NMR

Equipment name: Varian INOVA600

This equipment uses pulses of radiation to investigate the behavior of molecules in a sample solution in a strong magnetic field. It is an effective tool for determining the chemical structure of organic compounds and for determining the three-dimensional structure of biological molecules such as proteins and nucleic acids. The School of Pharmaceutical Sciences operates six sets of high-resolution solution NMR equipment, which are used to identify new pharmaceutical compounds and determine their interactions with biological molecules.

Compact MRI for small animals

Equipment name: DS Pharma Biomedical MRmini SA

A MRI (Magnetic Resonance Imaging) system utilizes a magnetic field and radio waves to create an image of structures inside the body. It allows researchers to observe and evaluate pathological changes in small animals such as mice or rats while they are alive.

Box-type fluorescence microscope

Equipment name: Olympus FSX100

The box-type fluorescence microscope allows the fluorescence from cells and tissues to be easily photographed. Particular components of cells or tissues can be labeled with fluorescence, allowing them to be seen. This is effective in learning about the locations and movement of substances within the cells or tissue.

Confocal laser scanning microscope

Equipment name: Leica TCS SP5

This is a microscope that scans using laser beams in a system known as "confocal". By its ability to acquire in-focus fluorescent images from selected depths, it is possible to observe cross-sections of cells and tissues. This makes it possible to perform high-resolution analysis of the locations and movements of substances inside cells or tissues.

Flow cytometer

Equipment name: Becton, Dickinson and Company FACSAria II cell sorter

This equipment shines laser light onto cells flowing at high speed which have been labeled with a fluorescent substance, and measures the cell population and the strength of fluorescence, allowing the target cells to be collected while alive. It is capable of processing the fluorescence information for several tens of thousands of cells every second, and can collect only the necessary cells among them for cultivation or analysis. This is a powerful tool for understanding cell and molecule functions, and also the effects of drugs.

X-ray diffractometer

Equipment name: Rigaku R-Axis IV++

This equipment irradiates crystals of proteins or organic compounds with X rays in order to photograph the diffraction image. It is able to determine three-dimensional structures of molecules on the atomic coordinate level. This equipment is also necessary in order to identify the stereoisomeric forms that are important in the effects of pharmaceuticals. The School of Pharmaceutical Sciences uses three X-ray diffractometers to determine the three-dimensional structures of organic compounds and proteins.

Computer-aided pharmaceutical design systems

These systems display the three-dimensional structure of proteins or pharmaceutical compounds by means of computer graphics, and are useful in identifying the mechanisms by which proteins operate and in the design of new pharmaceuticals which interact with proteins. The School of Pharmaceutical Sciences is also constructing a new pharmaceutical design system which incorporates parameters related to the interaction of proteins and pharmaceuticals.

ICP-MS

Equipment name: Agilent 7700x ICP-MS (Agilent Technologies)

Using inductively-coupled plasma (ICP) as the ion source, this elemental analysis equipment detects generated ions by means of a mass spectrometer (MS). It is a highly-sensitive analysis device which is capable of detecting heavy metals and other trace element in soil or living organisms at the ppt level (1 part per 1 billion to 1 trillion).

LC-MS

Equipment name: Acquity UPLC (Waters LC), Qattro Premier XE (MS)

By separating various components in a sample by means of a LC, and then measuring the mass with an MS, this equipment is able to identify and quantify the compounds contained in a sample. It is a powerful tool for measuring the concentrations of medicinal components in blood or urine after a drug is administered, and for analyzing the structure of metabolic substances that are generated when the medicinal components are transformed inside the body.

Buildings
Category Structure Constructed in Area (square meter)
Building area Total floor area
Main building R-5 Oct. 1974 1,976 9,567
Annex R-1 Oct. 1974 880 880
Hazardous chemical storageR-1 Oct. 1974 88 88
Canteen R-1 Oct. 1974 216 216
2nd building R-5 Feb. 1997 814 3,484
Medicinal plant garden
(10,610 square meters):
Arbor area and plant area
Administrative building R-2 Aug. 1981 280 560
Large greenhouse S-1 Mar. 1978 310 310
Small greenhouse S-1 Mar. 1978 90 90
Graduate School and School of Pharmaceutical Sciences, Osaka University
1-6 Yamadaoka, Suita, Osaka 565-0871, Japan FAX:+81-6-6879-8154
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