Research
Faculty Members
Stem Cell Regeneration and Adaptation（Biology）
Fukada So-ichiroProfessor
EDUCATION:
Graduate School of Pharmaceutical Sciences, Osaka University (2003)
CERTIFICATES:
Pharmacist’s license (1998)
EDITORIAL ACTIVITIES:
Member of the Editorial Board of Skeletal Muscle
Associate Editor of Frontiers in Cell Dev Biol
MY FAVORITE PHRASES:
In the middle of difficulty lies opportunity (-Albert Einstein)
Research theme
Maintenance mechanisms of muscle stem cell
One of our research interests is to reveal molecular mechanisms underlying the maintenance of muscle stem cells (MuSCs: satellite cells) as decline of MuSC-pool is involved in many types of muscular diseases. Based on the original findings, we aim to find and develop therapeutic approaches for muscular disorders including muscular dystrophy, sarcopenia, and cancer cachexia.
Elucidation of molecular mechanism underlying muscle regeneration and plasticity
Regeneration and plasticity are unique abilities in skeletal muscle. Relayed signaling between MuSCs and mesenchymal progenitors (also known as FAPs) are essential for orchestrated process of these abilities. In order to establish innovative therapeutic approaches for muscular atrophy including sarcopenia, we have challenged to identify pathways involved in muscle regeneration and plasticity.
Science of Exercise
Exercise has a lot of beneficial effects on our body. However, the mechanism exerting the systemic effects is still unclear. We have challenged to unveil the mechanism underlying the beneficial effect of exercise.
Representative achievements
Kaneshige A, et al, Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load
Cell Stem Cell, 29(2):265-280.e6. 2022
Zhang L, et al, Dlk1 regulates quiescence in calcitonin receptor-mutant muscle stem cells.
Stem Cells,39(3):306-317, 2021
Uezumi A, et al, Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.
J Clin Invest., 131(1):e139617.2021
Cheng W, et al, Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Cell Metab., 31(2):301-312.e5. 2020
Zhang L, et al, The CalcR-PKA-Yap1 axis is critical for maintaining quiescence in muscle stem cells
Cell Reports 29(8):2154-2163, 2019
Fukuda S, et al, Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.
eLife 8. pii: e48284, 2019
Noguchi YT, et al, Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.
Development 146(4). pii: dev163618. 2019
Baghdadi MB,et al, Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche
Nature 557:714-718, 2018
Yamaguchi M, et al, Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.
Cell Reports 13(2):302-14, 2015
Ogawa R, et al, Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.
Development, 2015, 142: 51-61
