Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H. Development 2011 Nov 138 (21); 4609-19
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult skeletal muscle. This state is considered to be essential for the maintenance of satellite cells, but their molecular regulation is unknown.
Fukada and co-wokers revealed that Hesr1 and Hesr3, known as the Notch effector genes, are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell pool. They also indicated the age-dependent regeneration defect in Hesr1 and Hesr3 double deficient mice. These results might contribute to the identification of molecular target of Sarcopenia.