20152014201320122011|2010|20092008
 
  2010年度

Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Minowa K., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology.
Pharmazie., 65(2):93-96, 2010. [PubMed]

Morishige T., Yoshioka Y., Tanabe A., Yao X., Mizuguchi, H., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models.
Int. Immunopharmacol., 10(1):26-33, 2010. [PubMed]

Yoshioka Y., Watanabe H., Morishige T., Yao X., Ikemizu S., Nagao C., Ahmad S., Mizuguchi K., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system.
Biomaterials., 31(7):1935-1943, 2010. [PubMed]

Shibata H., Abe Y., Yoshioka Y., Nomura T., Sato M., Kayamuro H., Kawara T., Arita S., Furuya T., Nagano K., Yoshikawa T., Kamada H., Tsunoda S., Tsutsumi Y.
Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1- or TNFR2
Cytokine., 50(1):75-83, 2010. [PubMed]

Morishige T., Yoshioka Y., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.
Biochem. Biophys. Res. Commun., 392(2):160-165, 2010. [PubMed]

Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy.
Biomaterials., 31(12):3357-3363, 2010. [PubMed]

Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor.
Biochem. Biophys. Res. Commun., 393(4):888-893, 2010. [PubMed]

Nabeshi H., Yoshikawa T., Matsuyama K., Nakazato Y., Arimori A., Isobe M., Tochigi S., Kondoh S., Hirai T., Akase T., Yamashita T., Yamashita K., Yoshida T., Nagano K., Abe Y., Yoshioka Y., Kamada H., Imazawa T., Itoh N., Tsunoda S., Tsutsumi Y.
Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells.
Pharmazie., 65(3):199-201, 2010. [PubMed]

Kayamuro H., Abe Y., Yoshioka Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Kawai Y., Mayumi T., Hiroi T., Itoh N., Nagano K., Kamada H., Tsunoda S., Tsutsumi Y.
Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV.
Pharmazie., 65(4):254-6, 2010. [PubMed]

Yamashita K., Yoshioka Y., Higashisaka K., Morishita Y., Yoshida T., Fujimura M., Kayamuro H., Nabeshi H., Yamashita T., Nagano K., Abe Y., Kamada H., Kawai Y., Mayumi T., Yoshikawa T., Itoh N., Tsunoda S., Tsutsumi Y.
Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape.
Inflammation., 33(4):276-80, 2010. [PubMed]

Yoshida T., Yoshioka Y., Fujimura M., Kayamuro H., Yamashita K., Higashisaka K., Nakanishi R., Morishita Y., Nabeshi H., Yamashita T., Muroi M., Tanamoto K., Nagano K., Abe Y., Kamada H., Kawai Y., Mayumi T., Itoh N., Yoshikawa T., Tsunoda S., Tsutsumi Y.
Urban aerosol induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo.
Biol. Pharm. Bull., 33(5):780-3, 2010. [PubMed]

Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Narimatsu S., Monobe Y., Imazawa T., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture.
Biomaterials., 31(26):6833-6842, 2010. [PubMed]

Nabeshi H., Yoshikawa T., Kamada H., Shibata H., Sugita T., Abe Y., Nagano K., Nomura T., Minowa K., Tsunoda S., Tsutsumi Y.
Arsenic trioxide alters expression and oxidative modification of the proteome in leukemic cells.
Pharmazie., 65:702-707, 2010. [PubMed]

Mukai Y., Nakamura T., Yoshikawa M., Yoshioka Y., Tsunoda S., Nakagawa S., Yamagata Y., Tsutsumi Y.
Solution of the structure of the TNF-TNFR2 complex.
Science Signaling., 3(148), ra83:1-10, 2010. [PubMed]

Morishige T., Yoshioka Y., Inakura H., Tanabe A., Yao X., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.
Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties.
Pharmazie., 65(8):596-599, 2010. [PubMed]

Kayamuro H., Yoshioka Y., Abe Y., Arita S., Katayama K., , Nomura T., Yoshikawa T., Kubota-Koketsu R., Ikuta K., Okamoto S., Mori Y., Kunisawa J., Kiyono H., Itoh N., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus.
J. Virol., 84(24):12703-12712, 2010. [PubMed]

Yoshida T., Yoshioka Y., Fujimura M., Yamashita K., Higashisaka K., Nakanishi R., Morishita Y., Kayamuro H., Nabeshi H., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshikawa T., Itoh N., Tsutsumi Y.
Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.
Toxicol. Lett., 199(3):383-388, 2010. [PubMed]

吉川友章, 吉岡靖雄, 角田慎一, 堤 康央
化粧品ナノマテリアルの安全性評価の現状と技術的課題~安全なナノマテリアルの開発支援に向けて~.
コスメティックステージ., Vol.4(4), 44-48, 2010.

Nabeshi H., Yoshikawa T., Imazawa T., Tsunoda S., Tsutsumi Y.
Safety Asessment of Nanomaterials Using Toxicokinetics and Toxicoproteome Analysis.
Yakugaku Zasshi., 130(4):465-470, 2010. [PubMed]

Nagano K., Imai S., Nakagawa S., Tsunoda S., Tsutsumi Y.
From disease proteomics to biomarker development -Establishment of antibody proteomics technology and exploration of cancer-related biomarkers-
Yakugaku Zasshi., 130(4):487-492, 2010. [PubMed]

Kayamuro H., Yoshioka Y., Abe Y., Katayama K., Hiroi T., Tsunoda S., Tsutsumi Y.
Application of bioactive mutant TNF alpha to a mucosal vaccine adjuvant.
Yakugaku Zasshi., 130(1):55-61, 2010. [PubMed]

Nomura T., Abe Y., Yoshioka Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
Creation of TNFR1-selective antagonist, and its therapeutic effects.
Yakugaku Zasshi., 130(1):63-68, 2010. [PubMed]

Yamashita T., Utoguchi N., Suzuki R., Nagano K., Tunoda S., Tsutsumi Y., Maruyama K.
Development of anti-tumor blood vessel antibodies by phage display method.
Yakugaku Zasshi., 130(4):479-485, 2010. [PubMed]

吉川友章, 吉岡靖雄, 角田慎一, 堤 康央
ナノ材料のリスク評価と安全性対策『非晶質ナノシリカの経皮吸収性/生体内動態と安全性との連関追求』.
フロンティア出版., 44-53, 2010.

堤 康央
ナノマテリアルのヒト健康への影響.,
阪大NEWS LETTER., Vol.48(6): 19, 2010.

吉川友章, 吉岡靖雄, 堤 康央
革新的技術/素材の恩恵を最大限に享受した豊かな社会の構築に向けて ~ナノマテリアルの安全性確保基盤の構築を例に~.
生産と技術., 6(4):52-56, 2010.

堤 康央
創薬プロテオミクスとDDSの融合によるバイオ医薬の開発に向けて.,
Progress in Drug Delivery System., <Biomedical Research Foundation (Tokyo)>, XIX:5-10, 2010.

Yoshioka Y., Yoshikawa T., Tsutsumi Y.
Nano-safety science for assuring the safety of nanomaterials.
Nippon Eiseigaku Zassh., 65(4):487-492, 2010. [PubMed]

萱室裕之, 角田慎一, 堤 康央
新規粘膜ワクチンアジュバントとしての機能性サイトカインの開発.
Drug Delivery System., 25(1):22-28, 2010.


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