsychopharmacology, 44: 2125-2135, 2019.

Matsumura K, Baba M, Nagayasu K, Yamamoto K, Kondo M, Kitagawa K, Takemoto T, Seiriki K, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Kuriu T, Iguchi T, Sato M, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T. Autism-associated protein kinase D2 regulates embryonic cortical neuron development. Biochem Biophys Res Commun, 519: 626-632, 2019.

Ishimoto K, Miki S, Ohno A, Nakamura Y, Otani S, Nakamura M, Nakagawa S. β-Carotene solid dispersion prepared by hot-melt technology improves its solubility in water. J Food Sci Technol, 56: 3540-3546, 2019 .

Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H. Optimized FAST for whole-brain imaging at subcellular resolution. Nat Protoc, 14: 1509-1529, 2019

Hayata-Takano A, Kamo T, Kijima H, Seiriki K, Ogata K, Ago Y, Nakazawa T, Shintani Y, Higashino K, Nagayasu K, Shintani N, Kasai A, Waschek JA, Hashimoto H. Pituitary adenylate cyclase-activating polypeptide modulates dendritic spine maturation and morphogenesis via microRNA-132 upregulation. J Neurosci 39:4208-4220, 2019.

Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H. mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model. Pharmacol Biochem Behav 176:1-5, 2019.

Shirakura K, Ishiba R, Kashio T, Funatsu R, Tanaka T, Fukada SI, Ishimoto K, Hino N, Kondoh M, Ago Y, Fujio Y, Yano K, Doi T, Aird WC, Okada Y. The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation. J Cell Sci 132, jcs220228, 2019

Hiraki Y, Araki R, Fujiwara H, Ago Y, Tanaka T, Toume K, Matsumoto K, Yabe T. Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice. J Pharmacol Sci 139:72-76, 2019

2018年

(原著論文)

Higashida S, Nagai H, Nakayama K, Shinohara R, Taniguchi M, Nagai M, Hikida T, Yawata S, Ago Y, Kitaoka S, Narumiya S, Furuyashiki T. Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety. Sci Rep 8: 10454, 2018.

Xie Z, Ago Y, Okada N, Tachibana M. Valproic acid attenuates the immunosuppressive function of myeloid-derived suppressor cells. J Pharmacol Sci 137: 359-365, 2018.

Morikawa N, Tachibana M, Ago Y, Goda H, Sakurai F, Mizuguchi H. LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth. Biol Pharm Bull 41:1866-1869, 2018.

Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki S, Shintani Y, Shintani N, Hashimoto H. Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism. EMBO Rep 19: e44860, 2018.

Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H. β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. PLoS One 13: e0196946, 2018.

(著書/総説論文)

吾郷由希夫. うつ/不安症状に対するσ1受容体-セロトニン1A受容体の機能的相互作用による治療・創薬戦略. 医薬品医療機器レギュラトリーサイエンス, 49: 550-556, 2018.

吾郷由希夫, 早田敦子, 橋本 均. 精神疾患におけるVPAC2受容体の病態生理学的役割. 日本薬理学雑誌 151 (6): 249-253, 2018.

吾郷由希夫, 深田宗一朗. 骨格筋活動と精神疾患. 実験医学増刊 36 (7): 138-142, 2018.

2017年

(原著論文)

Hirobe S, Otsuka R, Iioka H, Quan YS, Kamiyama F, Asada H, Okada N, Nakagawa S. Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo. Life Sci 168: 24-27, 2017.

伊藤沙耶美, 中川晋作, 岡田直貴. マイクロニードル技術を活用した経皮ワクチン製剤の開発. Drug Delivery System 32 (1): 39-45, 2017.

2016年

(原著論文)

Inoo K, Inagaki R, Fujiwara K, Sasawatari S, Kamigaki T, Nakagawa S, Okada N. Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research. Mol Ther Oncolytics 3: 16024, 2016.

Wan L, Yao X, Faiola F, Liu B, Zhang T, Tabata Y, Mizuguchi H, Nakagawa S, Gao JQ, Zhao RC. Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells. Int J Nanomedicine 11: 6763-6769, 2016.

Matsuo K, Hirobe S, Okada N, Nakagawa S. Analysis of skin permeability and toxicological properties of amorphous silica particles. Biol Pharm Bull 39: 1201-1205, 2016.

Kusabuka H, Fujiwara K, Tokunaga Y, Hirobe S, Nakagawa S, Okada N. Highly efficient gene transfer using a retroviral vector into murine T cells for preclinical chimeric antigen receptor-expressing T cell therapy. Biochem Biophys Res Commun 473: 73-79, 2016.

Kamei K, Kawabata H, Asakura M, Samosornsuk W, Hienoya A, Nakagawa S, Yamasaki S. Cytolethal distending toxin gene-based multiplex PCR assay for Campylobacter jejuni, C. coli, C. fetus, C. upsaliensis, C. hyointestinalis and C. lari. Jpn J Infect Dis 69: 256-258, 2016.

(著書/総説論文)

廣部祥子, 岡田直貴, 中川晋作. マイクロニードルを用いた経皮ワクチン製剤. ファルマシア 52 (11): 1030-1034, 2016.

廣部祥子, 岡田直貴, 中川晋作. 新たなワクチン投与法-経皮ワクチン-. 化学療法の領域 32 (6): 100-108, 2016.

廣部祥子, 岡田直貴, 中川晋作. 感染症対策に貢献する経皮ワクチン製剤の開発. 医薬品医療機器レギュラトリーサイエンス 47 (2): 93-100, 2016.

廣部祥子, 岡田直貴, 中川晋作. 次世代ワクチンとしての経皮ワクチン製剤. 薬剤学-生命とくすり- 76 (1): 18-24, 2016.

2015年

(原著論文)

Kamei K, Hatanaka N, Asakura M, Somroop S, Samosornsuk W, Hinenoya A, Misawa N, Nakagawa S, Yamasaki S. Campylobacter hyointestinalis Isolated from Pigs Produces Multiple Variants of Biologically Active Cytolethal Distending Toxin. Infect Immun 83: 4304-4313, 2015.

Nagano K, Imai S, Zhao X, Yamashita T, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Nakagawa S, Tsutsumi Y, Tsunoda S. Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors. Int J Oncol 47: 195-203, 2015.

Hirobe S, Azukizawa H, Hanafusa T, Matsuo K, Quan YS, Kamiyama F, Katayama I, Okada N, Nakagawa S. Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch. Biomaterials 57: 50-58, 2015.

(著書/総説論文)

岡田直貴, 中川晋作. 細胞治療. PHARM TECH JAPAN 31 (2): 119-125, 2015.

中川晋作. マイクロニードルが拓く化粧品の未来. 日本香粧品学会誌 39: 162-165, 2015.

廣部祥子, 岡田直貴, 中川晋作. 次世代ワクチンとしての経皮ワクチン製剤. 薬剤学 76 (1): 18-24, 2015.

2014年

(原著論文)

Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, García-Cardeña G, Aird WC, Doi T. Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter. Arterioscler Thromb Vasc Biol 34: 1531-1538, 2014.

Yao X, Zhou N, Wan L, Su X, Sun Z, Mizuguchi H, Yoshioka Y, Nakagawa S, Zhao RC, Gao JQ. Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells. Biochem Biophys Res Commun 447: 383-387, 2014.

Kamei K, Asakura M, Somroop S, Hatanaka N, Hinenoya A, Nagita A, Misawa N, Matsuda M, Nakagawa S, Yamasaki S. A PCR-RFLP assay for the detection and differentiation of Campylobacter jejuni, C. coli, C. fetus, C. hyointestinalis, C. lari, C. helveticus and C. upsaliensis. J Med Microbiol 63(Pt 5): 659-666, 2014.

Matsuo K, Okamoto H, Kawai Y, Quan YS, Kamiyama F, Hirobe S, Okada N, Nakagawa S. Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease. J Neuroimmunol 266: 1-11, 2014.

(著書/総説論文)

廣部祥子, 岡田直貴, 中川晋作. 予防接種を簡便にする「貼るワクチン」の開発. 臨床と微生物 41 (6): 711-717, 2014.

廣部祥子, 岡田直貴, 中川晋作. ワクチン開発におけるDDS. 医薬ジャーナル 50 (7): 1797-1803, 2014.

廣部祥子, 岡田直貴, 中川晋作. 経皮ワクチン. BIOINDUSTRY 31 (6): 18-26, 2014.

廣部祥子, 岡田直貴, 中川晋作. 貼るワクチン製剤の開発. PHARM TECH JAPAN 30 (4): 717-723, 2014.

廣部祥子, 岡田直貴, 中川晋作. マイクロニードルワクチンの可能性. 最新醫學 69 (4): 872-879, 2014.

2013年

(原著論文)

Hiraishi Y, Hirobe S, Iioka H, Quan YS, Kamiyama F, Asada H, Okada N, Nakagawa S. Development of a novel therapeutic approach using a retinoic acid-loaded microneedle patch for seborrheic keratosis treatment and safety study in humans.
J Control Release 171: 93-103, 2013.

Hirobe S, Azukizawa H, Matsuo K, Zhai Y, Quan YS, Kamiyama F, Suzuki H, Katayama I, Okada N, Nakagawa S. Development and clinical study of a self-dissolving microneedle patch for transcutaneous immunization device. Pharm Res 30: 2664-2674, 2013.

Matsuo K, Ishii Y, Kawai Y, Saiba Y, Quan YS, Kamiyama F, Hirobe S, Okada N, Nakagawa S. Analysis of transcutaneous antigenic protein delivery by a hydrogel patch formulation. J Pharm Sci 102: 1936-1947, 2013.

Yoshikawa M, Mukai Y, Okada Y, Tsumori Y, Tsunoda S, Tsutsumi Y, Aird WC, Yoshioka Y, Okada N, Doi T, Nakagawa S. Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody. Blood 121: 2804-2813, 2013.

Morishige T, Yoshioka Y, Narimatsu S, Ikemizu S, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S. Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy. Cytokine 61: 578-584, 2013.

Kanagawa N, Yanagawa T, Nakagawa T, Okada N, Nakagawa S. Tumor vessel-injuring ability improves antitumor effect of cytotoxic T lymphocytes in adoptive immunotherapy. Cancer Gene Ther 20: 57-64, 2013.

Hiraishi Y, Nakagawa T, Quan YS, Kamiyama F, Hirobe S, Okada N, Nakagawa S. Performance and characteristics evaluation of a sodium hyaluronate-based microneedle patch for a transcutaneous drug delivery system. Int J Pharm 441: 570-579, 2013.

(著書/総説論文)

Matsuo K, Hirobe S, Okada N, Nakagawa S. Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery. Vaccine 31 (19): 2403-2415, 2013.

Hirobe S, Okada N, Nakagawa S. Transcutaneous vaccines: current and emerging strategies. Expert Opin Drug Deliv 10 (4): 485-498, 2013.

廣部祥子, 岡田直貴, 中川晋作. 経皮ワクチン開発の現状と将来. 小児内科 45 (11): 2043-2048, 2013.

廣部祥子, 岡田直貴, 中川晋作. マイクロニードル型経皮ワクチン製剤の実用化を目指して.感染・炎症・免疫 43(3): 259-262, 2013.

中川岳志, 岡田直貴, 中川晋作. キメラ抗原受容体 (CAR) 発現細胞傷害性T細胞 (CTL) を用いた次世代養子免疫療法の開発. Drug Delivery System 28 (1): 35-44, 2013.

向 洋平, 中川晋作. ポリγグルタミン酸ナノ粒子によるER-endosome fusionに基づく抗原の効率的なクロスプレゼンテーション. 臨床免疫・アレルギー科 59 (3): 379-385, 2013.

2012年

(原著論文)

Shimizu T, Ichihara M, Yoshioka Y, Ishida T, Nakagawa S, Kiwada H.
Intravenous administration of polyethylene glycol-coated (PEGylated) proteins and PEGylated adenovirus elicits an anti-PEG immunoglobulin M response. Biol Pharm Bull 35: 1336-1342, 2012.

Yao XL, Yoshioka Y, Ruan GX, Chen YZ, Mizuguchi H, Mukai Y, Okada N, Gao JQ, Nakagawa S. Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy. Biomacromolecules 13: 2402-2409, 2012.

Matsuo K, Hirobe S, Yokota Y, Ayabe Y, Seto M, Quan YS, Kamiyama F, Tougan T, Horii T, Mukai Y, Okada N, Nakagawa S. Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza. J Control Release 160: 495-501, 2012.

Morishige T, Yoshioka Y, Inakura H, Tanabe A, Narimatsu S, Yao X, Monobe Y, Imazawa T, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S. Suppression of nanosilica particle-induced inflammation by surface modification of the particles. Arch Toxicol 86: 1297-1307, 2012.

Matsui H, Sakurai F, Katayama K, Yamaguchi T, Okamoto S, Takahira K, Tachibana M, Nakagawa S, Mizuguchi H. A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X.
Biomaterials 33: 3743-3755, 2012.

Matsuo K, Yokota Y, Zhai Y, Quan YS, Kamiyama F, Mukai Y, Okada N, Nakagawa S. A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens. J Control Release 161: 10-17, 2012.

Hirobe S, Matsuo K, Quan YS, Kamiyama F, Morito H, Asada H, Takaya Y, Mukai Y, Okada N, Nakagawa S. Clinical study of transcutaneous vaccination using a hydrogel patch for tetanus and diphtheria. Vaccine 30: 1847-1854, 2012.

(著書/総説論文)

廣部祥子, 岡田直貴, 中川晋作. 経皮ワクチンの進歩と展望. 臨床免疫・アレルギー科 58 (3): 313-321, 2012.

権 英淑, 中川晋作. 化粧品・医薬品デバイスとしてのマイクロニードルの開発. 生産と技術64 (2): 63-68, 2012.

向 洋平, 清野智史, 中川晋作. がんの早期診断を目指した腫瘍ターゲティング型MRI造影剤の開発. 磁気と健康 24: 6-10, 2012.

2011年

(原著論文)

Li N, Peng LH, Chen X, Nakagawa S, Gao JQ. Effective transcutaneous immunization by antigen-loaded flexible liposome in vivo. Int J Nanomedicine 6: 3241-3250, 2011.

Matsuo K, Ishii Y, Quan YS, Kamiyama F, Asada H, Mukai Y, Okada N, Nakagawa S. Compositional optimization and safety assessment of a hydrogel patch as a transcutaneous immunization device. Biol Pharm Bull 34: 1835-1840, 2011.

Mukai Y, Yoshinaga T, Yoshikawa M, Matsuo K, Yoshikawa T, Matsuo K, Niki K, Yoshioka Y, Okada N, Nakagawa S. Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles. J Immunol 187: 6249-6255, 2011.

Narimatsu S, Yoshioka Y, Morishige T, Yao X, Tsunoda S, Tsutsumi Y, Nishimura MI, Mukai Y, Okada N, Nakagawa S. Structure-activity relationship of T-cell receptors based on alanine scanning. Biochem Biophys Res Commun 415: 558-562, 2011.

Narimatsu S, Yoshioka Y, Watanabe H, Masano T, Morishige T, Yao X, Tanabe A, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S. Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation. Cytokine 56: 489-493, 2011.

Yao X, Yoshioka Y, Morishige T, Eto Y, Narimatsu S, Kawai Y, Mizuguchi H, Gao JQ, Mukai Y, Okada N, Nakagawa S. Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy. Mol Ther 19: 1619-1625, 2011.

Abe Y, Yoshikawa T, Inoue M, Nomura T, Furuya T, Yamashita T, Nagano K, Nabeshi H, Yoshioka Y, Mukai Y, Nakagawa S, Kamada H, Tsutsumi Y, Tsunoda S. Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning. Biomaterials 32: 5498-5504, 2011.

Matsuo K, Ishii Y, Quan YS, Kamiyama F, Mukai Y, Okada N, Nakagawa S. Characterization of transcutaneous protein delivery by a hydrogel patch in animal, human, and tissue-engineered skin models. Biol Pharm Bull 34: 586-589, 2011.

Katayama K, Furuki R, Yokoyama H, Kaneko M, Tachibana M, Yoshida I, Nagase H, Tanaka K, Sakurai F, Mizuguchi H, Nakagawa S, Nakanishi T. Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector. Biomaterials 32: 4185-4193, 2011.

Matsuo K, Koizumi H, Akashi M, Nakagawa S, Fujita T, Yamamoto A, Okada N. Intranasal immunization with poly(γ-glutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity. J Control Release 152: 310-316, 2011.

Yoshikawa M, Mukai Y, Tsunoda S, Tsutsumi Y, Yoshioka Y, Okada N, Nakagawa S. Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif. J Biosci Bioeng 111: 597-599, 2011.

Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N, Nakagawa S, Mayumi T, Tsunoda S, Tsutsumi Y. Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application. Biomaterials 32: 2713-2724, 2011.

Suzuki-Kouyama E, Katayama K, Sakurai F, Yamaguchi T, Kurachi S, Kawabata K, Nakagawa S, Mizuguchi H. Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction. Biomaterials 32: 1724-1730, 2011.

Imai S, Nagano K, Yoshida Y, Okamura T, Yamashita T, Abe Y, Yoshikawa T, Yoshioka Y, Kamada H, Mukai Y, Nakagawa S, Tsutsumi Y, Tsunoda S. Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins. Biomaterials 32: 162-169, 2011.

Matsuo K, Ishii Y, Quan YS, Kamiyama F, Mukai Y, Yoshioka Y, Okada N, Nakagawa S. Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat. J Control Release 149: 15-20, 2011.

Nomura T, Abe Y, Kamada H, Shibata H, Kayamuro H, Inoue M, Kawara T, Arita S, Furuya T, Yamashita T, Nagano K, Yoshikawa T, Yoshioka Y, Mukai Y, Nakagawa S, Taniai M, Ohta T, Serada S, Naka T, Tsunoda S, Tsutsumi Y. Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice. J Control Release 149: 8-14, 2011.

(著書/総説論文)

Li N, Peng LH, Chen X, Nakagawa S, Gao JQ. Transcutaneous vaccines: advances in technology and delivery for overcoming the barriers. Vaccine 29 (37): 6179-6190, 2011.

Yao XL, Nakagawa S, Gao JQ. Current targeting strategies for adenovirus vectors in cancer gene therapy. Curr Cancer Drug Targets 11 (7): 810-825, 2011.

松尾一彦, 岡田直貴, 中川晋作. マイクロニードル型経皮ワクチン製剤 (貼るワクチン) の開発. 綜合臨牀 60 (11): 2211-2214, 2011.

松尾一彦, 岡田直貴, 中川晋作. 感染症予防対策に資する経皮免疫製剤 (貼るワクチン) の開発. 日本臨牀 69 (9): 1561-1566, 2011.

吉岡靖雄, 中川晋作, 堤 康央. インフラマソームの活性とシリカ粒子の性状. 生体の科学 62 (3): 228-232, 2011.

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